A Facile Synthesis of Two Brucine-Steroid Derivatives

Abstract

There are studies which show that several derivatives of brucine have been developed for its use in different biological and analytical methods 1-4. For example, a report shows the synthesis of N-chloromethylbrucine chloride by the reaction of brucine with dichloromethane 5. Other studies have shown the preparation of a brucine derivative (brucidine) by electrolytic reduction of brucine 6. In addition, there are reports of the synthesis of N-(5-carboxypentyl)brucinium bromide via N-alkylation of brucine with 6-bromohexanoic acid 7. Other experimental data showed the preparation of compounds brucinium hydrogen (S)-malate pentahydrate and anhydrous brucinium hydrogen (2R,3R)-tartrate by the reaction between brucine and D-L-malic acid or L-tartaric acid in ethanol:water 8. Additionally, the porphyrin-brucine conjugates was synthetized by the N-alkylation of brucine with alkylbromotetraphenylporphyrin derivatives 9. Recently, a brucine derivative (N 1-(2,3-dimethoxy strychnidin-10-yliden)-ethane-1,2-diamine) was synthetized by the reaction of brucine and ethylenediamine using boric acid as catalyst. Also other brucine derivative (11-[(2-aminoethylamino)-methyl]-2,3-dimethoxystrychnidin-10-ona) was prepared by the reaction of brucine with ethylenediamine in presence of formaldehyde 10. Additionally, other study showed the synthesis of a brucine-dihydropirymidine derivative using the multi-component system (brucine, benzaldehyde and

Design and Synthesis of Two Indol-Steroid Derivatives

“…The compounds N 1 -(2,3-dimethoxystrychnidin-10-yliden)ethane-1,2diamine (4) was prepared according to previously reported methods 12 . The other compounds evaluated in this study were purchased from Sigma-Aldrich Co. Ltd.…”

Design and Synthesis of Two Brucine Derivatives

“…The compounds N 1 -(2,3-dimethoxystrychnidin-10yliden)-ethane-1,2-diamine (1) and1-[(2-amino-ethylamino)phenyl-methyl]-naphthalen-2-ol (6) was prepared according to previously reported methods 10,12 . The other compounds evaluated in this study were purchased from Sigma-Aldrich Co. Ltd.…”

“…LAURO FIGUEROA-VALVERDE 1,* , FRANCISCO DÍAZ-CEDILLO 2 , ELODIA GARCÍA-CERVERA 1 , EDUARDO POOL-GÓMEZ 1 , ABELARDO CAMACHO-LUIS 3 , MARCELA ROSAS-NEXTICAPAN 4 , MARÍA LÓPEZ-RAMOS 1 , IVAN MAY-GIL 1 , ANA SARAO-ALVAREZ 1 and CAROLINA NAAL-DZIB 1 thesis of a brucine-dihydropyrimidine derivative using the multi-component system (brucine, benzaldehyde and thiourea) 11 . All these experimental data show several procedures for synthesis of brucine derivatives.…”

“…Additionally, the porphyrin-brucine conjugate was synthetized by the N-alkylation of brucine with alkylbromo tetraphenyl porphyrin derivatives 9 . Recently, a brucine derivative (N 1 -(2,3-dimethoxy strychnidin-10-yliden)-ethane-1,2-diamine) was synthetized by the reaction of brucine and ethylenediamine using boric acid as catalyst 10 . Additionally, other study showed the syn-…”

Design and Synthesis of Three Naphthol Derivatives Using Several Strategies

“…26, No. 18 (2014), [6001][6002][6003][6004] phenanthren-3-ol), 5 (1-[[(2-aminoethyl)amino]-(phenyl) methyl]-2-naphthol) and (4-allyl-2-methoxyphenyl 4-[(2aminoethyl)amino]-4-oxobutanoate) were prepared according to a reported method 10,11 . The other compounds used in this study were purchased from Sigma-Aldrich Co., Ltd.…”