A facile synthesis of 3D NiFe2O4 nanospheres anchored on a novel ionic liquid modified reduced graphene oxide for electrochemical sensing of ledipasvir: Application to human pharmacokinetic study

El-Wekil, Mohamed M.; Mahmoud, Ashraf M.; Alkahtani, Saad A.; Marzouk, Adel A.; Ali, Ramadan

doi:10.1016/j.bios.2018.03.015

Cited by 71 publications

(22 citation statements)

References 31 publications

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“…The previous electrochemical work for determination of LDP reported a linear range: 4.49×10 −7 –3.54×10 −4 M and LOD equals 1.34×10 −7 M . Comparing the linear range and detection limits obtained in this study with previously reported work, the developed sensor has wider linear range with lower detection limit, along with ease of sensor preparation as well.…”

Section: Resultssupporting

confidence: 74%

Graphite/Nanocrystalline Zeolite Platform for Selective Electrochemical Determination of Hepatitis C Inhibitor Ledipasvir

et al. 2018

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A simple and efficient procedure is described for the electrochemical determination of ledipasvir (LDP) in presence of co‐formulated drug sofosbuvir (SOF). Herein, a highly sensitive, low‐cost electrochemical protocol was utilized to fabricate a zeolite modified carbon paste electrode (ZY/CPE) through mixing of zeolite nanostructures with graphite powder. The fabricated sensor displayed high sensitivity, allowing optimal charge transfer/electrode kinetics. Different experimental and chemical factors, including electrode composition, effect of pH, scan rate and amount of ZY were evaluated carefully to obtain the highest electrochemical response. Under optimized conditions and using square wave voltammetry (SWV), the current response of the ZY/CPE electrochemical sensing platform exhibited a detection limit of 7.5×10−9 M and a large linear range from 5.0×10−8 to 1.0×10−4 M. The practical applicability of the suggested electrochemical platform was verified in the assessment of LDP in pharmaceutical formulations with excellent recoveries in the range of 99.50–98.87 %. Moreover, a biological relevance of the developed sensor was established by the analysis of LDP in human urine and plasma samples with satisfactory recoveries of 99.00 and 99.68 %, respectively. Due to the simplicity and ease of preparation of the proposed sensor, it can be used in quality control laboratories and for clinical analysis.

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Section: Resultssupporting

confidence: 74%

Graphite/Nanocrystalline Zeolite Platform for Selective Electrochemical Determination of Hepatitis C Inhibitor Ledipasvir

et al. 2018

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“…The diffraction peak at 11.6° corresponds to (0 1 1) plane of the graphene layer spacing d = 0.776 nm [48] . The diffraction peak in ZnS NPs@rGO at 24.6° corresponds to (0 0 2) plane of rGO [49] , [50] , [51] . The diffraction peaks at 28.6°, 33.8°, 48.2°, 56.8°, 59.8°, 69.3° and 76.4° correspond to the (1 1 1), (2 0 0), (2 2 0), (3 1 1), (2 2 2), (4 0 0) and (3 3 1) crystalline planes of ZnS, which agree well with JCPDS number 05-0566 [52] , [53] .…”

Section: Resultsmentioning

confidence: 99%

Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine

Alkahtani

Mahmoud

Mahnashi

et al. 2021

Microchemical Journal

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“…Moreover, electrochemical impedance spectroscopy (EIS) was used to investigate the surface properties of the modified sensor [45]. The semicircle part in Nyquist plots equals to the electron transfer resistance (Rct).…”

Section: Electrochemical Characterization Of 3d N S@gna 3d N S@gna/ Ccnts and Vs 2 Qds/3d N S@ Gna/ccntsmentioning

confidence: 99%

Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

Mahmoud

Alkahtani

El-Wekil

2021

Microchemical Journal

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A facile synthesis of 3D NiFe2O4 nanospheres anchored on a novel ionic liquid modified reduced graphene oxide for electrochemical sensing of ledipasvir: Application to human pharmacokinetic study

Cited by 71 publications

References 31 publications

Graphite/Nanocrystalline Zeolite Platform for Selective Electrochemical Determination of Hepatitis C Inhibitor Ledipasvir

Graphite/Nanocrystalline Zeolite Platform for Selective Electrochemical Determination of Hepatitis C Inhibitor Ledipasvir

Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine

Simultaneous electrochemical detection of azithromycin and hydroxychloroquine based on VS2 QDs embedded N, S @graphene aerogel/cCNTs 3D nanostructure

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