A Facile Synthesis of 2-Benzoyl-6-Hydroxy-3-Methyl-5-(2-Substituted-2,3-Dihydro-1H-1,5-Benzodiazepin-4-YL) Benzo[b]Furans

Ionic Liquids: A Class of Versatile Green Reaction Media for the Syntheses of Nitrogen Heterocycles

“…In addition, benzodiazepine derivatives are also used in industry as dyes for acrylic fibers in photography. Moreover, they are key intermediates for the preparation of other fused ring compounds such as triazolo [231], oxazino [232], oxadiazolo [233], and furanobenzodiazepines [234].…”

Silica supported fluoroboric acid as a novel, efficient and reusable catalyst for the synthesis of 1,5-benzodiazepines under solvent-free conditions

“…The reaction was very slow with low yield in the absence of catalyst (Table 1, entry 1), while the reaction was very slow giving poor yields of the product with silica as a catalyst at 25 • C ( [6][7][8][9][10][11] and it was observed that the use of just 2 mol% is sufficient to produce an excellent yield of the product (Table 1, entry 9) where as more than 2 mol% of the catalyst did not improve the results (Table 1, entries 10-11). Inferior results were obtained in the presence of solvents (Table 1, entries [12][13][14][15].…”

“…Although benzodiazepines were introduced very earlier, research in this area is still very active and is directed towards the synthesis of compounds with enhanced pharmacological activity. In addition, 1,5 benzodiazepines are valuable synthons used for the preparation of other fused ring compounds such as triazolo [5], oxadiazolo [6], oxazino [7] or furano-benzodiazepines [8]. Benzodiazepine derivatives also found commercial use as dyes for acrylic fibers in photography [9].…”

Sodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives

“…The benzodiazepine derivatives have been found to have wide applications in medical chemistry, such as anticonvulsant, anti-anxiety, analgesic, hypnotic, sedative, antidepressant and anti-inflammatory agents (Smalley, 1979;Landquist, 1984;Randall and Kappel, 1973). In addition, 1,5-benzodiazepines are intermediates used for the synthesis of other fused ring compounds such as triazolo-, oxazino-or furanobenzodiazepines (Essaber et al, 1998;El-snyed et al, 1999;Xu et al, 1999;Zhang et al, 1999;Reddy et al, 2000). On the other hand, quinoxaline derivatives have also shown a broad spectrum of biological activities, which has led them to be privileged structures in drug discovery (Zaragoza and Stephensen, 1999;Wu and Ede, 2001).…”