A facile synthesis, anti-inflammatory and analgesic activity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3′-indoline]-2′,4,9-triones

Straightforward and Highly Diastereoselective Synthesis of a New Set of Functionalized Dispiropyrrolidines Involving Multicomponent 1,3‐Dipolar Cycloaddition with Azomethine Ylides

“…Nitrogen‐containing heterocycles and carbocycles are important structural motifs due to their frequent presence in many biologically active natural products and pharmaceutically relevant molecules . In particular, multifunctional polycyclic spiropyrrolidine represents a privileged heterocyclic skeleton that exists in a large family of naturally occurring alkaloids and synthetic products exhibiting a plethora of biological activities such as antimicrobial , antimycobacterial , anticancer , local anesthetic , anti‐inflammatory, analgesic , and acetylcholinesterase (AChE) inhibition activities . On the other hand, indanone subunits are important core structures of numerous natural and synthetic products endowed with diverse bioactivities .…”

Design of novel dispirooxindolopyrrolidine and dispirooxindolopyrrolothiazole derivatives as potential antitubercular agents

“…Notably spirooxindole and its derivatives have attracted considerable attention due to their highly pronounced biological activities such as antimicrobial, 8 antidiabetic, 9 antiproliferative 10 and anti-inflammatory behaviour. 11 Among those spirooxindoles-derived compounds, spirooxindolopyrrolidines and spirooxindolopyrrolothiazoles are recognized for their antimycobacterial properties and some of them have shown comparable or even better activities than some of the currently employed first-line TB drugs ( Figure 1). 12 In our previous research work, we showed that some spirooxindolepyrrolidine and dispiropyrrolothiazole derivatives incorporating the pyrrolidine-2,5-dione structure possess antibacterial, antifungal, antimalarial and antimycobacterial activities.…”

Synthesis, characterization and evaluation of antidiabetic activity of novel indoline derivatives

“…Indoline based nucleus has been reported to consist of various biological properties such as antimicrobial (Adel et al, 2000;Olgena and Ozkan, 2009;AbdelRahman et al, 2004;Sing and Luntha, 2009), anti-cancer (Sovic et al, 2014;Pengzhan et al, 2014;Xu et al, 2015;Jin et al, 2013), antidiabetic (Sato et al, 2014), antiinflammatory (Fur-man et al, 2014Rajanarendar et al, 2013), antitubulin (Chang et al, 2006). But indoline based target com-pounds have been poorly investigated their antidiabetic activity (Sato et al, 2014).…”