<p class="Abstract">Six compounds of benzothiazole derivatives were synthesized, and structures were confirmed by FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and LC-MS. The resulting compounds were evaluated for anti-plasmodial activity against <em>Plasmodium falciparum</em> by Giemsa stain. Among them the compounds 3b and 4 showed potent anti-plasmodial activity against <em>P. falciparum</em>. The com-pounds 3a, 5a, 5b also showed moderate anti-plasmodial activity. The structure-activity relationships of benzothiazole derivatives also discussed which were useful for exploring and developing benzothiazole derivatives as novel anti-malarial drugs.</p><p> </p>
<p class="Abstract">Series of indoline derivatives were synthesized using N-(4-aminophenyl)indoline-1-carbothiamide as a precursor. The confirmation of synthesized compounds was done by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, LC-MS (ESI) and FT-IR. In vitro antidiabetic activity of synthesized indoline derivatives were examined by standard α-amylase inhibition assay. The compounds 4a (IC<sub>50 </sub>= 52.1 µg/mL) and 4b (IC<sub>50 </sub>= 57.7 µg/mL) showed potent α-amylase inhibition activity. The compounds 3a (IC<sub>50 </sub>= 62.2 µg/mL) and 3b (IC<sub>50 </sub>= 60.7 µg/mL) showed moderate antidiabetic activity.</p><p class="Abstract"><strong>Video Clip of Methodology</strong>:</p><p class="Abstract">19 min 21 sec <a href="https://www.youtube.com/v/k5WdfpM-E8U">Full Screen</a> <a href="https://www.youtube.com/watch?v=k5WdfpM-E8U">Alternate</a></p>
ABSTRACT:The inhibition effect of Parthenium hystophrous L extract on the corrosion of mild steel in 1N sulphuric acid has been studied at different concentrations as well as different temperatures of inhibitor by mass loss studies, adsorption isotherms, Tafel polarization and electrochemical impedance spectroscopy (EIS) between 308 and 338K. The exposed mild steel surface in the presence of inhibitor using Scanning Electron Microscope (SEM) is also studied. The corrosion rate increased with increase in temperature and decrease with increase in concentration of inhibitor compared to blank. The adsorption of this extracts has been found to obey Tempkin and Langmuir adsorption isotherm. Polarization results reveal that the extract is a mixed type inhibitor. The maximum inhibition efficiency of this extract observed at room temperature is 95.12%. @ JASEM
To investigate the phytochemical screening, antibacterial, antifungal and antioxidant activity of the consecutive extract of Murraya Koenigii Roots (called as MKR). This research work comprises four different crude extract and it is mainly focused on the extract of MKRS2.The phytochemical screening for all the crude extract was carried out by the standard method. The antimicrobial activities of MKRS2 extract were evaluated by disk diffusion method. The antioxidant activity of MKRS2 was the determination of DPPH, FRAP and ABTS at different doses and MKRS2 was characterization by TLC, FT-IR and LC-MS. The antimicrobial activity of MKRS2 showed promising effective activities against all the bacterial and fungal pathogens with a maximum zone of inhibition against E.coli 20±1.5 mm and Fusarium rhizopus 20±1.8 mm. The MIC values of antibacterial were shown the maximum range at 150µg / mL and 300µg / mL antifungal activity. The antioxidant activity of MKRS2 exhibits the IC50 values ranging from 24.6 ± 0.8, 27.5 ± 2.2 and 37.7 ± 3.0.The phytochemical constituent's alkaloids, tannins, saponin, carbohydrates, glycosides and oils were present in all the crude extracts.The TLC studies showed the presence of four different UV-active fractions. The FT-IR spectrum indicates the presence of possible functional groups O-H, C=C and N-H starching of aromatic conjugates. The LC-MS of the MKRS2 shows m/z 263 and 332 two different peaks with responsible intensity. These finding shows evidence of MKRS2, an excellent antimicrobial and antioxidant activities and have great potential as a source for natural health care products.
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