A facile preparation of targetable pH-sensitive polymeric nanocarriers with encapsulated magnetic nanoparticles for controlled drug release

Yang, Shun; Chen, Dongyun; Li, Najun; Xiao, Mao; Qi, Xiuxiu; Li, Hua; Xu, Qingfeng; Lu, Jianmei

doi:10.1039/c2jm34817a

Cited by 44 publications

(42 citation statements)

References 41 publications

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“…The peaks at ≈1612 cm −1 and 2855-2920 cm −1 reveal the existence of amine groups (PAH, δ (N-H)) and alkyl chain groups (OTMS, (C-H) n ), respectively ( Figure S2b, Supporting Information). [ 21 ] The XPS data confi rmed the existence of amine groups (N1s) in the outer shell even after coating OTMS on the HMSNPs ( Figure S3a, Supporting Information). Moreover, after the OTMS coating, the peak intensity of the C1s increased remarkably compared to that of the HMSNPs before the OTMS coating, indicating that the long alkyl chain of the OTMS was successfully grafted onto the surface of the HMSNPs.…”

Section: Resultsmentioning

confidence: 66%

Inorganic Micelles (Hydrophilic Core@Amphiprotic Shell) for Multiple Applications

Islam

Choi

Kim

et al. 2015

Adv Funct Materials

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Very little attention has been focused on the purifi cation of water-soluble pollutants after oil/water separation. [ 4 ] Thus, there is considerable interest in developing novel and facile methods for the simultaneous separation of oil from water and purifi cation of water-soluble pollutants.The practical application of organic micelle catalysts that utilize hydrophilic/ hydrophobic interfaces has been limited by several disadvantages. For example, the stability of organic micelles depends on many parameters, such as the solvent polarity, critical micelle concentration, and reaction conditions, such as pH, water/oil ratio, and temperature. [ 10,11 ] Due to the narrow range of stability of organic micelles, the synthesis of inorganic micelles that have hydrophilic/hydrophobic interfaces, large surface areas, high porosities, tunable surfaces, and high recyclability has recently attracted some attention. [ 12,13 ] For example, Lin and co-workers reported a simple route to hierarchically assembling micelles and inorganic nanoparticles. [ 14 ] Yang and co-workers prepared functionalized mesoporous silica spheres consisting of a hydrophobic core and a hydrophilic micellar shell. [ 15 ] As a fi rst example, Alivisatos and co-workers recently reported resin templates based on the synthesis of inorganic micelles with a hydrophilic cavity and a hydrophobic surface and its application as a catalyst in the bromination of alcohol. [ 16 ] There is still considerable interest in developing novel methods for the exploration of interior/ exterior-functionalized, superhydrophobic, and nanostructured inorganic micelles. To fulfi ll the requirements of oil/water separation and inorganic micellar catalysis mentioned above, the development of hierarchical nanomaterials that have a hydrophilic interior and superhydrophobic/hydrophilic (amphiprotic) exterior is highly desirable, offering signifi cant potential for multiple applications. To the best of our knowledge, this report is the fi rst example of the synthesis of nanomaterials that have a hydrophilic core and amphiprotic shell for multiple applications, such as amphiprotic catalytic reactions, oil/water separation and pollutant purifi cation, and enzyme immobilization with signifi cant stability and effi cient recyclability.Herein, we present the preparation and multiple applications of superhydrophobic hollow SiO 2 micelles (SHSMs) with hydrophilic cores and amphiprotic (superhydrophobic/hydrophilic) shell structures that act as "all-in-one" smart nanomaterials. Our SHSMs are better than hydrophilic@hydrophobic micelles prepared using previously reported methods for several reasons: (i) the polyallylamine hydrochloride (PAH) chains were extended and survived from the core to the shell even Inorganic Micelles (Hydrophilic Core@Amphiprotic Shell) for Multiple Applications Md. Shahinul Islam , Won San Choi , * Sun Ha Kim , Oc Hee Han , and Ha-Jin Lee * A facile approach for synthesizing superhydrophobic hollow silica micelles (SHSMs) with hydrophilic cores and amphiprotic (supe...

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Section: Resultsmentioning

confidence: 66%

Inorganic Micelles (Hydrophilic Core@Amphiprotic Shell) for Multiple Applications

Islam

Choi

Kim

et al. 2015

Adv Funct Materials

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“…A wide range of drug delivery formulations have been prepared (Amidi et al, 2008), with some structures capable of triggering release in response to discrete thermal transitions (Lu et al, 2013), pH (Poon et al, 2011;Yang et al, 2012), light (Han et al, 2013), magnetic (Hu et al, 2008), and electric field (Ge et al, 2012;Zhu et al, 2010). However, precisely controlled drug release from the thin films under mild conditions is still a challenge.…”

Section: Introductionmentioning

confidence: 98%

Nanostructured biocompatible thermal/electrical stimuli-responsive biopolymer-doped polypyrrole for controlled release of chlorpromazine: Kinetics studies

Shamaeli

Alizadeh

2014

International Journal of Pharmaceutics

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“…The classification of drug delivery nanosystems. Yang et al (2012) Chi-aDDnSs (targeted nanospheres and pretargeted radioimmunotherapy) Paclitaxel Polymers (ABA-type copolymers, PEG) Bushman et al (2013) Chi-aDDnSs Indomethacin Lipids/Gradient block copolymers Pippa et al (2013b) containing copolymers from poly(isoprene-b-ethylene oxide) diblock copolymers as well as the molecular characteristics of the -lactam functionalized block copolymers was recently published (Gardikis et al, 2010a). Because of the great interest in drug delivery, carriers composed of new biomaterials like block co-polymers or new synthetic dendrimers (i.e.…”

Section: Final Characterization F(chi-) or (Hy-)-amcddnssmentioning

confidence: 99%

“…In the recent literature, mixed nanosystems combing biomaterials and inorganic materials have been introduced for biomedical applications (Yang et al, 2012;Zhang et al, 2012;Liu et al, 2013). The external and/or the internal part of the system could be established by using advanced analytical, chromatographic and spectroscopic techniques.…”

Section: Advanced Drug Delivery Nanosystems and A Proposal To Their Cmentioning

confidence: 99%

“…Various delivery systems including liposomes, dendrimers and polymersomes and particulate drug carriers have been designed and developed so far. The delivery of active substances or candidate drugs can be improved by advanced DDS such as previously described, using therapeutic colloidal nanocarriers and/or inorganic materials (Yang et al, 2012;Zhang et al, 2012;Liu et al, 2013), including polymeric nanoparticles, micelles (Torchilin, 2007), polymeric micelles (Torchilin, 2004), nanotubes (Li et al, 2010) and nanorobits (Kostarelos, 2010;Igbal et al, 2012).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

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Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and to improve its pharmacokinetics. Biocompatible nanomaterials have been used as biological markers, contrast agents for imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. The classification of drug delivery nanosystems (DDnSs) is a crucial issue and fundamental efforts on this subject are missing from the literature. This article deals with the classification of DDnSs with a modulatory controlled release profile (MCR) denoted as modulatory controlled release nanosystems (MCRnSs). Conventional (c) and advanced (a) DDnSs are denoted by the acronyms cDDnSs and aDDnSs, and can be composed of a single or more than one biomaterials, respectively. The classification was based on their characteristics such as: surface functionality (f), the nature of biomaterials used and the kind of interactions between biomaterials. The aDDnSs can be classified as hybridic (Hy-) or chimeric (Chi-) based on the nature -same or different respectively -of biomaterials and inorganic materials used. The nature of the elements used for producing advanced biomaterials is of great importance and medicinal chemistry contributes effectively to the production of aDDnSs.

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A facile preparation of targetable pH-sensitive polymeric nanocarriers with encapsulated magnetic nanoparticles for controlled drug release

Cited by 44 publications

References 41 publications

Inorganic Micelles (Hydrophilic Core@Amphiprotic Shell) for Multiple Applications

Inorganic Micelles (Hydrophilic Core@Amphiprotic Shell) for Multiple Applications

Nanostructured biocompatible thermal/electrical stimuli-responsive biopolymer-doped polypyrrole for controlled release of chlorpromazine: Kinetics studies

Advanced drug delivery nanosystems (aDDnSs): a mini-review

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