A facile preparation of 2,6-diarylpyrazines

Abstract

2,6‐Diarylpyrazines were prepared in good yields by a novel method of condensing methoxycarbonylhydrazine with N,N‐bis(arylcarbonylmethyl)‐p‐toluenesulfonamides, unsymmetrical derivatives of which were synthesized by a new (or different) procedure. The structures of these 2,6‐diarylpyrazines were established by spectral data and X‐ray diffraction analysis. © 1998 John Wiley & Sons, Inc. Heteroatom Chem 9:341–345, 1998

Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes

“…Pyrazines are also synthesized using α-halo ketones 16 or by the condensation reaction of diamines and epoxides. 17 Dehydrogenation of piperazines to form pyrazine derivatives was also reported using heterogeneous catalysts.…”

Base‐Catalyzed NN Bond Cleavage of Hydrazones: Synthesis of α‐Amino Ketones

“…Accordingly, considerable attention has been paid to the development of efficient approaches to their synthesis 10. 11 However, secondary α‐sulfonylamino ketones 4 cannot be prepared directly from sulfamide and 2‐bromoacetophenone 12. These types of α‐amino ketones are constructed from the ring‐opening of aziridines10a–d or the oxidation of allylic amines 10e.…”

Palladium(II)-Catalyzed Intramolecular Tandem Cyclization Reaction for the Assembly of Unsymmetrical 2,6-Disubstituted Pyrazines

“…Subsequent cyclization with hydrazine led to the formation of unsymmetrical 2,6-disubstituted pyrazines. 16 Another group developed a microwave strategy to unsymmetrical 2,6-disubstituted pyrazines through an intramolecular hydroamination sequence (Scheme 1B). 17 However, there still remained the issue of…”