A Facile Plant Mediated Synthesis of Magnetite Nanoparticles Using Aqueous Leaf Extract of Ficus Hispida L. for Adsorption of Organic Dye

Ramesh, Abhinav; Lavakusa, B.; Mohan, Balaji; Kumar, Y. Pavan; Devi, Dharmasoth Rama; Basavaiah, K.

doi:10.9790/5736-1007013543

Cited by 9 publications

(1 citation statement)

References 24 publications

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“…Hence, an alternative approach is required to overcome the problem of cancer‐targeted treatment through nano‐medicine is the main research area now a days. Targeted chemotherapy‐based drug delivery is the leading method for the treatment of cancer through nanotechnology which is more effective …”

Section: Introductionmentioning

confidence: 99%

Eco‐friendly synthesis of ZnO nanorods using Cycas pschannae plant extract with excellent photocatalytic, antioxidant, and anticancer nanomedicine for lung cancer treatment

Sudha¹,

Ali²,

Karunakaran

et al. 2020

Applied Organom Chemis

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The tunable ZnO nanorods (NRs) are produced due to the phytochemicals present in Cycas pschannae leaves which act as reducing and stabilizing agents. The confirmations of the ZnO NRs were validated using different characterization techniques: X‐ray diffraction, Fourier transform infrared spectroscopy, Brunauer, Emmett and Teller (BET), scanning electron microscopy–Energy Dispersive X‐Ray Analysis (EDX), UV–visible spectroscopy, Raman spectroscopy, and transmission electron microscopy. The ZnO NRs show unique surface area and low particle size. Photocatalytic activity was measured and found to be 50.75% at low concentrations and 78.33% at high concentrations. The antioxidant activity of the ZnO NRs also showed promising results for their use in free radical scavenging. In vitro toxicity studies using zebrafish embryos was performed to evaluate the toxic nature of it and the obtained result confirmed its non‐toxic nature. In addition, ZnO anticancer potential was verified using the A549 lung cancer cell line. Cytotoxic assessments of ZnO NRs were performed via 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide (XTT), 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT), and neutral red uptake assays to examine the cell death cycle on the A549 lung cancer cell. Dose‐dependent apoptosis and necrosis were confirmed by Lactate dehydrogenase (LDH) assay. It was also confirmed that ZnO NRs induce Reactive oxygen species (ROS) and apoptosis inside cancer (A549) cells via different intrinsic gene expression. Thus, based on this research it is evident that an effective ecofriendly, nontoxic potential anticancer drug can be synthesized using C. pschannae leaf extract.

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Section: Introductionmentioning

confidence: 99%