A Facile One‐Pot Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐1‐carbonitriles via the Electrogenerated Cyanide Anions from Acetonitrile

Abstract

The electrosynthesis of 1,2,3,4-tetrahydroisoquinoline-1-carbonitriles by acetonitrile reduction is a green and safe strategy to replace the traditional cyanation. Herein, we have obtained the 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile in good yields by a simple reaction between dihydroisoquinolin-2-ium iodide and the electrogenerated acetonitrile formed under low temperature conditions, when a solution of dry acetonitrile is electrolyzed at a Carbon rod as cathode and a magnesium plate as anode in undivided cell. ChemistrySelectCommunications

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“…The authors have cited additional references within the Supporting Information (Ref. [41][42][43][44][45][46][47][48][49][50])…”

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