A Facile Microwave Assisted Synthesis and Spectral Analysis of 2-Amino-5-substituted phenyl-1,3,4-Oxadiazoles

Abstract

Synthetic organic chemists explore new methods for chemical transformation. In recent year lot of work has been carried out to use microwave irradiation as an alternative to conventional heating which provide higher yield and cleaner product. ABSTRACTAn efficient synthesis for the preparation of some 2-amino-5-substituted phenyl-1,3,4-oxadiazoles by using both conventional and microwave method have been devised. The obtained results revealed that, microwave assisted technique is efficient, eco-friendly and inexpensive method which not only give higher yield but also reduces the reaction time significantly. The resulting compounds were characterized by IR, 1 H-NMR, UV-Vis and mass spectral analysis.

A Facile Microwave Assisted Synthesis and Spectral Analysis of 2 Furyl 5 Substituted 1,3,4 Oxadiazoles

“…It was neutralized with sodium bicarbonate solution and the resulting solid was filtered, dried and re crystallized from methanol. [16][17][18] Microwave method Preparation of furan-2-carboxylic acid ethyl ester In a double necked flask, a mixture of 11.2 g furoic acid and 60 ml ethanol were refluxed by microwave irradiation at 360W for 12 minutes. The reaction is catalyzed using 1 ml HCl.…”