A Facile and Efficient Synthesis of 2‐(5‐(4‐Substitutedphenyl)‐4, 5‐dihydro‐3‐phenylpyrazol‐1‐yl)‐6‐Substitutedbenzothiazoles and Their Biological Studies

Abstract

A series of new 1‐substituted 3, 5‐diarylpyrazolines (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25) were synthesized in good yield by both conventional and microwave‐assisted synthesis from α, β‐ unsaturated ketones (6, 7, 8, 9) in n‐butanol and benzothiazole hydrazines (2, 3, 4, 5). All the new compounds were characterized by IR, NMR, and mass spectral data. The synthesized compounds (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25) were evaluated for antibacterial and anthelmintic activities. The compounds showed potent anthelmintic activity against earthworm species (Eudrilus eugeniae) and moderate antibacterial activity against bacterial strains such as Gram positive bacteria, Enterococcus faecalis, Staphylococcus aureus, and Bacillus subtilis, and Gram negative bacteria, Escherichia coli and Proteus mirabilis.

Improving surface structure of photocatalytic self‐cleaning membrane by WO3/PANI nanoparticles

“…The absorption bands at 2851 cm −1 and 2919 cm −1 are corresponded to asymmetrical and symmetrical C―H stretching vibrations. The strong peak at 3432 cm −1 can be assigned to both N―H stretching and O―H stretching bands.…”

In silico ADME predictions and in vitro antibacterial evaluation of 2-hydroxy benzothiazole-based 1,3,4-oxadiazole derivatives

“…In recent years, heterocyclic compounds have emerged as a potent scaffold in medicinal chemistry, as they influence the properties of a drug in terms of lipophilicity, solubility, and so on [3]. Benzothiazole is an important heterocyclic pharmacophore with various pharmacological properties, such as antimicrobial [4][5][6], anticancer [7], antidiabetic [8], antiviral [9], antimalarial [10], antihelimintic [11], anticonvulsant [12,13], and antileishmanial [14] properties. This moiety is present in many marketed drugs like ethoxzolamide, frentizole, riluzole etc.…”

Synthesis of novel bis- and poly(hydrazinylthiazole) linked to benzofuran or benzothiazole as new hybrid molecules

“…34 Several clinically approved drugs based on benzofuran moiety are outlined in Figure 1. [35][36][37][38] Furthermore, benzothiazole core is an important scaffold for drug development, because it has demonstrated a wide spectrum of pharmacological activities and therapeutic functions including antitumor, 39,40 antimicrobial, 41,42 anti-tubercular, 43,44 anti-HIV, 45 anti-malarial, 46 anti-convulsant, 47 anthelmintic, 48,49 anti-oxidant 50 and analgesic. Synthesis and biological activities of benzothiazoles have been recently reviewed.…”