A dynamic biomechanical analysis of the etiology of adolescent tibia vara

Davids, Jon R.; Bagley, Anita; Huskamp, Michelle

doi:10.1016/0966-6362(95)93497-z

Cited by 8 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there remains a need for longitudinal studies of the relationship between fat and bone from childhood to adulthood to determine whether there are key stages during which excessive fat limits bone mass accrual. The detrimental effect of excessive mechanical loading on bone from excess fat mass in children has been based on the increased risk of slipped capital femoral epiphysis (67) and tibia vary in obese children (68). But, major concerns that excess fat mass may have a detrimental effect on bone mass acquisition in children originated from observations that obese children were overrepresented in fracture groups in studies that sought to evaluate the prevalence of fractures in children (69)(70)(71).…”

Section: Bone and Energy Metabolismmentioning

confidence: 99%

Bone Remodeling and Energy Metabolism: New Perspectives

Paula

Rosen

2013

Bone Res.

View full text Add to dashboard Cite

Bone mineral, adipose tissue and energy metabolism are interconnected by a complex and multilevel series of networks. Calcium and phosphorus are utilized for insulin secretion and synthesis of high energy compounds. Adipose tissue store lipids and cholecalciferol, which, in turn, can influence calcium balance and energy expenditure. Hormones long-thought to solely modulate energy and mineral homeostasis may influence adipocytic function. Osteoblasts are a target of insulin action in bone. Moreover, endocrine mediators, such as osteocalcin, are synthesized in the skeleton but regulate carbohydrate disposal and insulin secretion. Finally, osteoblasts and adipocytes originate from the same mesenchymal progenitor. The mutual crosstalk between osteoblasts and adipocytes within the bone marrow microenvironment plays a crucial role in bone remodeling. In the present review we provide an overview of the reciprocal control between bone and energy metabolism and its clinical implications.

show abstract

Section: Bone and Energy Metabolismmentioning

confidence: 99%

Bone Remodeling and Energy Metabolism: New Perspectives

Paula

Rosen

2013

Bone Res.

View full text Add to dashboard Cite

show abstract

“…In spite of this, our fracture cases had lower bone mass and bone area density throughout their skeletons than fracture-free controls, and we suggested that a low bone mineral content relative to body weight might make overweight children vulnerable to fragility fractures. 7,8 Others report low bone density in the spine and radius of overweight children 9 ± 11 and orthopaedic problems such as slipped capital epiphyses of the femora, 12 scoliosis and tibia varu 13 are recognized health risks of childhood obesity.…”

Section: Introductionmentioning

confidence: 99%

Overweight and obese children have low bone mass and area for their weight

et al. 2000

View full text Add to dashboard Cite

OBJECTIVES: To determine whether girls and boys categorized from body mass index (BMI) values as overweight or obese for their age have lower bone mineral content (BMC) or lower bone area in relation to total body weight than children of normal adiposity. DESIGN: Cross-sectional study in a university bone research unit. SUBJECTS: Two hundred girls and 136 boys aged 3 ± 19 y recruited from the general population by advertisement. MEASUREMENTS: Total body BMC (g) and bone area (cm 2 ) measured by dual energy X-ray absorptiometry (DXA) in relation to body weight (kg), lean tissue mass (kg) and fat mass (kg) in boys and girls of three different BMI percentile groupings: normal weight (BMI`85th percentile); overweight (85 to 94th BMI percentile); obese ( 95th BMI percentile). RESULTS: Obese children had higher BMC, bone area, and fat mass for chronological age than those of normal body weight (P`0.001). In spite of this the observed values for age-adjusted total body BMC and bone area relative to body weight were each lower than predicted values, in both overweight and obese children (2.5 ± 10.1% less, P`0.05) than in children of lower adiposity. CONCLUSION: In overweight and obese boys and girls there is a mismatch between body weight and bone development during growth: their bone mass and bone area are low for their body weight.

show abstract

“…Obese individuals with large thighs have a very difficult time adducting the hip adequately to place the foot for midline progression. Davids et al 22 speculated that this "fat thigh syndrome" produces a varus moment on the knee that leads to increased pressure on the medial aspect of the proximal tibial physis and inhibits growth in accordance with the Hueter-Volkmann law 23 . Since 1994, we have addressed all of the deformities associated with late-onset tibia vara with a comprehensive approach.…”

mentioning

confidence: 99%

“…Although late-onset tibia vara occasionally may occur in thin or normal-sized patients, the majority of patients are obese 2,6,[16][17][18][19][20][21] . These patients typically are in the ninetieth percentile of weight for both age and height 17,18,[20][21][22] . During normal walking, nonobese individuals place the foot close to the midline of foot progression, thereby minimizing weight transfer and energy expenditure.…”

mentioning

confidence: 99%