A dual thermoresponsive and antifouling zwitterionic microgel with pH triggered fluorescent “on-off” core

Banerjee, Shib Shankar; Saha, Pabitra; Ganguly, Ritabrata; Bhattacharya, Koushik; Kalita, Uddhab; Pich, Andrij; Singha, Nikhil K.

doi:10.1016/j.jcis.2020.12.018

Cited by 21 publications

(11 citation statements)

References 100 publications

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“…Along with that, the presence of Rhodamine B-type fluorescence dye inside the microgel makes the system also equally important to trace the cancer cells for targeted drug delivery under an acidic environment. [169] The anti-fouling behavior of zwitterionic microgels has proved to be useful to enhance the sensitivity and detection limits of different antibiotics as well such as streptomycin (STR). He and coworkers synthesized microgels involving the zwitterionic component of Poly(1-propyl-3-vinylimidazole sulfonate) (PVIS) which in conjunction with comonomers like N-isopropylacrylamide (NIPAM) and acrylic acid (AA) show excellent protein-repellent behavior in complex media like uncured milk, thereby improving the sensitivity and detection limit of the particular antibiotic.…”

Section: Anti-fouling Coatingsmentioning

confidence: 99%

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Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications

Saha

Ganguly

et al. 2021

Macromol. Rapid Commun.

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Zwitterionic polymers by virtue of their unique chemical and physical attributes have attracted researchers in recent years. The simultaneous presence of positive and negative charges in the same repeat unit renders them of various interesting properties such as superhydrophilicity, which has significantly broadened their scope for being used in different applications. Among polyzwitterions of different architectures, micro-and/or nano-gels have started receiving attention only until recently. These 3D cross-linked colloidal structures show peculiar characteristics in context to their solution properties, which are attributable either to the comonomers present or the presence of different electrolytes and biological specimens. In this review, a concise yet detailed account is provided of the different synthetic techniques and application domains of zwitterion-based micro-and/or nanogels that have been explored in recent years. Here, the focus is kept solely on the "polybetaines," which have garnered maximum research interest and remain the extensively studied polyzwitterions in literature. While their vast application potential in the biomedical sector is being detailed here, some other areas of scope such as using them as microreactors for the synthesis of metal nanoparticles or making smart membranes for water-treatment are discussed in this minireview as well.

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Section: Anti-fouling Coatingsmentioning

confidence: 99%

“…Along with that, the presence of Rhodamine B‐type fluorescence dye inside the microgel makes the system also equally important to trace the cancer cells for targeted drug delivery under an acidic environment. [ 169 ]…”

Section: Applications Of Zwitterionic Nanogels and Microgelsmentioning

confidence: 99%

Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications

Saha

Ganguly

et al. 2021

Macromol. Rapid Commun.

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“…Besides, their antifouling and antifreezing properties are well documented as well. [17][18][19][20][21][22] They also show greater stability toward alkaline hydrolysis in basic medium unlike poly(ethylene glycol) (PEG)-based polymers. [23,24] To the best of our knowledge, there is no report on functional block copolymers (BCPs) bearing hydrophilic zwitterionic block along with dopamine containing thermoresponsive block and on their interactions with metal ions in aqueous environment.…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐Responsive Block Copolymer Micelles Based on Mussel‐Inspired Metal‐Coordinated Supramolecular Networks

Ganguly

Saha

Banerjee

et al. 2021

Macromol. Rapid Commun.

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Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe 3+ ) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles cross-linked via metal-catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.

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“…Stimuli-responsive copolymers that can respond to external stimuli or changes in the surrounding environment, , for example, pH, , temperature, , light, − magnetism, and other types, to make adaptable changes have aroused considerable interest . Copolymers containing pH-responsive ionizable groups, such as carboxylic acids and amines, have been extensively investigated.…”

mentioning

confidence: 99%

“…Among them, fluorescent copolymers have attracted significant attention due to their high stability, signal amplification, designable structure, and high water solubility. 13 Stimuli-responsive copolymers that can respond to external stimuli or changes in the surrounding environment, 14,15 for example, pH, 16,17 temperature, 18,19 light, 20−22 magnetism, 23 and other types, to make adaptable changes have aroused considerable interest. 24 Copolymers containing pH-responsive ionizable groups, 25 such as carboxylic acids and amines, have been extensively investigated.…”

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confidence: 99%

Amphiphilic Asymmetric Diblock Copolymer with pH-Responsive Fluorescent Properties

Zhang

Harrisson

2021

ACS Macro Lett.

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Stimuli-responsive polymers with changeable fluorescent properties have numerous applications in sensing, bioimaging, and detection. Here we describe the facile synthesis of a pH-responsive amphiphilic asymmetric diblock copolymer of acrylic acid and butyl acrylate that incorporates a polarity-sensitive fluorophore. The asymmetric structure enhances the stimuliresponsive behavior: as the environmental pH decreases, the fluorescent intensity of the asymmetric diblock copolymer gradually increases, whereas its symmetric block counterpart shows limited and stepwise change. Besides, this remarkable difference was demonstrated to be concentration-independent, as similar emission behavior was found for both polymers at lower concentrations. These results indicate that the fluorescence properties of the copolymer can be adjusted by rationally designing the copolymer structure. This work provides a novel and general strategy for the design and synthesis of polymeric materials with encapsulated structures showing stimuli-responsive fluorescent properties to be applied as fluorescent probes with a smoothly varying response curve rather than the simple on−off switch that is typical of block copolymer systems.

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A dual thermoresponsive and antifouling zwitterionic microgel with pH triggered fluorescent “on-off” core

Cited by 21 publications

References 100 publications

Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications

Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications

Stimuli‐Responsive Block Copolymer Micelles Based on Mussel‐Inspired Metal‐Coordinated Supramolecular Networks

Amphiphilic Asymmetric Diblock Copolymer with pH-Responsive Fluorescent Properties

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