Stimuli‐Responsive Block Copolymer Micelles Based on Mussel‐Inspired Metal‐Coordinated Supramolecular Networks

Ganguly, Ritabrata; Saha, Pabitra; Banerjee, Shib Shankar; Pich, Andrij; Singha, Nikhil K.

doi:10.1002/marc.202100312

Cited by 7 publications

(5 citation statements)

References 40 publications

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“…Ganguly et al also designed a cross-linked micelle based on pH-responsive chemistry, but utilized ironcatechol supramolecular coordination bonds that were acid labile, as opposed to acid cleavable linkers. 445 This design also employed a tri-block copolymer composed of polydopamine, PNIPAm, and a zwitterionic polymer component to form micelles that underwent morphological changes at pH levels relevant to the endosome. Temperature-responsive crosslinked micelles were designed by Chen et al, who utilized the thermoresponsive behavior of PNIPAm (Figure 37B).…”

Section: Micellesmentioning

confidence: 99%

“…The pH and reducing environment of the endosome resulted in micelle disassembly and the rapid release of DOX. Ganguly et al also designed a cross-linked micelle based on pH-responsive chemistry, but utilized iron-catechol supramolecular coordination bonds that were acid labile, as opposed to acid cleavable linkers . This design also employed a tri-block copolymer composed of polydopamine, PNIPAm, and a zwitterionic polymer component to form micelles that underwent morphological changes at pH levels relevant to the endosome.…”

Section: Spherical Nanoparticlesmentioning

confidence: 99%

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Polymeric Nanoparticles for Drug Delivery

Beach,

Nayanathara,

Gao

et al. 2024

Chem. Rev.

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The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated the creation of more sophisticated drug delivery systems. Polymeric nanoparticles sit at the forefront of numerous promising drug delivery designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, and surface functionality. Furthermore, polymeric nanoparticles have the ability to navigate various biological barriers to precisely target specific sites within the body, encapsulate a diverse range of therapeutic cargo and efficiently release this cargo in response to internal and external stimuli. However, despite these remarkable advantages, the presence of polymeric nanoparticles in wider clinical application is minimal. This review will provide a comprehensive understanding of polymeric nanoparticles as drug delivery vehicles. The biological barriers affecting drug delivery will be outlined first, followed by a comprehensive description of the various nanoparticle designs and preparation methods, beginning with the polymers on which they are based. The review will meticulously explore the current performance of polymeric nanoparticles against a myriad of diseases including cancer, viral and bacterial infections, before finally evaluating the advantages and crucial challenges that will determine their wider clinical potential in the decades to come.

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Section: Micellesmentioning

confidence: 99%

Section: Spherical Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Drug Delivery

Beach,

Nayanathara,

Gao

et al. 2024

Chem. Rev.

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“…pH/thermo-responsive polymers are the most widely studied dual-responsive polymers [78,[110][111][112]128]. Similar to the individual pH-responsive polymers and temperatureresponsive polymers, these dual-responsive polymers allow for a much more specific and targeted environment to activate the polymer.…”

Section: Ph/temperature-responsive Polymersmentioning

confidence: 99%

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

2022

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Polymers that can change their properties in response to an external or internal stimulus have become an interesting platform for drug delivery systems. Polymeric nanoparticles can be used to decrease the toxicity of drugs, improve the circulation of hydrophobic drugs, and increase a drug’s efficacy. Furthermore, polymers that are sensitive to specific stimuli can be used to achieve controlled release of drugs into specific areas of the body. This review discusses the different stimuli that can be used for controlled drug delivery based on internal and external stimuli. Internal stimuli have been defined as events that evoke changes in different characteristics, inside the body, such as changes in pH, redox potential, and temperature. External stimuli have been defined as the use of an external source such as light and ultrasound to implement such changes. Special attention has been paid to the particular chemical structures that need to be incorporated into polymers to achieve the desired stimuli response. A current trend in this field is the incorporation of several stimuli in a single polymer to achieve higher specificity. Therefore, to access the most recent advances in stimuli-responsive polymers, the focus of this review is to combine several stimuli. The combination of different stimuli is discussed along with the chemical structures that can produce it.

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“…Microgels are garnering a significant interest amongst the scientific community owing to their ability to manifest interesting DOI: 10.1002/macp.202200349 solution properties in aqueous media such as high swellability, ability to respond to different stimuli such as temperature, pH and ionic strength, and so on. [1][2][3][4][5] These properties have been deemed ideal to be explored for their potential applications especially in the biomedical sector. [6,7] Amongst the existing literature available, N-isopropyl acrylamide (NIPAM)-based microgels have been by far the most widely reported, the reason being their ability to transition between phases around the physiological temperature range, which makes them lucrative agents to be used for biological applications.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Microgels with High Loading of Zwitterions Exhibiting Superior Performance: A Macromonomer Approach

Ganguly

Saha

Kringe

et al. 2022

Macro Chemistry & Physics

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In this investigation, the synthesis of temperature-responsive microgels containing high content of zwitterionic poly(phosphorylcholine) (PMPC) is reported. High loadings of polyzwitterionic chains are achieved by using PMPC-based "macromonomers," which are synthesized via a three-step reaction process. The first step involves synthesis of PMPC homopolymers via reversible addition fragmentation transfer (RAFT) polymerization, followed by end-group removal to generate reactive thiol groups, and last of all, introduction of polymerizable double bonds at the chain ends to provide PMPC-based macromonomers. Macromonomers of three different molar masses (3000, 5000, and 10 000 g mol −1 ) are used in three different molar ratios (1, 3, and 5 mol%) to synthesize microgels using N-vinylcaprolactam (NVCL) as the main co-monomer in precipitation polymerization. It is observed that the extent of total incorporation of the zwitterionic moiety is a function of both the macromonomer molar mass as well as its molar fraction in the feed which has a direct effect on their solution properties such as hydrodynamic radii and volume phase transition temperature (VPTT). Interestingly, these microgels show unprecedented extent of protein-repelling behavior owing to higher loading of zwitterionic moieties, what makes them interesting for the fabrication of protective coatings with anti-fouling properties.

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Stimuli‐Responsive Block Copolymer Micelles Based on Mussel‐Inspired Metal‐Coordinated Supramolecular Networks

Cited by 7 publications

References 40 publications

Polymeric Nanoparticles for Drug Delivery

Polymeric Nanoparticles for Drug Delivery

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

Thermoresponsive Microgels with High Loading of Zwitterions Exhibiting Superior Performance: A Macromonomer Approach

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