A dual-targeted nucleic acid moiety decorated SPION nanoparticles for chemo-photodynamic synergistic therapy

Sun, Xueqing; Liu, Minchao; Chen, Xianli; Lin, Hui-Chao; Liu, Bing; Peng, Yi; Zhang, Luyong; Shen, Jianliang; Zhao, Ping

doi:10.1016/j.jlumin.2019.02.019

Cited by 15 publications

(26 citation statements)

References 38 publications

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“…The formation of G-quadruplex structure for AS1411 aptamer was thus confirmed. 33,34,40,41 The presence of porphyrin in the PpIX-Apt-UCNP nanospheres could be further confirmed by the results of solid state UV-Vis spectra (Figure 2(b)). It was found that UCNP has no substantial absorption while the PpIX-Apt-UCNP has the characteristic absorption peak (Soret band around 410 nm) of porphyrin.…”

Section: Synthesis and Characterization Of Ppix-apt-ucnpmentioning

confidence: 55%

“…Meanwhile, our previous research indicates that singlet oxygen ( 1 O 2 ) is the main species produced by porphyrin compounds under irradiation. [32][33][34]47 To further understand the mechanism of the photodynamic cell cytotoxicity of the PpIX-Apt-UCNP nanospheres, we evaluated the 1 O 2 generation by the absorption change of RNO following the Kraljic procedure. 39 PS PpIX in the light irradiation could react with O 2 to produce 1 O 2 and the intermediates of 1 O 2 and could cause RNO oxidation, resulting in the absorbance reduction of RNO at 440 nm.…”

Section: Cell Photocytotoxicity and Singlet Oxygen Generation Of Ppixmentioning

confidence: 99%

“…On the other hand, the quadruplex structures have been previously proved to be able to load porphyrin PS, such as N-methylmesoporphyrin IX (NMM) and 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP). [32][33][34][35][36][37] Since the AS1411 aptamer is an excellent selector for the higher nucleolin-expressing cancer cells and a good candidate for carrying porphyrin ligands because of its quadruplex structure, it has been frequently employed as a tether for the drug nanocarrier.…”

Section: Introductionmentioning

confidence: 99%

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Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

Lin

Madanayake

et al. 2019

J Biomater Appl

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Current photodynamic therapy faces two major challenges, which are the limited tissue penetration of excitation light and poor tumor selectivity of the photosensitizer. To address these issues, in the present work, a photosensitizer protoporphyrin IX was delivered by aptamer-coated upconversion nanoparticles. The aptamer, namely, AS1411, could fold to G-quadruplex structures with the bi-functions of loading protoporphyrin IX and targeting the cancerous cells. The protoporphyrin IX aptamer-coated upconversion nanoparticle nanospheres exhibited good biocompatibility, high nuclease resistance, and targeted cellular internalization. The receptor blocking experiment indicated that the cellular uptake of protoporphyrin IX aptamer-coated upconversion nanoparticle mainly attributed to the binding of AS1411 to the nucleolin overexpressed on the cancerous cell membrane. Moreover, high-efficient photodynamic therapy of the asprepared protoporphyrin IX aptamer-coated upconversion nanoparticle nanospheres was achieved to cancerous cells under the irradiation of near-infrared light, which was induced by the upconversion property of the upconversion nanoparticle. These results indicate that the fabricated protoporphyrin IX aptamer-coated upconversion nanoparticle nanoplatform has higher efficiency, lower toxicity, and less side effects compared to the free photosensitizer protoporphyrin IX, and thus is a new promising photodynamic therapy agent especially for the deep-seated tumors.

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Section: Synthesis and Characterization Of Ppix-apt-ucnpmentioning

confidence: 55%

Section: Cell Photocytotoxicity and Singlet Oxygen Generation Of Ppixmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

Lin

Madanayake

et al. 2019

J Biomater Appl

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“…Their advantages are first that they are very specific, non-immunogenic, and biocompatible. Sun and co-workers reported the conjugation of a hybridized DNA structure with superparamagnetic iron oxide nanoparticles (SPIONs) in order to obtain targeted drug delivery systems [105]. This hybridized DNA structure is composed of an aptamer, an intercalated motif (i-motif), and ds-DNA: the i-motif DNA is a type of deoxyribonucleic acid with a four-stranded quadruplex structure, whereas ds-DNA is the double stranded DNA.…”

Section: Novel Strategy: Hybridized Dna Structurementioning

confidence: 99%

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Pinelli

Perale

Rossi

2020

Gels

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Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be adopted in order to modify the selectivity of the nanoparticles in the delivery process and obtain a final system with great targeted drug delivery ability. We also highlight the most important fields of application of these kinds of delivery systems and we propose a comparison between the advantages and disadvantages of the described functionalization strategies.

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“…The delivery system displayed controlled drug release to cancer microenvironments. 21 Ultrasound is also an excellent external stimulus due to efficient tissue penetration and non-invasiveness. Apart from established clinical ultrasound imaging, ultrasound induces apoptosis in the tumor through thermal effects like hyperthermia or nonthermal effects like cavitation.…”

Section: Introductionmentioning

confidence: 99%

<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

Wang¹,

Wu²,

Shen³

et al. 2020

IJN

129

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Background: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions. Methods: In this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS 2 QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy. Results: This review found much evidence for the use of inorganic nanoparticles for PTTbased combinational cancer therapy. Conclusion: Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.

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A dual-targeted nucleic acid moiety decorated SPION nanoparticles for chemo-photodynamic synergistic therapy

Cited by 15 publications

References 38 publications

Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

Aptamer-guided upconversion nanoplatform for targeted drug delivery and near-infrared light-triggered photodynamic therapy

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

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