A Dual Synergetic Nanoreactor for Managing Parkinson's Disease by Regulating Inflammation and Mitigating Oxidative Damage

Abstract

Glial cell‐dominated inflammatory microenvironment and neuronal damage due to oxidative stress are major impediments to the treatment of central nervous degenerative diseases. Herein, a neuroinflammatory regulatory nanoreactor is developed by encapsulating dihydroquercetin (Que) and Pt nanozymes (Ptzymes) in mannitol modified poly(lactic‐co‐glycolic acid) nanoparticles. The nanoreactor shows enhanced antioxidative activities compared with either Que or Ptzymes alone due to synergetic effects of the incorporated active agents. In cellular and animal models of Parkinson's disease (PD), the nanoreactor traverses the blood–brain barrier and accumulates in neurons and microglia, thereby mitigating oxidative damage of neurons, and promoting the polarization of microglia into the anti‐inflammatory M2‐phenotype to control PD progression. This work demonstrates the gains of combining anti‐inflammation small molecule compound and antioxidant nanozyme in a synergetic nanoreactor to effectively prevent neuronal damage and suppress the inflammatory microenvironment, which holds great potential for managing the advances of PD.

A metal–organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury

“…5,6,9–12 Nanozymes possessing distinctive physical, chemical, and biological properties inherent to nanomaterials along with enzyme-like catalytic activity are a subject of continuous exploration and research. 13–16 Compared with natural enzymes, nanozymes have the advantages of easy preparation, high stability and low cost, which makes nanozymes continue to develop rapidly, and have been widely used in biomedicine, environmental protection, energy supply and other fields. 9,10 After over a decade of extensive development, the repertoire of nanozymes has progressively expanded to encompass key enzymes such as SOD, glutathione peroxidase, CAT, and phosphatases, among others.…”

Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy

“…[1][2][3][4][5][6][7][8][9][10][11] Developing highly effective nanozymes has been as of the key issues in the field of catalytic therapy. [12][13][14][15][16][17][18][19] Since Fe 3 O 4 nanoparticles were first reported to exhibit activity similar to that of natural horseradish peroxidase in 2007, [20] various nanomaterials have been designed and developed as nanozymes, including noble metals (e.g., Pt, Au, and Pd), metal oxides (e.g., MnO 2 , MoO 3 , WO 3 , Co 3 O 4 , Cu 2 O, and CeO 2 ), layered double hydroxides (LDHs), carbon nanomaterials, and transition metal chalcogenides (e.g., MoS 2 , FeS 2 , and MoSe 2 ). [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Among them, metal oxides have received considerable attention as nanozymes for catalytic therapy due to their easy preparation and modification, tunable performance, excellent biocompatibility, and biodegradability.…”