A dual stimuli responsive natural polymer based superabsorbent hydrogel engineered through a novel cross-linker

Mehra, Saloni; Nisar, Safiya; Chauhan, Sonal; Singh, Gurmeet; Singh, Virender; Rattan, Sunita

doi:10.1039/d0py01729a

Cited by 18 publications

(7 citation statements)

References 69 publications

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“…To study the products’ crystallographic nature, the X-RD was performed on two samples (AT and SPHHs-AT-3) ( Figure S6c ). According to the spectra, amoxicillin trihydrate showed a broad peak at 15° because of the amorphous nature of the hydrogel; sharp peaks were observed at 2θ = 12.174, 15.134, 16.254, 17.218, 18.043° [ 54 ]. The figure shows the overlay diagram of the X-RD spectra of the drug and SPHHs-AT-3.…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Juthi

Wang

et al. 2023

Pharmaceutics

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Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.

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Section: Resultsmentioning

confidence: 99%

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Juthi

Wang

et al. 2023

Pharmaceutics

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“…In addition, PAA and PCC/PAA showed a broad peak at 22.0°, which was attributed to the crystal structure formed by the crosslinking of the polymer chains [ 42 ]. As the content of porous calcium carbonate increased to 4 wt%, the increased intensity of the peak at 22.0° implied that the porous calcium carbonate enhanced the crosslinking of the polyacrylic chains to ensure that the crosslinked network structure of PCC/PAA was not disrupted when fully extended [ 43 ]. However, as the porous calcium carbonate content increased from 4 wt% to 8 wt%, the peak intensity at 22.0° decreased, which was attributed to the increased crosslinking points, shortening the polyacrylic chain and inhibiting crosslinking.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Water Absorbency and Water Retention Rate for Superabsorbent Polymer via Porous Calcium Carbonate Crosslinking

Jiao,

Su,

Chen

et al. 2023

Nanomaterials

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To improve the water absorbency and water-retention rate of superabsorbent materials, a porous calcium carbonate composite superabsorbent polymer (PCC/PAA) was prepared by copolymerization of acrylic acid and porous calcium carbonate prepared from ground calcium carbonate. The results showed that the binding energies of C–O and C=O in the O 1s profile of PCC/PAA had 0.2 eV and 0.1–0.7 eV redshifts, respectively, and the bonding of –COO− groups on the surface of the porous calcium carbonate led to an increase in the binding energy of O 1s. Furthermore, the porous calcium carbonate chelates with the –COO− group in acrylic acid through the surface Ca2+ site to form multidirectional crosslinking points, which would increase the flexibility of the crosslinking network and promote the formation of pores inside the PCC/PAA to improve the water storage space. The water absorbency of PCC/PAA with 2 wt% porous calcium carbonate in deionized water and 0.9 wt% NaCl water solution increased from 540 g/g and 60 g/g to 935 g/g and 80 g/g, respectively. In addition, since the chemical crosslinker N,N′-methylene bisacrylamide is used in the polymerization process of PCC/PAA, N,N′-methylene bisacrylamide and porous calcium carbonate enhance the stability of the PCC/PAA crosslinking network by double-crosslinking with a polyacrylic acid chain, resulting in the crosslinking network of PCC/PAA not being destroyed after water absorption saturation. Therefore, PCC/PAA with 2 wt% porous calcium carbonate improved the water-retention rate by 244% after 5 h at 60 °C, and the compressive strength was approximately five-times that of the superabsorbent without porous calcium carbonate.

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“…The design of these novel materials is highly versatile and can be achieved through modification using graft polymerization techniques [ 22 ]. This approach introduces new chemical or stimulus-responsive properties to the base material [ 23 ], which can be very advantageous in drug delivery systems based on polymeric matrices, enhancing their biological efficacy [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Lignocellulosic Membranes Grafted with N-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin

Rentería-Urquiza,

Flores-Rojas,

Gómez-Lázaro

et al. 2024

Polymers

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Radiation chemistry presents a unique avenue for developing innovative polymeric materials with desirable properties, eliminating the need for chemical initiators, which can be potentially detrimental, especially in sensitive sectors like medicine. In this investigation, we employed a radiation-induced graft polymerization process with N-vinylcaprolactam (NVCL) to modify lignocellulosic membranes derived from Agave salmiana, commonly known as maguey. The membranes underwent thorough characterization employing diverse techniques, including contact angle measurement, degree of swelling, scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier-transform infrared-attenuated total reflectance spectroscopy (FTIR-ATR), nuclear magnetic resonance (CP-MAS 13C-NMR), X-ray photoelectron spectroscopy (XPS), and uniaxial tensile mechanical tests. The membranes’ ability to load and release an antimicrobial glycopeptide drug was assessed, revealing significant enhancements in both drug loading and sustained release. The grafting of PNVCL contributed to prolonged sustained release by decreasing the drug release rate at temperatures above the LCST. The release profiles were analyzed using the Higuchi, Peppas–Sahlin, and Korsmeyer–Peppas models, suggesting a Fickian transport mechanism as indicated by the Korsmeyer–Peppas model.

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A dual stimuli responsive natural polymer based superabsorbent hydrogel engineered through a novel cross-linker

Abstract: Natural protein-based polymers may serve as a potential source for developing advance porous organic macromolecules, possessing exquisite control over the pores, which impart exceptional properties to these materials. Here,...

Cited by 18 publications

References 69 publications

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Enhanced Water Absorbency and Water Retention Rate for Superabsorbent Polymer via Porous Calcium Carbonate Crosslinking

Lignocellulosic Membranes Grafted with N-Vinylcaprolactam Using Radiation Chemistry: Load and Release Capacity of Vancomycin

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