A dual center and dual vendor comparison study of automated perfusion‐weighted phase‐resolved functional lung magnetic resonance imaging with dynamic contrast‐enhanced magnetic resonance imaging in patients with cystic fibrosis

Behrendt, Lea; Smith, Laurie; Voskrebenzev, Andreas; Klimeš, Filip; Kaireit, Till F.; Pöhler, Gesa H.; Kern, A.; González, Cristian Crisosto; Dittrich, Anna‐Maria; Marshall, Helen; Schütz, Katharina; Hughes, Paul; Ciet, Pierluigi; Tiddens, Harm A.W.M.; Wild, Jim M.

doi:10.1002/pul2.12054

Cited by 17 publications

(22 citation statements)

References 43 publications

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“…Without detracting too much from the focus of this review, PREFUL derived perfusion measures have been used to study a variety of cohorts including healthy subjects and those with COPD, CTEPH and CF (16,256,258,272,273). Validation against dynamic contrastenhanced MRI (256,273,274), and repeatability have also been demonstrated (258).…”

Section: Free-breathing Proton Mrimentioning

confidence: 99%

Functional lung imaging using novel and emerging MRI techniques

et al. 2023

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Respiratory diseases are leading causes of death and disability in the world. While early diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools. Computed tomography is regarded as the gold standard for structural lung imaging but lacks functional information and involves significant radiation exposure. Lung magnetic resonance imaging (MRI) has historically been challenging due to its short T2 and low proton density. Hyperpolarised gas MRI is an emerging technique that is able to overcome these difficulties, permitting the functional and microstructural evaluation of the lung. Other novel imaging techniques such as fluorinated gas MRI, oxygen-enhanced MRI, Fourier decomposition MRI and phase-resolved functional lung imaging can also be used to interrogate lung function though they are currently at varying stages of development. This article provides a clinically focused review of these contrast and non-contrast MR imaging techniques and their current applications in lung disease.

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Section: Free-breathing Proton Mrimentioning

confidence: 99%

Functional lung imaging using novel and emerging MRI techniques

et al. 2023

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“…Recent publications show that chest MRI can be also used for automatic quantification of pulmonary disease in patients with CF and can detect progression of early CF lung disease in preschool-aged children 23,24 . Functional techniques such as Fourier decomposition, have been utilized in patients with CF to assess ventilation and perfusion without the need for contrast agents 25 . When implemented into clinical practice, MRI can provide information about ventilation, inflammation, perfusion and structure (VIPS-MRI) in one imaging session 25 …”

Section: Mri Of Pediatric Lungs and Airways: Past And Presentmentioning

confidence: 99%

“…23,24 Functional techniques such as Fourier decomposition, have been utilized in patients with CF to assess ventilation and perfusion without the need for contrast agents. 25 When implemented into clinical practice, MRI can provide information about ventilation, inflammation, perfusion and structure (VIPS-MRI) in one imaging session. 25…”

Section: Mri Evaluation Of Cystic Fibrosismentioning

confidence: 99%

Magnetic Resonance Imaging of Pediatric Lungs and Airways

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et al. 2023

Journal of Thoracic Imaging

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Disorders of the lungs and airways are among the most common indications for diagnostic imaging in infants and children. Traditionally, chest radiograph has been the first-line imaging test for detecting these disorders and when cross-sectional imaging is necessary, computed tomography (CT) has typically been the next step. However, due to concerns about the potentially harmful effects of ionizing radiation, pediatric imaging in general has begun to shift away from CT toward magnetic resonance imaging (MRI) as a preferred modality. Several unique technical challenges of chest MRI, including motion artifact from respiratory and cardiac motion as well as low signal-to-noise ratios secondary to relatively low proton density in the lung have slowed this shift in thoracic imaging. However, technical advances in MRI in recent years, including developments in non-Cartesian MRI data sampling methods such as radial, spiral, and PROPELLER imaging and the development of ultrashort TE and zero TE sequences that render CT-like high-quality imaging with minimal motion artifact have allowed for a shift to MRI for evaluation of lung and large airways in centers with specialized expertise. This article presents a practical approach for radiologists in current practice to begin to consider MRI for evaluation of the pediatric lung and large airways and begin to implement it in their practices. The current role for MRI in the evaluation of disorders of the pediatric lung and large airways is reviewed, and example cases are presented. Challenges for MRI of the lung and large airways in children are discussed, practical tips for patient preparation including sedation are described, and imaging techniques suitable for current clinical practice are presented.

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“…Gold standard measurements such as PFT were not collected for this study. However, the PREFUL technique has already been extensively evaluated against gold standards in dedicated studies, including PFT parameters, 13 perfusion single photon emission CT, 11 dynamic contrastenhanced MRI (DCE-MRI), [10][11][12] and 129 Xe ventilation MRI. 13 With the PFT not being spatially resolved and their correlation with the PREFUL parameters already established, 13 PFT measurements were not included for the specific purpose of this preliminary study.…”

Section: Acknowledgmentsmentioning

confidence: 99%

Free-Breathing Low-Field MRI of the Lungs Detects Functional Alterations Associated With Persistent Symptoms After COVID-19 Infection

et al. 2022

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Objectives: With the COVID-19 pandemic, repetitive lung examinations have become necessary to follow-up symptoms and associated alterations. Low-field MRI, benefiting from reduced susceptibility effects, is a promising alternative for lung imaging to limit radiations absorbed by patients during CT examinations, which also have limited capability to assess functional alterations. The aim of this investigative study was to explore the functional abnormalities that free-breathing 0.55 T MRI in combination with the phase-resolved functional lung (PREFUL) analysis could identify in patients with persistent symptoms after COVID-19 infection. Materials and Methods: Seventy-four COVID-19 patients and 8 healthy volunteers were prospectively scanned in free-breathing with a balanced steady-state free-precession sequence optimized at 0.55 T, 5 months postinfection on average. Normalized perfusion (Q), fractional ventilation (FV), and flow-volume loop correlation (FVLc) maps were extracted with the PREFUL technique. Q, FV, and FVLc defects as well as defect overlaps between these metrics were quantified. Morphological turbo-spin-echo images were also acquired, and the extent of abnormalities was scored by a board-certified radiologist. To investigate the functional correlates of persistent symptoms, a recursive feature elimination algorithm was applied to find the most informative variables to detect the presence of persistent symptoms with a logistic regression model and a cross-validation strategy. All MRI metrics, sex, age, body mass index, and the presence of preexisting lung conditions were included. Results: The most informative variables to detect persistent symptoms were the percentage of concurrent Q and FVLc defects and of areas free of those defects. A detection accuracy of 71.4% was obtained with these 2 variables when fitting the model on the entire dataset. Although none of the single variables differed between patients with and without persistent symptoms ( P > 0.05), the combined score of these 2 variables did ( P < 0.02). This score also showed a consistent increase from healthy volunteers (7.7) to patients without persistent symptoms (8.2) and with persistent symptoms (8.6). The morphological abnormality score showed poor correlation with the functional parameters.Conclusions: Functional pulmonary examinations using free-breathing 0.55 T MRI with PREFUL analysis revealed potential quantitative markers of impaired lung function in patients with persistent symptoms after COVID-19 infection, potentially complementing morphologic imaging. Future work is needed to explore the translational relevance and clinical implication of these findings.

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A dual center and dual vendor comparison study of automated perfusion‐weighted phase‐resolved functional lung magnetic resonance imaging with dynamic contrast‐enhanced magnetic resonance imaging in patients with cystic fibrosis

Cited by 17 publications

References 43 publications

Functional lung imaging using novel and emerging MRI techniques

Functional lung imaging using novel and emerging MRI techniques

Magnetic Resonance Imaging of Pediatric Lungs and Airways

Free-Breathing Low-Field MRI of the Lungs Detects Functional Alterations Associated With Persistent Symptoms After COVID-19 Infection

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