Functional lung imaging using novel and emerging MRI techniques

Foo, Chuan T.; Langton, David; Thompson, Bruce; Thien, Francis

doi:10.3389/fmed.2023.1060940

Cited by 6 publications

(2 citation statements)

References 279 publications

(416 reference statements)

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“…Last but not least, MRI does not involve ionizing radiation; however, in order to achieve perfusion scans, patients are infused with contrast medium (gadolin), which poses a risk of adverse events. The emerging novel techniques: oxygenenhanced MRI, Fourier decomposition MRI, and phase-resolved functional lung MRI (PREFUL) might provide us in the future with safer and equally effective diagnostic modalities for monitoring bronchopulmonary disease in people with CF [39].…”

Section: Discussionmentioning

confidence: 99%

MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis

Wojsyk-Banaszak,

Więckowska,

Szczepankiewicz

et al. 2023

JCM

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Magnetic resonance imaging (MRI) of the chest is becoming more available in the detection and monitoring of early changes in lung function and structure in patients with cystic fibrosis (CF). The aim of this study was to assess the relationship between pulmonary function tests (PFT) and perfusion deficits in CF children measured by MRI. We performed a retrospective analysis of the perfusion lung MRI scans and the results of spirometry, oscillometry, body plethysmography, single-breath carbon monoxide uptake, and multiple-breath washout technique (MBW). There were statistically significant correlations between the MRI perfusion scores and MBW parameters (2.5% LCI, M1/M0, M2/M0), spirometry parameters (FEV1, FVC, FEF25/75), reactance indices in impulse oscillometry (X5Hz, X10Hz), total lung capacity (TLC) measured in single breath carbon monoxide uptake, markers of air-trapping in body plethysmography (RV, RV/TLC), and the diffusing capacity of the lungs for carbon monoxide. We also observed significant differences in the aforementioned PFT variables between the patient groups divided based on perfusion scores. We noted a correlation between markers of functional lung deficits measured by the MRI and PFTs in CF children. MRI perfusion abnormalities were reflected sooner in the course of the disease than PFT abnormalities.

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Section: Discussionmentioning

confidence: 99%

MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis

Wojsyk-Banaszak,

Więckowska,

Szczepankiewicz

et al. 2023

JCM

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“…[20] and its first application in humans was published by Mugler et al [31]. The primary focus has been on applications in lung studies [29,[32][33][34][35][36][37][38][39][40], which utilize a direct visualization of the inhaled xenon gas. In 2023, Polarean Imaging Plc reached a significant milestone in a momentous stride toward the clinical application of HP 129 Xe MRI with the FDA approval of their XENOVIEW system [41].…”

Section: Hyperpolarized 129 Xe Mrimentioning

confidence: 99%

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Batarchuk,

Shepelytskyi,

Grynko

et al. 2024

IJMS

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Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine in full concordance with personalized medicine. A wide range of hyperpolarized (HP) 129Xe biosensors have been recently developed, demonstrating their potential applications in molecular settings, and achieving notable success within in vitro studies. The favorable nuclear magnetic resonance properties of 129Xe, coupled with its non-toxic nature, high solubility in biological tissues, and capacity to dissolve in blood and diffuse across membranes, highlight its superior role for applications in molecular MRI settings. The incorporation of reporters that combine signal enhancement from both hyperpolarized 129Xe and chemical exchange saturation transfer holds the potential to address the primary limitation of low sensitivity observed in conventional MRI. This review provides a summary of the various applications of HP 129Xe biosensors developed over the last decade, specifically highlighting their use in MRI. Moreover, this paper addresses the evolution of in vivo applications of HP 129Xe, discussing its potential transition into clinical settings.

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Retrospectively gated ultrashort‐echo‐time MRI T₁ mapping reveals compromised pulmonary microvascular NO‐dependent function in a murine model of acute lung injury

Kwiatkowski,

Czyzynska‐Cichon,

Tielemans

et al. 2024

NMR in Biomedicine

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This study sought to develop noninvasive, in vivo imaging schemes that allow for quantitative assessment of pulmonary microvascular functional status based on the combination of pulmonary T1 mapping and dynamic contrast‐enhanced (DynCE) imaging.Ultrashort‐echo‐time (UTE) imaging at 9.4 T of lung parenchyma was performed. Retrospective gating was based on modulation of the first point in each recorded spoke. T1 maps were obtained using a series of five consecutive images with varying RF angles and analyzed with the variable flip angle approach. The obtained mean T1 lung value of 1078 ± 38 ms correlated well with previous reports. Improved intersession variability was observed, as evident from a decreased standard deviation of motion‐resolved T1 mapping (F‐test = 0.051). Animals received lipopolysaccharide (LPS) and were imaged at t = 2, 6, and 12 h after administration. The nitric oxide (NO)‐dependent function was assessed according to changes in lung T1 after L‐NAME injection, while microvascular perfusion and oxidant stress were assessed with contrast‐enhanced imaging after injection of gadolinium or 3‐carbamoyl‐proxyl nitroxide radical, respectively.Retrospectivel gated UTE allowed robust, motion‐compensated imaging that could be used for T1 mapping of lung parenchyma. Changes in lung T1 after L‐NAME injection indicated that LPS induced overproduction of NO at t = 2 and 6 h after LPS, but NO‐dependent microvascular function was impaired at t = 12 h after LPS. DynCE imaging at t = 6 h after LPS injection revealed decreased microvascular perfusion, with increased vascular permeability and oxidant stress.MRI allows to visualize and quantify lung microvascular NO‐dependent function and its concomitant impairment during acute respiratory distress syndrome development with high sensitivity. UTE T1 mapping appears to be sensitive and useful in probing pulmonary microvascular functional status.

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Functional lung imaging using novel and emerging MRI techniques

Cited by 6 publications

References 279 publications

MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis

MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Retrospectively gated ultrashort‐echo‐time MRI T₁ mapping reveals compromised pulmonary microvascular NO‐dependent function in a murine model of acute lung injury

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Functional lung imaging using novel and emerging MRI techniques

Cited by 6 publications

References 279 publications

MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis

MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Retrospectively gated ultrashort‐echo‐time MRI T1 mapping reveals compromised pulmonary microvascular NO‐dependent function in a murine model of acute lung injury

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Retrospectively gated ultrashort‐echo‐time MRI T₁ mapping reveals compromised pulmonary microvascular NO‐dependent function in a murine model of acute lung injury