A double recombinant herpes virus of turkeys for the protection of chickens against Newcastle, infectious laryngotracheitis and Marek’s diseases

Gergen, Linda; Cook, Stephanie; Ledesma, Brooke; Cress, Wade; Higuchi, Deb; Counts, Diane; Cruz-Coy, Julio; Crouch, Colin; Davis, Phillip; Tarpey, Ian; Morsey, Mo

doi:10.1080/03079457.2018.1546376

Cited by 23 publications

(16 citation statements)

References 29 publications

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“…Similarly the construct was stable and safe even after 8 chicken egg passages (Yu et al 2020). The F gene of NDV, gD and gI genes of ILTV double recombinant HVT vector vaccine ((HVT-NDV-ILT) showed 97%, 94% and 97% protection against velogenic NDV (GB Texas), ILTV (LT 96-3) and Marek's disease virus (GA 5) strains, respectively (Gergen et al 2019). The advantages of these recombinant vaccines are lack of transmission, the absence of reversion to a virulent form, and lack of latency (Johnson et al 2010;Zhao et al 2014).…”

Section: Vaccinationmentioning

confidence: 96%

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Gowthaman

Kumar

Koul

et al. 2020

Veterinary Quarterly

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Infectious laryngotracheitis (ILT) is a highly contagious upper respiratory tract disease of chicken caused by a Gallid herpesvirus 1 (GaHV-1) belonging to the genus Iltovirus, and subfamily Alphaherpesvirinae within Herpesviridae family. The disease is characterized by conjunctivitis, sinusitis, oculo-nasal discharge, respiratory distress, bloody mucus, swollen orbital sinuses, high morbidity, considerable mortality and decreased egg production. It is well established in highly dense poultry producing areas of the world due to characteristic latency and carrier status of the virus. Co-infections with other respiratory pathogens and environmental factors adversely affect the respiratory system and prolong the course of the disease. Latently infected chickens are the primary source of ILT virus (ILTV) outbreaks irrespective of vaccination. Apart from conventional diagnostic methods including isolation and identification of ILTV, serological detection, advanced biotechnological tools such as PCR, quantitative real-time PCR, next generation sequencing, and others are being used in accurate diagnosis and epidemiological studies of ILTV. Vaccination is followed with the use of conventional vaccines including modified live attenuated ILTV vaccines, and advanced recombinant vector vaccines expressing different ILTV glycoproteins, but still these candidates frequently fail to reduce challenge virus shedding. Some herbal components have proved to be beneficial in reducing the severity of the clinical disease. The present review discusses ILT with respect to its current status, virus characteristics, epidemiology, transmission, pathobiology, and advances in diagnosis, vaccination and control strategies to counter this important disease of poultry.

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Section: Vaccinationmentioning

confidence: 96%

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Gowthaman

Kumar

Koul

et al. 2020

Veterinary Quarterly

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“…A double HVT vector vaccine designated HVT-ND-IBD (also known as strain HVP360, marketed as Inno-vax®-ND-IBD), which contains both the NDV-F gene and the IBDV VP-2 gene with regulatory sequences, was constructed using overlapping clones as described before (Gergen et al, 2019). First, the insertion plasmid was constructed.…”

Section: Construction Of the Hvt Vector Vaccine Virusmentioning

confidence: 99%

“…Turkey herpesvirus (HVT), also known as Meleagrid herpesvirus 1, belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Mardivirus and has been used since the 1970s as a vaccine to provide protection against Marek's disease (MD) (Okazaki et al, 1970). HVT is a naturally apathogenic virus, very safe for use in birds, stimulates humoral and cellular immunity, induces life-long protection, overcomes maternally-derived antibodies and has the capacity to accept foreign gene insertions in multiple sites (Gergen et al, 2019). This has led to the use of HVT as a vector platform for the development of HVT construct vaccines for many different poultry diseases.…”

Section: Introductionmentioning

confidence: 99%

“…It is not possible to combine different monovalent HVT vaccines in one vaccination as this can lead to interference (Dunn et al, 2019). To provide protection against multiple diseases with a single HVT vaccination, we recently described a HVT construct vaccine, HVT-NDV-ILT, that expresses antigens from both NDV and ILTV, and demonstrated its utility in simultaneous protection against ILT, ND and MD (Gergen et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Lentogenic NDV strains produce mild respiratory illness with little or no mortality, and some strains are commonly used as live vaccines (Morgan et al, 1992;Miller & Koch, 2013). Several HVT construct vaccines are available and have been demonstrated to provide high protection against ND (Sondermeijer et al, 1993;Rauw et al, 2010;Gergen et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a turkey herpesvirus double construct vaccine (HVT-ND-IBD) against challenge with different strains of Newcastle disease, infectious bursal disease and Marek’s disease viruses

Hulten¹,

Cruz-Coy²,

Gergen³

et al. 2020

Avian Pathology

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A double construct vaccine of turkey herpesvirus (HVT) was prepared that contains the fusion (F) gene from Newcastle disease virus (NDV) and the viral protein 2 (VP2) gene from infectious bursal disease virus (IBDV). Safety of the vaccine (HVT-ND-IBD) was confirmed and efficacy was evaluated after subcutaneous (SC) vaccination at 1 day of age or the in ovo route of vaccination. Challenges were performed with velogenic NDV strains (Texas GB and Herts Weybridge 33/56), with different strains of IBDV (classical strain STC; very virulent strain CS89 and variant E strain) and with Marek's disease virus (MDV) strain RB1B. Vaccination with HVT-ND-IBD induced a high level of protection against these challenges. Vaccination with HVT is often combined with Rispens CVI988 vaccine and live ND vaccines for higher and earlier, MD and ND protection, respectively. HVT-ND-IBD vaccination in combination with these vaccines showed MD protection as early as 4 days post vaccination and ND protection as early as 2 weeks post vaccination. The long protection as seen with HVT vaccination was confirmed by demonstrating protection against NDV up to 60 weeks. Finally, to evaluate the performance of the vaccine in commercial birds with maternally-derived antibodies, two field trials were performed, using in ovo vaccination in broilers and SC vaccination in combination with Rispens CVI988 vaccine in layer-type birds. The efficacy was confirmed for all components by challenges. These results demonstrate that HVT-ND-IBD is a safe and highly efficacious vaccine for simultaneous control of ND, IBD and MD. RESEARCH HIGHLIGHTS. A double construct HVT vaccine with the NDV F and the IBDV VP2 genes was prepared.. The vaccine protects against three important diseases: MDV, NDV and IBDV.. In ovo and sub-cutaneous vaccination was evaluated in the field in commercial chickens.

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Practical aspects of poultry vaccination

Wit

Montiel²

2022

Avian Immunology

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A double recombinant herpes virus of turkeys for the protection of chickens against Newcastle, infectious laryngotracheitis and Marek’s diseases

Cited by 23 publications

References 29 publications

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Efficacy of a turkey herpesvirus double construct vaccine (HVT-ND-IBD) against challenge with different strains of Newcastle disease, infectious bursal disease and Marek’s disease viruses

Practical aspects of poultry vaccination

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