1993
DOI: 10.1016/0006-3223(93)90007-z
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A double-blind trial of melatonin as a treatment for jet lag in international cabin crew

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Cited by 178 publications
(91 citation statements)
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“…20 Melatonin is used widely by the public as an over-the-counter supplement in the management of sleep disorders including insomnia and jet lag. [6][7][8]10 Though melatonin consumption is generally considered to be of little risk, there have been reports of interaction of melatonin with other botanical and medicinal products, as well as negative side effects if taken in excess in the short term. [21][22][23][24][25] In contrast with melatonin, serotonin has much more significant health concerns if taken in excess, leading to a condition known as serotonin syndrome, which ranges from very mild to fatal in its outcome, which can be exacerbated by interactions with other medications, such as selective serotonin reuptake inhibitors (SSRIs) and the analgesic tramadol.…”
Section: A B C Dmentioning
confidence: 99%
“…20 Melatonin is used widely by the public as an over-the-counter supplement in the management of sleep disorders including insomnia and jet lag. [6][7][8]10 Though melatonin consumption is generally considered to be of little risk, there have been reports of interaction of melatonin with other botanical and medicinal products, as well as negative side effects if taken in excess in the short term. [21][22][23][24][25] In contrast with melatonin, serotonin has much more significant health concerns if taken in excess, leading to a condition known as serotonin syndrome, which ranges from very mild to fatal in its outcome, which can be exacerbated by interactions with other medications, such as selective serotonin reuptake inhibitors (SSRIs) and the analgesic tramadol.…”
Section: A B C Dmentioning
confidence: 99%
“…Estimations of core body temperature minimum are based upon known relationships with respect to habitual wake time, prompting one to estimate core body temperature minimum timing either 2 or 3 hours prior to sleep offset, depending upon whether one typically sleeps up to 7 hours or more than 7 hours, respectively. [24][25][26] Travel to the west generally favors phase delays, which can be achieved in approximately 2-hour increments (reflecting the greater ease of delaying the clock), by following similar principles. In the opposite pattern, subjects expose themselves to light for approximately 3 hours prior to the core body temperature minimum and avoid light for approximately three hours thereafter (see Figure 3 as an example).…”
Section: Timed Light Exposurementioning
confidence: 99%
“…24,25 Immediate-release preparations appear to perform better than controlled-release formulations. 26 Although most studies have examined the efficacy of melatonin for jet lag occurring subsequent to eastward travel, [26][27][28][29] a single study examined its use in travel to the west and found it to be efficacious.…”
Section: Nocturnal Medication Administration For Jet Lagmentioning
confidence: 99%
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