A double‐blind, randomized trial of pyridoxine versus placebo for the prevention of pegylated liposomal doxorubicin‐related hand‐foot syndrome in gynecologic oncology patients

Abstract

A different series of new polystyrene–clay nanocomposites have been prepared by grafting polymerization of styrene with vinyl‐montmorillonite (MMT) clay. The synthesis was achieved through two steps. The first step is the modification of clay with the vinyl monomers, such as N,N‐dimethyl‐n‐octadecyl‐4‐vinylbenzyl‐ammonium chloride, n‐octadecyl‐4‐vinylbenzyl‐ammonium chloride, triphenyl‐4‐vinylbenzyl‐phosphonium chloride, and tri‐n‐butyl‐4‐vinylbenzyl‐phosphonium chloride. The second step is the polymerization of styrene with different ratios of vinyl‐MMT clay. The materials produced were characterized by different physical and chemical methods: (1) IR spectra, confirming the intercalation of the vinyl‐cation within the clay interlayers; (2) thermogravimetric analysis (TGA), showing higher thermal stability for PS–nanocomposites than polystyrene (PS) and higher thermal stability of nanocomposites with of phosphonium moieties than nanocomposites with ammonium moieties; (3) swelling measurements in different organic solvents, showing that the swelling degree in hydrophobic solvents increases as the clay ratio decreases; (4) X‐ray diffraction (XRD), illustrating that the nanocomposites were exfoliated at up to a 25 wt % of organoclay content; and (5) scanning electron microscopy (SEM), showing a complete dispersion of PS into clay galleries. Also, transmission electron microscopy (TEM) showed nanosize spherical particles of ∼ 150–400 nm appearing in the images. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 3739–3750, 2007

Skin toxicity in a patient with ovarian cancer treated with pegylated liposomal doxorubicin: A case report and review of the literature

“…The use of topical antiperspirant with a beneficial effect has also been reported in the literature (17). Pyridoxine appeared to be a promising agent for the prevention of PPE, but in randomized controlled trials, it proved to be ineffective (18,19). In a meta-analysis conducted by Macedo et al (16), celecoxib exclusively demonstrated a 53% risk reduction (odds ratio, 0.47; 95% confidence interval, 0.29-0.78; P= 0.003) of any grade PPE.…”

HFS-14, a Specific Quality of Life Scale Developed for Patients Suffering from Hand–Foot Syndrome

“…Published data on the impact of HFS on patient QoL are scarce. One study evaluating the incidence of HFS in gynecologic cancer patients treated with pegylated doxorubicin chemotherapy did not show the HFS condition to disrupt patient-rated QoL [21]. QoL measurement was performed with the Functional Assessment of Cancer Therapy-General (FACT-G) scale, a validated and reliable tool to measure QoL impairment related to cancer [22], which does not, however, specifically assess the impact of chemotherapeutic treatment-related HFS on QoL.…”

“…QoL measurement was performed with the Functional Assessment of Cancer Therapy-General (FACT-G) scale, a validated and reliable tool to measure QoL impairment related to cancer [22], which does not, however, specifically assess the impact of chemotherapeutic treatment-related HFS on QoL. In that study, the FACT-G scale failed to show a difference in QoL according to HFS grade [21], which underlines the need for the development of a specific scale. Only one published study assessed the impact of HFS on QoL in 12 cancer patients treated with sorafenib or sunitinib using a dermatologic scale [10].…”

Polymersome-Mediated Delivery of Combination Anticancer Therapy to Head and Neck Cancer Cells: 2D and 3D in Vitro Evaluation

“…However, Doxil® therapy is not without its own side-effects as its use has resulted in hand-foot syndrome in some patients 6 . These adverse effects are mitigated by using non-PEGylated liposomal formulations such as Myocet® 7 .…”