2010
DOI: 10.1002/cncr.25262
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A double‐blind, randomized trial of pyridoxine versus placebo for the prevention of pegylated liposomal doxorubicin‐related hand‐foot syndrome in gynecologic oncology patients

Abstract: A different series of new polystyrene–clay nanocomposites have been prepared by grafting polymerization of styrene with vinyl‐montmorillonite (MMT) clay. The synthesis was achieved through two steps. The first step is the modification of clay with the vinyl monomers, such as N,N‐dimethyl‐n‐octadecyl‐4‐vinylbenzyl‐ammonium chloride, n‐octadecyl‐4‐vinylbenzyl‐ammonium chloride, triphenyl‐4‐vinylbenzyl‐phosphonium chloride, and tri‐n‐butyl‐4‐vinylbenzyl‐phosphonium chloride. The second step is the polymerization … Show more

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Cited by 44 publications
(33 citation statements)
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“…The use of topical antiperspirant with a beneficial effect has also been reported in the literature (17). Pyridoxine appeared to be a promising agent for the prevention of PPE, but in randomized controlled trials, it proved to be ineffective (18,19). In a meta-analysis conducted by Macedo et al (16), celecoxib exclusively demonstrated a 53% risk reduction (odds ratio, 0.47; 95% confidence interval, 0.29-0.78; P= 0.003) of any grade PPE.…”
Section: Discussionmentioning
confidence: 92%
“…The use of topical antiperspirant with a beneficial effect has also been reported in the literature (17). Pyridoxine appeared to be a promising agent for the prevention of PPE, but in randomized controlled trials, it proved to be ineffective (18,19). In a meta-analysis conducted by Macedo et al (16), celecoxib exclusively demonstrated a 53% risk reduction (odds ratio, 0.47; 95% confidence interval, 0.29-0.78; P= 0.003) of any grade PPE.…”
Section: Discussionmentioning
confidence: 92%
“…Published data on the impact of HFS on patient QoL are scarce. One study evaluating the incidence of HFS in gynecologic cancer patients treated with pegylated doxorubicin chemotherapy did not show the HFS condition to disrupt patient-rated QoL [21]. QoL measurement was performed with the Functional Assessment of Cancer Therapy-General (FACT-G) scale, a validated and reliable tool to measure QoL impairment related to cancer [22], which does not, however, specifically assess the impact of chemotherapeutic treatment-related HFS on QoL.…”
Section: Discussionmentioning
confidence: 99%
“…QoL measurement was performed with the Functional Assessment of Cancer Therapy-General (FACT-G) scale, a validated and reliable tool to measure QoL impairment related to cancer [22], which does not, however, specifically assess the impact of chemotherapeutic treatment-related HFS on QoL. In that study, the FACT-G scale failed to show a difference in QoL according to HFS grade [21], which underlines the need for the development of a specific scale. Only one published study assessed the impact of HFS on QoL in 12 cancer patients treated with sorafenib or sunitinib using a dermatologic scale [10].…”
Section: Discussionmentioning
confidence: 99%
“…However, Doxil® therapy is not without its own side-effects as its use has resulted in hand-foot syndrome in some patients 6 . These adverse effects are mitigated by using non-PEGylated liposomal formulations such as Myocet® 7 .…”
Section: Introductionmentioning
confidence: 99%