HFS-14, a Specific Quality of Life Scale Developed for Patients Suffering from Hand–Foot Syndrome

Sibaud, Vincent; Dalenc, Florence; Chevreau, Christine; Roché, Henri; Delord, Jean‐Pierre; Mourey, Loïc; Lacaze, Jean‐Louis; Rahhali, Nora; Taïeb, C.

doi:10.1634/theoncologist.2011-0033

Cited by 83 publications

(55 citation statements)

References 21 publications

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“…This would allow early modification of cancer treatment and initiation of symptomatic therapy to avoid further treatment modification. 9 Even after 30 years of reports related to this adverse event, scarce information points to an effective treatment or prevention. Furthermore, with the advent of new drugs such as multikinase inhibitors in this era of targeted therapy, the presence of HFS shall remain a limiting factor for more years to come.…”

Section: Discussionmentioning

confidence: 99%

Two cases of palmar-plantar erythrodysesthesia induced by capecitabine

Mugada

Prashanth

Machara

2016

Int J Basic Clin Pharmacol

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Section: Discussionmentioning

confidence: 99%

Two cases of palmar-plantar erythrodysesthesia induced by capecitabine

Mugada

Prashanth

Machara

2016

Int J Basic Clin Pharmacol

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“…The total score is calculated by summing the item scores, with a maximum score of 100 and a minimum score of 2. A higher score indicates poorer QOL (23).…”

Section: Measurementsmentioning

confidence: 99%

“…The original version of the HFS-14 targeted patients who had already developed HFS (23). We made a small change to the original HFS-14 with permission from the original author to detect the development and progression of HFS (24); the limb involvement question was changed to add a score of 0 (no HFS symptoms) to the options, and we added a brief explanation of HFS to the introductory portion of the questionnaire.…”

Section: Measurementsmentioning

confidence: 99%

“…In this method, the answer choices of 'very painful' and 'moderately painful' for items assessing pain in the Japanese HFS-14 version were both modified to 'yes' (score of 1), while 'not painful' was replaced with 'no' (score of 0). Additionally, for the other HFS-14 items, the answer choices of 'always' and 'from time to time' were replaced with 'yes' (score of 1), while 'never' was replaced with 'no' (score of 0) (23,24).…”

Section: Development Of a Simple Self-monitoring Tool Based On The Hfmentioning

confidence: 99%

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A simple home-based self-monitoring tool for early detection of hand-foot syndrome in cancer patients

Mikoshiba

Yamamoto‐Mitani

Ohki

et al. 2016

Japanese Journal of Clinical Oncology

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Objective: Development of hand-foot syndrome symptoms, which is a common adverse effect of several cancer chemotherapy agents, can result in patient withdrawal from treatment. Its early identification allows appropriate modification of chemotherapy regimens and can avert treatment withdrawal by minimizing the impact on quality of life and duration of discontinued therapy. We sought to develop a simple home-based self-monitoring tool to facilitate reliable early identification of hand-foot syndrome, based on the self-administered quality of life questionnaire hand-foot syndrome-14. Methods: We modified the hand-foot syndrome-14 to create a simple tool with binary responses ('yes' or 'no') for patients to self-evaluate subjective hand-foot syndrome symptoms daily. We evaluated this tool with 187 consecutive, consenting, eligible adult patients attending four centers and treated with capecitabine, sorafenib or sunitinib for various cancers. Univariate and multivariate logistic regression analyses were used to select the items with the greatest discrimination for detecting Common Terminology Criteria for Adverse Events (CTCAE) grade 2 or 3 reactions, which indicate the need to modify the treatment regimen. Results: There were four items that were most strongly associated with Common Terminology Criteria for Adverse Events grade 2 or higher symptoms. 'Pain associated with hand-foot syndrome' was the most strongly associated with moderate hand-foot syndrome. For detecting moderate handfoot syndrome symptoms, the sensitivity was 100.0%, specificity was 94.6%, positive predictive value was 82.6% and area under the curve was 0.98 by a sum of the scores of four-item self-monitoring tool with cut-off value. Conclusions: We present a simple self-monitoring tool that can be used at home with high sensitivity and specificity for identifying grade 2 hand-foot syndrome. In addition, this tool might facilitate selfcare.

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“…HFS-14 is a self-administered questionnaire including 17 items that is specifically designed for assessment of QOL in patients with HFS [21]. Each item is scored on a three-point Likert scale: 0, "no, never"; 3, "yes, from time to time"; or 6, "yes, always".…”

Section: Measurement Of Quality Of Lifementioning

confidence: 99%

Relationship between Self-Care and Hand Foot Syndrome Specific Quality of Life in Cancer Patients

Mikoshiba¹,

Yamamoto‐Mitani²,

Sato³

et al. 2016

OJN

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Purpose: The purpose of this study was to describe adherence to self-care for hand-foot syndrome (HFS) and the relationship between self-care and health-related quality of life (QOL). Methods: A cross-sectional study was conducted on 105 consecutive outpatients with HFS. To assess self-care for HFS and QOL, the participants were asked to complete self-care and HFS-14 (hand-foot syndrome specific QOL) questionnaires, respectively. Multiple regression models were used to identify the relationship between self-care and QOL. Results: Adherence to self-care for HFS was low, less than 50% for most of the items. Multivariate analysis revealed that poorer self-care (βs = −0.19; P = 0.03), depressive symptoms (βs = 0.43; P < 0.0001), and being employed (βs = 0.20; P = 0.04) were independent predictors of poorer QOL scores. Conclusions: We have identified a need for further research to develop effective programs of self-care in HFS.

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HFS-14, a Specific Quality of Life Scale Developed for Patients Suffering from Hand–Foot Syndrome

Cited by 83 publications

References 21 publications

Two cases of palmar-plantar erythrodysesthesia induced by capecitabine

Two cases of palmar-plantar erythrodysesthesia induced by capecitabine

A simple home-based self-monitoring tool for early detection of hand-foot syndrome in cancer patients

Relationship between Self-Care and Hand Foot Syndrome Specific Quality of Life in Cancer Patients

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