A double-blind randomized clinical trial on the efficacy of magnetic sacral root stimulation for the treatment of Monosymptomatic Nocturnal Enuresis

Abstract

Purpose: Purpose of this study was to evaluate the long term efficacy of repetitive sacral root magnetic stimulation (rSMS) in patients with monosymptomatic nocturnal enuresis (MNE). Methods: Forty four patients were randomized to receive either sham or real repetitive sacral root magnetic stimulation (rSMS; 15 Hz with a total of 1500 pulses/session) for 10 sessions. Evaluation was performed before starting treatment, immediately after the 5th and 10th treatment session, and 1 month later, using frequency of enuresis/week, visual analogue scale (VAS) and quality of life as outcome measures. Resting and active motor thresholds of gastrocnemius muscles were measured before and after the end of sessions. Results: Both treatment and control groups were comparable for baseline measures of frequency of enuresis, and VAS. The mean number of wet nights/week was significantly reduced in patients who received real rSMS. This improvement was maintained 1 month after the end of treatment. Patients receiving real-rSMS also reported an improvement in VAS ratings and quality of life. A significant reduction of resting motor threshold was recorded after rSMS in the real group while no such changes were observed in the sham group. Conclusion: These findings suggest that rSMS has potential as an adjuvant treatment for MNE and deserves further study.

The effectiveness of magnetic stimulation for patients with pelvic floor dysfunction: A systematic review and meta‐analysis

“…Yamanishi et al compared MS with FES, Fergany et al compared MS with TENS, and remaining studies compared MS with sham. One study did not document the treatment of sham device, two studies used the 20.4% of active stimulation, two studies utilized the sham stimulating coil as the experimental group, one study applied 1 Hz as the sham stimulation, one study performed the sham stimulation with a thin deflective aluminium plate inserted in the chair, and remaining studies adopted stimulation with inactive device as the experimental group.…”

“…But et al found active MS treatment had significant improvement in number of leaks and bladder volume at strong desire to void ( P = 0.07, P = 0.022, respectively) with 2 month duration; with no change between the two groups in bladder capacity at first desire to void ( P = 0.059). One study by Khedr at al showed that there was a significant difference between the MS therapy and sham group in number of leaks, QOL, and VAS score, with a P ‐value of 0.001.…”

“…Finally, 20 RCTs met all eligibility criteria and were selected for this systematic review. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]…”

“…Two RCTs 38,40 were carried out in Egypt. Six RCTs 26,30,[32][33][34]41 were performed in New Zealand, Italy, Malaysia, United States, Switzerland, Germany, respectively.…”

Peripheral repetitive magnetic stimulation for the treatment of neurogenic urinary disorders: literature review and investigational study

“…• подавлению обратного нейронального захвата норадреналина и серотонина [45]; • стимуляции афферентных волокон пудендаль-ного нерва в составе крестцовых корешков [46]; • активации спинальной опиодной системы, подавляющей сокращения детрузора [47]; • стимуляции эфферентных волокон тазового нерва в составе крестцовых корешков [48]. В исследовании P. M. Braun и соавт.…”