A Double-Blind, Placebo-Controlled Study of Sertraline in the Prevention of Depression in Stroke Patients

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

“…With regard to risk-benefit assessment, SSRIs such as citalopram and fluoxetine have been shown to be effective in the treatment of post-stroke depression in randomized controlled trials (Robinson et al, 2000). In addition, sertraline has been found to be effective in the prevention of depression in stroke patients (Rasmussen, 2003), and fluoxetine appears to facilitate stroke recovery, even in nondepressed stroke patients (Dam et al, 1996). Neuronal recovery in stroke might be mediated through the effects exerted by SSRIs on brain-derived neurotrophic factor and neurogenesis (Duman et al, 1997).…”

Prevention of Major Depression in Complex Medically Ill Patients: Preliminary Results From a Randomized, Controlled Trial

“…Only a few studies have evaluated the primary prevention of depression in physically ill patients. 13,14 As recently argued, such strategies are feasible if an indicator for risk of depression exists. 15 On the basis of our previous work, 16 -18 we considered case complexity, a combination of several illness-related and psychosocial vulnerability factors, as an indicator for inclusion in a depression prevention program.…”

Post-Stroke Depression

“…Rasmussen c соавторами проводили профилактику с помощью сертралина против плацебо 137 пациентам после инсульта без депрессии. В группе пациентов, получавших сертралин 12 месяцев, депрессия возникала реже (10%), чем в группе плацебо (30%), однако эти данные были статистически не достовер-ны из-за малого числа пациентов, окончивших исследова-ние [23]. Almeida et al [24] также проводили профилактику ПД с помощью сертралина в течение 24 недель и не полу-чили достоверной разницы по сравнению с группой пла-цебо.…”