A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen

Спасов, А. А.; Wikman, G.; Мандриков, В Б; Mironova, I A; Neumoin, V.V.

doi:10.1016/s0944-7113(00)80078-1

Cited by 192 publications

(154 citation statements)

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“…This plant is very popular in traditional medicine, with a reputation for alleviating emotional, mental and physical disorders (German et al, 1999;Spasov et al, 2000;Shevtsov et al, 2003;Saratikov and Krasnov, 2004;Panossian and Wagner, 2005).…”

Section: Introductionmentioning

confidence: 99%

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

151

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Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.

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Section: Introductionmentioning

confidence: 99%

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

151

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“…Thus, the search for bioactive compounds that can regulate the activities of MMP-1, -2, and -9 from natural resources is one of the key steps in delaying skin aging. Rhodiola rosea L. (Crassulaceae), an herbaceous plant, is used in Asian and Eastern European traditional medicines for its pressure-reducing [4], neurosystem-stimulating [5], fatigue-removing [6], hypobaropathy-preventing [7], antidepressive [7], anticancer [8], antiaging [9], cardiovascular-protective [10], and hepatoprotective effects [11]. Chemical investigations on this plant have revealed many chemical entities, including phenolic acids [12], phenolethanoids [13], phenylpropenoids [14], flavonoids [15], monoterpenes [4], and glycosides [16].…”

mentioning

confidence: 99%

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

et al. 2016

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Introduction !Matrix metalloproteinases (MMPs) are a family of zinc-and calcium-dependent endopeptidases, which are grouped into the metzincin clan of metallopeptidases (MPs) together with other families such as ADAMs/adamalysins, astacins, fragilysins, and serralysins. MMPs are found throughout the animal and plant kingdoms, where their distribution is consistent with a Darwinian tree-based pathway [1]. Furthermore, polyplication has led to the presence of several paralogous MMP genes in the same organism: 24 in humans, 26 in sea urchins, 26 in zebrafish, 7 in sea squirts, and 2 in fruit flies. Overexpression of MMPs may cause various inflammatory, malignant, and degenerative symptoms [2]. Among the MMPs studied, gelatinase-A (MMP-2), gelatinase-B (MMP-9), and collagenase-1 (MMP-1) were reported to be responsible for the signal transduction of dermal photoaging [3], and inhibition of the activities of these two enzymes could potentially slow down skin aging. Thus, the search for bioactive compounds that can regulate the activities of MMP-1, -2, and -9 from natural resources is one of the key steps in delaying skin aging. [16]. In a preliminary biological evaluation, crude extracts of R. rosea roots exhibited inhibitory activities toward MMP-2 and collagenase at a concentration of 100 µg/mL [17]. An investigation of the active principles of this plant was thus undertaken by using a bioassayguided method. Of the tested water, n-butanol, and ethyl acetate layers, the ethyl acetate layer Abstract ! Based on the significant inhibitory activity toward matrix metalloproteinase-2 and collagenase noticed in preliminary studies, crude extracts of Rhodiola rosea were partitioned and chromatographed sequentially to afford three new compounds, 1,2,3,6-tetra-O-galloyl-4-O-p-hydroxybenzoyl-β-D-glucopyranoside (1), (E)-creoside I (2), and (R,Z)-2-methylhept-2-ene-1,6-diol (3), along with twenty-four known compounds (4-27). Their structures were determined by spectroscopic data analyses. All isolated compounds were subjected to bioactivity assays. In these, 1 specifically inhibited matrix metalloproteinase-2 activity with an IC 50 value of 16.3 ± 1.6 µM, while its analogue 1,2,3,6-tetra-O-galloyl-β-D-glucopyranonoside (17) inhibited matrix metalloproteinase-2 with an IC 50 value of 23.0 ± 4.8 µM. In the collagenase activity assay, the inhibitory effects of 1 and 17 at concentrations of both 20 and 40 µM were more potent than those of the positive control, 1,10-phenanthroline. In order to realize whether 17 could penetrate from the epidermal layer into the basal and dermal layers of the human skin to inhibit the activity of matrix metalloproteinase-2 and collagenase or not, a transdermal penetration test in nude and white mice skins was performed. Penetration percentages of 17 quantified by LC-MS were 27.8 % and 74.8 % in 24 hours, respectively. Supporting information available online at

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“…The study displayed statistical significance in physical fitness, mental fatigue, neuro-motoric tests (p< 0.01) and general well-being (p< 0.05) in 20 days (Spasov, Wikman, Mandrikov, Mironova, & Neumoin, 2000). Physical fitness was measured using two parameters: physical work capacity via the veloergonomic test PWC-170 and an increase in pulse rate following the ergometric test compared with the pulse rate just before.…”

Section: Rhodiolamentioning

confidence: 95%

The Effects of Adaptogens on the Physical and Psychological Symptoms of Chronic Stress

Ajala¹

2017

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A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen

Cited by 192 publications

References 2 publications

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

The Effects of Adaptogens on the Physical and Psychological Symptoms of Chronic Stress

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