The Effects of Adaptogens on the Physical and Psychological Symptoms of Chronic Stress

Ajala, Tosin O

doi:10.31922/disc4.2

Cited by 4 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their effect on the body is to help in coping with metabolic stress, so limiting the disturbance of internal homeostasis. [20] They improve the body's immune competence and resistance, so protecting against the deleterious effects of pathogens. In addition, they support the liver, so helping to oppose toxic influences from the diet or the environment.…”

Section: Desired Clinical Effectsmentioning

confidence: 99%

The Pharmacological Action of Common Herbal Remedies

Bhikha¹,

Glynn²

2018

AJIM

View full text Add to dashboard Cite

Acceptance of the clinical efficacy and tolerance of herbal remedies by practitioners of conventional, Western medicine is strongly dependent on unambiguous and reproducible evidence, particularly their pharmacological action. A single conventional drug generally has one dominant pharmacological mode of action which accounts for its therapeutic efficacy, whereas a herbal remedy because of the various active agents it contains, generally influences several biochemical and/or physiological systems present in the body. Identifying this therefore poses several challenges. They are much more complex, and the active components of a herbal remedy may act synergistically or interact in other ways. Although the need to determine modes of action has not been a primary concern of complementary healthcare practitioners, there is increasing pressure to elaborate objectively on their pharmacological action. In response, there has been an encouraging, and escalating, release of scientific data documenting the mode of action of many herbal remedies. Some we know about in considerable detail; of others we have an inkling; but for the vast majority the' modes of action remain to be elucidated. This brief review, based on a survey of the available scientific and clinical literature, examines the modes of action of several therapeutic herbs which are being increasingly used, whether informally or as part of complementary or integrative medical practice. It examines a major category of sub stances, the adaptogens, and the various chemical forms it embraces, such as the saponins and triterpenes. The herbs with modulate the immune system, for instance garlic, turmeric and St John's Wort, are likewise surveyed, as are the alkaloids and botanical anti-inflammatory agents. Herbs which exert pharmacological action via their nitric oxide regulatory properties are listed, as are those which provide essential micro-nutrients, such as vitamins and certain minerals. The review concludes with comment on the importance of understanding herbal remedy modes of action as a positive step to their wider adoption in the modern-day therapeutic armamentarium.

show abstract

Section: Desired Clinical Effectsmentioning

confidence: 99%

The Pharmacological Action of Common Herbal Remedies

Bhikha¹,

Glynn²

2018

AJIM

View full text Add to dashboard Cite

show abstract

“…EDITED BY the high concentrations of cortisol produced under prolonged uninterrupted stress not only jeopardize cardiovascular system function, but also cause dendritic atrophy of neurons, synaptic structure change, and neuronal apoptosis, which ultimately induces cognitive dysfunction (Ajala, 2017). In addition, exogenous GC may increase the risk of neurodegenerative diseases by promoting lactate dehydrogenase (LDH) release from hippocampal neurons and altering neuronal synaptic structure and function (Macpherson et al, 2005;Finsterwald et al, 2015).…”

Section: Open Accessmentioning

confidence: 99%

Protective effects and mechanisms of the Erzhi formula on glucocorticoid induced primary cortical neuron injury

Han

Han²,

Yan³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

High concentrations of glucocorticoids (GC) can cross the blood-brain barrier into the brain parenchyma, triggering a stress state that can lead to a range of physiological changes. This study investigated whether Erzhi formula has neuroprotective effects against glucocorticoid damage by establishing a dexamethasone-induced primary cortical neuron injury model in vitro. The results showed that Erzhi formula could reduce dexamethasone-induced apoptosis in primary cultured cortical neurons and improve synaptic damage. Further, network pharmacological analysis revealed that Erzhi formula may exert antidepressant effects by multi-component, multi-target, and multi-pathway characteristics, in which Salidroside, Biochanin-A and other ingredients are key components, HSD11B1, NR3C1, and other proteins are key targets, and steroid metabolism may be a key process in its action. Moreover, our study found that the neuroprotective effect of Erzhi formula might be related to the 11β-HSD1-GC/glucocorticoid receptor (GR) signaling pathway. The Erzhi formula could significantly inhibit the activity of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in vitro using homogeneous time-resolved fluorescence. In addition to providing evidence for the pharmacological effects of the Erzhi formula, the present study lays down the foundation for subsequent experiments.

show abstract

“…Current and potential uses of these medicinal plants are associated with mental diseases and behavioural disorders, cognitive function and stress-induced diseases (anxiety, cardiovascular diseases, diabetes) [4,9,[15][16][17][18][19][20]. The intake of plant adaptogens is not associated with serious side effects [20,21].…”

Section: Introductionmentioning

confidence: 99%

Plant Adaptogens—History and Future Perspectives

et al. 2021

View full text Add to dashboard Cite

Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to enhance the body’s stability against physical loads without increasing oxygen consumption. Extracts from Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis are considered to be naturally occurring adaptogens and, in particular, plant adaptogens. The aim of this study is to evaluate the use of plant adaptogens in the past and now, as well as to outline the prospects of their future applications. The use of natural adaptogens by humans has a rich history—they are used in recovery from illness, physical weakness, memory impairment, and other conditions. About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body’s resistance to stress and to improve physical endurance. Although now many people take plant adaptogens, the clinical trials on human are limited. The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection. In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.

show abstract

The Effects of Adaptogens on the Physical and Psychological Symptoms of Chronic Stress

Cited by 4 publications

References 32 publications

The Pharmacological Action of Common Herbal Remedies

The Pharmacological Action of Common Herbal Remedies

Protective effects and mechanisms of the Erzhi formula on glucocorticoid induced primary cortical neuron injury

Plant Adaptogens—History and Future Perspectives

Contact Info

Product

Resources

About