A Double-Blind Comparison of Two Different Treatments for Acute Enteritis in Adults

Camarri, E; Belvisi, A; Guidoni, G; Marini, G; G, Frigerio

doi:10.1159/000238017

Cited by 31 publications

(14 citation statements)

References 7 publications

(7 reference statements)

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“…Probably through protective action the probiotic supports the maintenance or stabilization of the normal microbial population during antibiotic treatment. These observations are in agreement of previous clinical tests on the influence of E. faecium SF68 in the treatment of intestinal disorders (3,5,8,20,25,27,31 …”

Section: Minimal Inhibitory Concentrations (Mic)supporting

confidence: 92%

A Modified Continuous Flow Culture System for Studying Microbial Interactions Related to the Gastro-Intestinal Tract: Application of the Probiotic Organism Enterococcus faecium SF68

Toit

Knöpfel

Skowronek

et al. 1998

Bioscience Microflora

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A modified continuous flow system was used to test the regulative effect of Enterococcus faecium SF68 on single strain cultures of Lactobacillus reuteri and Lactobacillus acidophilus representative of the autochthonous intestinal microflora. Experiments were conducted in duplicate using serially arranged fermentation cells. The second (A) and third (B) cells were filled with agar blocks containing an immobilized culture of either L. reuteri or L. acidophilus. The data obtained confirmed observations from previous clinical tests on the influence of E. faecium SF68 in the treatment of intestinal disorders. In our in vitro investigations with the continuous flow system E. faecium SF68 accelerated the restoration of the L. reuteri and L. acidophilus populations when applied after antibiotic treatment. The application of E. faecium SF68 together with the antibiotic had a protective effect on the L. reuteri and L. acidophilus populations, as cell numbers decreased at a significantly lower rate compared to the control unit.

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Section: Minimal Inhibitory Concentrations (Mic)supporting

confidence: 92%

A Modified Continuous Flow Culture System for Studying Microbial Interactions Related to the Gastro-Intestinal Tract: Application of the Probiotic Organism Enterococcus faecium SF68

Toit

Knöpfel

Skowronek

et al. 1998

Bioscience Microflora

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“…These results follow those of previous studies using LGG as a treatment for established diarrhea, which all used a treatment period of 2 to 7 days. [17][18][19]28,30,31,47,48 Previous meta-analyses of probiotic treatment for diarrhea showed a significant difference within 3 to 4 days, suggesting that 7 days should be sufficient to see an effect. 49 However, most of these studies were in children, not critically ill adults.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11] Many studies support the effectiveness of probiotics (particularly Lactobacillus rhamnosus GG [LGG] and Saccharomyces boulardii) in preventing antibiotic-associated diarrhea, [12][13][14][15] including in critically ill patients, 16 but in everyday clinical practice, it is more common to administer probiotics only once the diarrhea has started. Although there is some evidence that such treatment of established diarrhea can reduce the duration and/or severity of diarrhea in children, 17,18 there are very few supportive studies of probiotic therapy in adults with diarrhea 19,20 and no published studies of probiotics as a diarrhea treatment in critically ill patients.…”

mentioning

confidence: 99%

Lactobacillus GG as Treatment for Diarrhea During Enteral Feeding in Critical Illness

Ferrie

Daley

2010

J Parenter Enteral Nutr

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Background: Diarrhea is a common problem in critical illness. The aim of this study was to investigate the effect of probiotic treatment with Lactobacillus rhamnosus GG on established diarrhea in critically ill patients. Methods: This prospective randomized blinded trial in the adult intensive care unit of a large tertiary referral teaching hospital compared probiotic treatment with placebo. Thirty‐six consecutive critically ill enterally fed adults with diarrhea were randomized to receive 2 capsules per day for 7 days of either Lactobacillus GG in an inulin base (Culturelle) or inulin alone (placebo). Diarrhea was defined as ≥3 unformed stools or >200 mL stool volume within 24 hours. Prospectively defined primary end point was duration of diarrhea, and secondary end point was mean number of loose stools per day during the 14 days from the first capsule. Results by intention‐to‐treat analysis: No significant difference was observed for any end point. There was a trend toward more diarrhea in the probiotic treatment group. Mean (standard deviation) duration of diarrhea was 3.83 (2.39) days for the probiotic group and 2.56 (1.85) days for the placebo group (P = .096). Mean number of loose stools per day during the 14 days from the first capsule was 1.58 (0.88) in the probiotic group and 1.10 (0.79) in the placebo group (P = .150). Conclusions: This study does not support the use of Lactobacillus GG as a treatment for established diarrhea in enterally fed critically ill patients.

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“… 25 Mitra and Rabbani were not able to show any benefit of the administration of the Escherichia faecium strain SF68, in a 3‐day trial in comparison with administration of the placebo, in the treatment of adults with diarrhoea due to Vibrio cholerae and E. coli . 26 …”

Section: Probioticsmentioning

confidence: 99%

Probiotics in infective diarrhoea and inflammatory bowel diseases

Gionchetti

Rizzello

Venturi

et al. 2000

J of Gastro and Hepatol

119

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Bacteria are present throughout the gastrointestinal tract, but their pattern and concentration vary greatly. Probiotics are living organisms that supply beneficial health effects to the host. So far the beneficial effects of probiotics have been shown, almost exclusively, under poorly defined experimental conditions. There are little convincing data from well‐designed, double‐blind controlled trials supporting health‐promoting effects. The use of probiotics to treat gastrointestinal infections has produced contrasting results. Apart from information on rotavirus infection in children, there is no convincing evidence from controlled studies on the efficacy of probiotics in the prevention or treatment of infective diarrhoea. However, experimental and clinical studies suggest that there are potential therapeutic roles for probiotics in the treatment of inflammatory bowel diseases. This review focuses on the available data concerning the mechanisms of action of probiotics, and on the results from clinical studies using probiotics to treat infective diarrhoea and inflammatory bowel disease.

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A Double-Blind Comparison of Two Different Treatments for Acute Enteritis in Adults

Cited by 31 publications

References 7 publications

A Modified Continuous Flow Culture System for Studying Microbial Interactions Related to the Gastro-Intestinal Tract: Application of the Probiotic Organism Enterococcus faecium SF68

A Modified Continuous Flow Culture System for Studying Microbial Interactions Related to the Gastro-Intestinal Tract: Application of the Probiotic Organism Enterococcus faecium SF68

Lactobacillus GG as Treatment for Diarrhea During Enteral Feeding in Critical Illness

Probiotics in infective diarrhoea and inflammatory bowel diseases

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