A double-blind comparison of cephalexin and ampicillin in the treatment of bronchitis

Cooke, Deborah M.; Garrett, Rebecca

doi:10.1093/jac/1.suppl_3.99

Journal of Antimicrobial Chemotherapy

1975

DOI: 10.1093/jac/1.suppl_3.99

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A double-blind comparison of cephalexin and ampicillin in the treatment of bronchitis

Deborah M. Cooke¹,

Rebecca Garrett²

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1977

1987

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Lower Respiratory Tract Infections Treated with Bacampicillin: A Dose Comparison

Sjövall¹

1977

J Int Med Res

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In an open multicentre study of bacampicillin (Penglobe), a new orally well absorb ed prodrug of ampicillin, 516 patients with acute exacerbations of chronic bronchitis or pneumonia were treated by a group of Belgian pneumologists or internists. Bacampicillin was given in a dosage regimen of 400 mg or 800 mg three times daily. In patients with acute exacerbations of chronic bronchitis the clinical success rate was high, over 95% in both groups. An improvement in the sputum purulence score was seen in 93% of the patients with an initially purulent sputum and 69% had a normal mucoid sputum at follow-up. The clinical success rate in patients with pneumonia was also similar in both dosage groups with success rates over 96%. The total number of patients with adverse reactions was not more than 5-4%, of which the majority were considered mild or moderate. Each type of side-effect occurred in a frequency of 1-2% or less. There were no differences between the two dosage regiments as regards the frequency of side-effects indicates a remarkably good tolerance of bacampicillin also with the higher dosage.

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Lower Respiratory Tract Infections Treated with Bacampicillin: A Dose Comparison

Sjövall¹

1977

J Int Med Res

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Efficacy and Tolerance of Enteric-Coated Erythromycin Base (Ery-Max®) Administered Twice or Four Times Daily in Patients with Acute Bronchitis

Pekkanen¹,

Josefsson

1983

J Int Med Res

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We performed a double-blind trial of a new formulation of erythromycin base as enteric-coated pellets (Ery-Max) in the treatment of acute bronchitis in 220 patients. Subjects were randomized to receive either 500 mg twice or 250 mg four times a day for 10 days. The response to treatment as assessed clinically and by changes in sputum purulence was the same in the two groups. Thus 97% and 98% of the patients had a good or improved clinical effect. Treatment was well tolerated, but side-effects were encountered more often in the q.i.d. group (p greater than 0.05). In conclusion, the study showed that the enteric-coated erythromycin as pellets, given twice or four times daily for 10 days, was well tolerated and equally effective in acute bronchitis. Hence, the more convenient b.i.d. regimen can be recommended.

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Treatment of Respiratory Tract Infections with Cephalosporin Antibiotics

Finch

1987

Drugs

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A double-blind comparison of cephalexin and ampicillin in the treatment of bronchitis

Cited by 3 publications

References 0 publications

Lower Respiratory Tract Infections Treated with Bacampicillin: A Dose Comparison

Lower Respiratory Tract Infections Treated with Bacampicillin: A Dose Comparison

Efficacy and Tolerance of Enteric-Coated Erythromycin Base (Ery-Max®) Administered Twice or Four Times Daily in Patients with Acute Bronchitis

Treatment of Respiratory Tract Infections with Cephalosporin Antibiotics

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