A domestic porcine model for studying the effects of radiation on head and neck cancers

Arnold, C.; Kloss, Frank; Singh, Sarvpreet; Vasiljevic, Danijela; Stigler, Robert; Allmendinger, Thomas; Wenzel, Volker; Klima, G.; Lukáš, Peter; Lepperdinger, Günter; Gaßner, Robert

doi:10.1016/j.oooo.2016.11.017

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…Scrutinizing animal models instead may facilitate determination of safety and efficacy of new therapies [10–12]. Among animal tissues, porcine buccal gingiva obtained from abattoirs bears excellent histological resemblance when compared to human oral tissue [13].…”

Section: Introductionmentioning

confidence: 99%

“…Using live animals or working on human patients in research to date leads to a rise in costs and complicates obtaining new knowledge. Scrutinizing animal models instead may facilitate determination of safety and efficacy of new therapies [ 10 – 12 ]. Among animal tissues, porcine buccal gingiva obtained from abattoirs bears excellent histological resemblance when compared to human oral tissue [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of an ex vivo porcine model to investigate the effect of low abrasive airpolishing

Petersilka

Heckel²,

Koch³

et al. 2018

Clin Oral Invest

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ObjectivesEvaluation of an ex vivo porcine model to investigate the influence of periodontal instrumentation on soft tissue.Material and methodsIn each of 120 pig mandibles, one molar tooth was chosen at random and instrumented. For subgingival debridement, two different low abrasive airpolishing powders (glycine d90 = 25 μm, erythritol d90 = 14 μm, n = 30 teeth each), curets, and a piezoelectric ultrasonic scaler were used (n = 30 teeth each). Thirty teeth in 30 other mandibles served as the untreated control. Gingival biopsies were histologically assessed for destruction using a four-graded scale.ResultsThe porcine model was deemed suitable for the planned investigation. Hand instrumentation and ultrasonic scaling caused higher tissue damage than both low abrasive airpolishing modes (Fisher’s exact test, p = 0.0025). Glycine powder led to less, yet non-statistical noticeable gingival changes compared to erythritol-based powder (Fisher’s exact test, p = 0.39).ConclusionAn animal model using pig jaws may be used as a preliminary model to analyze histological effects of periodontal instrumentation in advance of studies performed in human tissues. Among the techniques assessed, low abrasive airpolishing (LAA) caused the smallest tissue damage.Clinical relevanceTo avoid gingival damage using LAA, histological observations of gingival tissue are needed. Since numerous powders for LAA have been developed and it may be expected that additional products will follow, it appears to be useful to establish ex vivo animal models to prove the powders safety.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of an ex vivo porcine model to investigate the effect of low abrasive airpolishing

Petersilka

Heckel²,

Koch³

et al. 2018

Clin Oral Invest

View full text Add to dashboard Cite

show abstract

“…A domestic mini-pig model for the study of radiation-induced tissue changes in the oral cavity was recently described (91). An earlier study assessed the effect of radiation on parotid salivary glands in mini-pigs (92).…”

Section: Porcine Modelmentioning

confidence: 99%

Non-murine models to investigate tumor-immune interactions in head and neck cancer

Rossa

D’Silva

2019

Oncogene

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The immune response has important roles in the biology of solid tumors, including oncogenesis, tumor growth, invasion and metastasis, and response to treatment. Improved understanding of tumor-immune system interactions has provided promising therapeutic options that are based on the rescue and enhancement of the anti-tumoral host response. Immune-based treatments have been approved for clinical use in various types of cancer, including head and neck cancer (HNC); other strategies involving combination therapies are currently in development. These novel therapies were developed based on knowledge derived from in vitro, in silico, and in vivo pre-clinical studies. However, clinical trials seldom replicate the efficacy observed in pre-clinical animal studies. This lack of correlation between pre-clinical studies and clinical trials may be related to limitations of the models used; which highlights the relevance of considering immune-related aspects of different pre-clinical models. Murine models are the most frequently used pre-clinical models of HNC and are discussed elsewhere. Non-murine models have characteristics that offer unique opportunities for the study of HNC etiology, therapeutic strategies, and tumor-immune system interactions. The current review focuses on immune-related aspects of non-murine models, including dog, cat, pig, zebrafish, and frog, that could be used to investigate tumor-immune interactions in HNC.

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Complications from Radiotherapy

Gaßner

2020

Complications in Cranio-Maxillofacial and Oral Surgery

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A domestic porcine model for studying the effects of radiation on head and neck cancers

Cited by 6 publications

References 41 publications

Evaluation of an ex vivo porcine model to investigate the effect of low abrasive airpolishing

Evaluation of an ex vivo porcine model to investigate the effect of low abrasive airpolishing

Non-murine models to investigate tumor-immune interactions in head and neck cancer

Complications from Radiotherapy

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