A DNA-RFLP TYPING SYSTEM THAT POSITIVELY IDENTIFIES SEROLOGICALLY WELL-DEFINED AND ILL-DEFINED HLA-DR AND DQ ALLELES, INCLUDING DRw10

Bidwell, J. L.; Bidwell, Elizabeth A.; Savage, David A.; Middleton, D.; Klouda, P. T.; Bradley, Benjamin A.

doi:10.1097/00007890-198803000-00027

Cited by 226 publications

(118 citation statements)

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“…The study of Greggio et al (36) from Italy on the role of HLA on maternal-infant transmission in infants of undefined ethnicity was performed with the RFLP method, which indirectly identifies certain DR alleles (41)(42)(43)(44). These workers reported a DR polymorphism, DRB1-13a4, associated with the DRB1 *1301 allele, to be significantly increased among seroreverters.…”

Section: Resultsmentioning

confidence: 99%

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

Winchester

Chen

Rose

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

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Transmission of human immunodeficiency virus 1 (HIV-1) from an infected women to her offspring during gestation and delivery was found to be influenced by the infant's major histocompatibility complex class II DRBI alleles. Forty-six HIV-infected infants and 63 seroreverting infants, born with passively acquired anti-HIV antibodies but not becoming detectably infected, were typed by an automated nucleotide-sequence-based technique that uses low-resolution PCR to select either the simpler Taq or the more demanding T7 sequencing chemistry. One or more DR13 alleles, including DRBJ*1301, 1302, and 1303, were found in 31.7% of seroreverting infants and 15.2% of those becoming HIV-infected [OR (odds ratio) = 2.6 (95% confidence interval 1.0-6.8); P = 0.048J. This association was influenced by ethnicity, being seen more strongly among the 80 Black and Hispanic children [OR = 4.3 (1.2-16.4); P = 0.023], with the most pronounced effect among Black infants where 7 of 24 seroreverters inherited these alleles with none among 12 HIV-infected infants (Haldane OR = 12.3; P = 0.037). The previously recognized association of DR13 alleles with some situations of long-term nonprogression of HIV suggests that similar mechanisms may regulate both the occurrence of infection and disease progression after infection. Upon examining for residual associations, only the DR2 allele DRBJ*1501 was associated with seroreversion in Caucasoid infants (OR = 24; P = 0.004). Among Caucasoids the DRBJ*03011 allele was positively associated with the occurrence of HIV infection (P = 0.03).

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Section: Resultsmentioning

confidence: 99%

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

Winchester

Chen

Rose

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

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“…The difference in HLA-DRB alleles between various populations can be explained partly by variation in the technique used, small sample size, and linkage disequilibrium. There are many molecular techniques used for typing HLA genes, including PCR-restriction fragment length polymorphism (Bidwell et al, 1988), PCR-SSP (Olerup and Zetterquist, 1992), PCR-single strand conformation polymorphism (Ainsworth et al, 1991;Young and Darke, 1993), PCR-sequence specific oligonucleotide probes (Dalva and Beksac, 2007), and sequencing-based typing (Hoppe and Salama, 2007). In this study, we used the PCR-SSP technique to type HLA alleles.…”

Section: Discussionmentioning

confidence: 99%

Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients

Shi¹,

Hu²,

Yang³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Human leukocyte antigen (HLA) plays a central role in the regulation of the immune response. HLA class II molecules are essential for T cell-mediated adaptive immunity and present peptide antigens to CD4 + T cells. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-DRB alleles and the sequences of the HLA-DRB promoter region in 97 unrelated patients with pulmonary tuberculosis and in 62 unrelated normal controls of the Han nationality from North China, using PCR with sequence-specific primers and PCR direct sequencing. We found that the frequency of HLA-DRB1*15 was significantly higher in the pulmonary tuberculosis group than in the healthy control group. The P value was 0.001, and the odds ratio was 3.793. The pulmonary tuberculosis group had the same HLA-DRB1 promoter region sequences as the control group. We concluded that the HLA-DRB1*15 allele is associated with pulmonary tuberculosis in the Han nationality from North China. The HLA-DRB1 promoter region sequences had no association with the development of pulmonary tuberculosis.

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“…The complement-mediated microlymphocytotoxicity technique has been used as the standard for serologic typing of HLA I and HLA II antigens for many years (Terasaki and McClelland, 1964). Recently, some molecular typing techniques have been developed and used, including PCR and single-strand conformation polymorphism (Ainsworth et al, 1991;Young et al, 1993), PCR-restriction fragment length polymorphism (Bidwell et al, 1988), PCR and sequence-specific oligonucleotide probes (Dalva and Beksac, 2007), PCR-SSP (Olerup and Zetterquist, 1992), and SBT (Hoppe and Salama, 2007). Serologic typing can only yield results of 2 significant figures and 4 molecular typing techniques.…”

Section: Discussionmentioning

confidence: 99%

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

Yang¹,

Wang²,

Shi³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. The primary function of the human leukocyte antigen (HLA) system is to regulate the immune response. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients with lung carcinoma and in 438 unrelated normal controls of Han nationality from North China, using sequencebased typing and PCR with sequence-specific primers. We found that the frequencies of HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, DRB1*0402, and DRB1*1201 were higher in the lung carcinoma group than in the normal control group. The P values were 0.035, 0.040, 0.001, 0.017, 0.014, 0.004, and 0.019, respectively, and the odds ratio values were 1. 052, 3.513, 4.047, 3.054, 4.237, 19.397, and 2.128, respectively. The frequency of HLA-DRB1*1302 was lower in the lung carcinoma group than in the normal control group (P = 0.046, odds ratio = 0.168). We concluded that patients with lung

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A DNA-RFLP TYPING SYSTEM THAT POSITIVELY IDENTIFIES SEROLOGICALLY WELL-DEFINED AND ILL-DEFINED HLA-DR AND DQ ALLELES, INCLUDING DRw10

Cited by 226 publications

References 0 publications

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method.

Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

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