We propose a novel approach to design an integral sliding mode control (ISMC) for a nonlinear system in regular form. The control method is capable to compensate a class of matched and, in particular, unmatched uncertainties with respect to some given output. Conditions for stability and decoupling are presented. For the case of linear nominal dynamics these conditions take a very simple form. A direct comparison to conventional design methods for ISMC is given and the concepts are illustrated using a simulation example.