A Distributed Wireless Network of Implantable Sub-mm Cortical Microstimulators for Brain-Computer Interfaces

Laiwalla, Farah; Lee, Ah-Hyoung; Mok, Ethan; Leung, Vincent; Shellhammer, Stephen J.; Song, Yoon‐Kyu; Larson, L.E.; Nurmikko, A. V.

doi:10.1109/embc.2019.8857217

Cited by 28 publications

(17 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An RF backscatter modulation circuit on the chip produced a binary phase-shift keying (BPSK)-encoded signal, which was recovered by an external RF receiver. The laser-written 10-bit address and an interleaved header sequence were extracted from the backscattering signal after demodulation [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Scalable and Low Stress Post-CMOS Processing Technique for Implantable Microsensors

et al. 2020

Self Cite

View full text Add to dashboard Cite

Implantable active electronic microchips are being developed as multinode in-body sensors and actuators. There is a need to develop high throughput microfabrication techniques applicable to complementary metal–oxide–semiconductor (CMOS)-based silicon electronics in order to process bare dies from a foundry to physiologically compatible implant ensembles. Post-processing of a miniature CMOS chip by usual methods is challenging as the typically sub-mm size small dies are hard to handle and not readily compatible with the standard microfabrication, e.g., photolithography. Here, we present a soft material-based, low chemical and mechanical stress, scalable microchip post-CMOS processing method that enables photolithography and electron-beam deposition on hundreds of micrometers scale dies. The technique builds on the use of a polydimethylsiloxane (PDMS) carrier substrate, in which the CMOS chips were embedded and precisely aligned, thereby enabling batch post-processing without complication from additional micromachining or chip treatments. We have demonstrated our technique with 650 μm × 650 μm and 280 μm × 280 μm chips, designed for electrophysiological neural recording and microstimulation implants by monolithic integration of patterned gold and PEDOT:PSS electrodes on the chips and assessed their electrical properties. The functionality of the post-processed chips was verified in saline, and ex vivo experiments using wireless power and data link, to demonstrate the recording and stimulation performance of the microscale electrode interfaces.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Scale bar: 100 μm. ( b ) Validation of addressing from RF backscattered data for the 10-bit address and an interleaved header sequence (010101) [ 35 ]. Default code is 10b’0; the laser-written address sets a distinctive identity (10111 = 23 in this case).…”

Section: Figurementioning

confidence: 99%

A Scalable and Low Stress Post-CMOS Processing Technique for Implantable Microsensors

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Considering their relatively high viscosity, people can release potential voids by carefully degassing the MED-6215 silicone and applying the silicone before curing it at a normal pressure, which could otherwise lead to liquid water condensing or even encapsulation failure. Besides, Laiwalla’s team [ 51 ] considered that a microscale (500 µm) programmable neural stimulator are hermetically encapsulated using liquid-crystal polymer (LCP) thermocompression for chronic implantability. In fact, a fundamental requirement for the successful operation of implantable systems is an adequate and reliable power supply.…”

Section: Bioelectric Signal Monitoringmentioning

confidence: 99%

Recent Progress in Flexible Wearable Sensors for Vital Sign Monitoring

Liu

Bai

et al. 2020

Sensors

View full text Add to dashboard Cite

With the development of flexible electronic materials, as well as the wide development and application of smartphones, the cloud, and wireless systems, flexible wearable sensor technology has a significant and far-reaching impact on the realization of personalized medical care and the reform of the consumer market in the future. However, due to the high requirements for accuracy, reliability, low power consumption, and less data error, the development of these potential areas is full of challenges. In order to solve these problems, this review mainly searches the literature from 2008 to May 2020, based on the PRISMA process. Based on them, this paper reviews the latest research progress of new flexible materials and different types of sensors for monitoring vital signs (including electrophysiological signals, body temperature, and respiratory frequency) in recent years. These materials and sensors can help realize accurate signal detection based on comfortable and sustainable observation, and may likely be applied to future daily clothing.

show abstract

“…The structure is a 3-coils configuration in which the receiver is a 500 × 500 µm 2 PSC, 3.4 µm thick, operating at 8 mm of Tx-Rx distance. The optimal operating frequency was 915 M Hz of the ISM (Industrial, Scientific and Medical) radio bands with a PDL of 235 µW and a PTE of 0.047% [40], [58]. The neurograin device (650 × 650 × 250 µm 3 ) was recently validated with animal experiments for both neural recordings and stimulation [59].…”

Section: B Ipt Links In Neural Applicationsmentioning

confidence: 99%