A distance-controlled nanoparticle array using PEGylated ferritin

He, Chao; Uenuma, Mutsunori; Okamoto, Naoya; Kamitake, Hiroki; Ishikawa, Yasuaki; Yamashita, Ichiro; Uraoka, Yukiharu

doi:10.1088/2053-1591/1/4/045410

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Slow renal clearance and prolonged plasma half-life are additional advantages. Although the clinical utility of PEGylation is well established and many examples of PEGylated protein cages have been reported, ,,,− the production of anti-PEG IgM antibodies on repeated injection of PEGylated nanoparticles and hypersensitivity observed in some patients have encouraged the development of new polymers. − Poly(2-oxazoline)s and polyketals , are some examples.…”

Section: Tailoring Cage Properties Through Engineeringmentioning

confidence: 99%

Protein Cages: From Fundamentals to Advanced Applications

et al. 2022

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Proteins that self-assemble into polyhedral shell-like structures are useful molecular containers both in nature and in the laboratory. Here we review efforts to repurpose diverse protein cages, including viral capsids, ferritins, bacterial microcompartments, and designed capsules, as vaccines, drug delivery vehicles, targeted imaging agents, nanoreactors, templates for controlled materials synthesis, building blocks for higher-order architectures, and more. A deep understanding of the principles underlying the construction, function, and evolution of natural systems has been key to tailoring selective cargo encapsulation and interactions with both biological systems and synthetic materials through protein engineering and directed evolution. The ability to adapt and design increasingly sophisticated capsid structures and functions stands to benefit the fields of catalysis, materials science, and medicine.

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Section: Tailoring Cage Properties Through Engineeringmentioning

confidence: 99%

Protein Cages: From Fundamentals to Advanced Applications

et al. 2022

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“…Various NPs arrangement techniques have been developed on the basis of the thus generated nanoparticles (NPs) that genetically modify the surface of the protein to impart properties, such as single arrangement, 13,14) one-dimensional array, 15) two-dimensional crystal 16,17) and equidistant arrangement. 18) In particular, in this study, one-dimensional array technology using electric field enhanced ferritin (Fer8-K98E), a ferritin with enhanced surface charge, and a Si substrate with a V-groove were used. 15) In this research, our objective was to directly place NPs on devices with nanoscale channel length, as well as to confirm and verify their action.…”

Section: Introductionmentioning

confidence: 99%

One-dimensional array of gold nanoparticles fabricated using biotemplate and its application to fine FET

Ban

Uenuma

Migita

et al. 2018

Jpn. J. Appl. Phys.

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By synthesizing AuS nanoparticles (NPs) with spherical shell protein (ferritin) and using a V-groove, a one-dimensional array of NPs was formed at the bottom of the V-groove. It has been reported that AuS NPs are converted to Au NPs by UV/ozone treatment. Floating gate memory (FGM) was fabricated by applying this one-dimensional array to V-grooved junctionless (JL) FETs, V-grooved nin-like-type FETs, and pip-like-type FETs, which are fine FETs. In JL-FETs, it is considered that conversion occurred because of good charge storage efficiency, and operation in the opposite direction to normal FGM operation was seen. In the nin-like and pip-like types devices, the same operation as in conventional FGM was shown, and the width of the memory window was about the same size as when one electron entered one NP. The one-dimensional arrangement of the metal NPs used in this study is considered to be applicable to various fields of nanotechnology.

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“…Furthermore studies are also being conducted on different arrangements of NPs. Namely, considering a single NP as zero-dimensional, one-dimensional arrays, [1][2][3] two-dimensional arrays, 4,5) and three-dimensional arrays 6,7) of NPs exist. Different arrangements of NPs are expected to have different quantum effects, and consequently, different mesoregion characteristics and hence unique novel properties.…”

Section: Introductionmentioning

confidence: 99%

One-dimensional arrangement of nanoparticles utilizing the V-groove and cage shaped proteins

Ban

Uenuma

Migita

et al. 2017

Jpn. J. Appl. Phys.

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The one-dimensional arrangement of nanoparticles (NPs) was performed using a V-groove and ferritins as spherical shell proteins. The V-groove was synthesized by lithography and anisotropic etching of a Si substrate. Ferritin has an outer diameter of 12 nm and an inner diameter of 6 nm, and various inorganic substances can be formed into the cavity. In this study, iron oxide, cobalt oxide, and indium oxide cores were used. The surface potential of ferritin can be changed by genetic modification. Particularly, by using Fer8-K98E, NPs could be arranged one-dimensionally onto the bottom of the V-groove. In addition, we succeeded in selectively forming a one-dimensional array of one layer, two layers, and three layers by changing the protein concentration. This experiment is expected to be applicable to various one-dimensional devices.

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A distance-controlled nanoparticle array using PEGylated ferritin

Cited by 5 publications

References 36 publications

Protein Cages: From Fundamentals to Advanced Applications

Protein Cages: From Fundamentals to Advanced Applications

One-dimensional array of gold nanoparticles fabricated using biotemplate and its application to fine FET

One-dimensional arrangement of nanoparticles utilizing the V-groove and cage shaped proteins

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