A disposable paper-based sample clean-up slides for the sensitive determination of trace diethylstilbestrol residues in aquatic products

Li, Feng; Sun, Jing; Jia, Hexiang; Zhang, Yiming; Pang, Linjiang; He, Lianjun; Chai, Tuanyao

doi:10.1016/j.microc.2019.104243

Cited by 7 publications

(2 citation statements)

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“…DES is a typical synthetic estrogen, which is prescribed for preventing miscarriages, regulating estrogen secretion and animal growth [ 11 , 12 ]. Although DES have been prohibited for utilization in aquaculture and animal husbandry in many countries [ 13 ], it remains a threat to human health due to its illegal use in livestock production which leads to growing annual emissions [ 14 , 15 ]. The massive use has resulted in the content of DES in aquatic products at a μg/kg level; this accumulation might be a health threat to people and organisms [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although DES have been prohibited for utilization in aquaculture and animal husbandry in many countries [ 13 ], it remains a threat to human health due to its illegal use in livestock production which leads to growing annual emissions [ 14 , 15 ]. The massive use has resulted in the content of DES in aquatic products at a μg/kg level; this accumulation might be a health threat to people and organisms [ 14 ]. Moreover, concentrations of DES as high as 24.9–102 ng·L −1 and 7.2–16.9 μg·L −1 were detected in some Chinese rivers and fisheries, respectively; this phenomenon showed that DES cannot be completely removed by a treatment plant but exists in natural water bodies for a long time [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Transcriptomic Analysis of Diethylstilbestrol in Daphnia Magna: Energy Metabolism and Growth Inhibition

Zhao

Guo

et al. 2023

Toxics

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With the widespread use of diethylstilbestrol (DES), it has become a common contaminant in the aquatic environment. It is toxic to a wide range of aquatic organisms, disrupting the water flea growth and further interfering with several ecosystem services. Nevertheless, the molecular mechanism of DES in water fleas is still unexplicit. In this study, the 21-day chronic test showed that a negative effect of growth and reproduction can be observed with DES exposure. Subsequently applied transcriptomic analysis illustrated the molecular mechanism in mode freshwater invertebrate Daphnia magna (D. magna) exposed to 2, 200, and 1000 μg·L−1 of DES for 9 days. Meanwhile, exposure to DES at 200 and 1000 μg·L−1 significantly restrains the growth (body length) and reproduction (first spawning time) of D. magna. Identified differentially expressed genes (DEGs) are majorly enriched relative to energy metabolism, lipid metabolism, the digestive system, transport and catabolism pathways which were remarkably changed. These repressed and up-regulated pathways, in relation to energy synthesis and metabolism, may be the reasons for the reduced body length and delayed first spawning time. Taken together, this study revealed that DES is a threat to D. magna in the aquatic environment and clarifies the molecular mechanism of the toxicity.

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