A diffusion tensor imaging analysis of gender differences in water diffusivity within human skeletal muscle

Galbán, Craig J.; Maderwald, Stefan; Uffmann, Kai; Ladd, Mark E.

doi:10.1002/nbm.975

Cited by 86 publications

(111 citation statements)

References 44 publications

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“…Galbán et al (7) stated that gender differences play a role in diffusion properties. However, in our study, we could not find this trend, probably due to the small size of our sample (five males and three females).…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging of the human calf muscle: distinct changes in fractional anisotropy and mean diffusion due to passive muscle shortening and stretching

Schwenzer¹,

Steidle²,

Martirosian³

et al. 2009

NMR in Biomedicine

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aThe influence of passive shortening and stretching of the calf muscles on diffusion characteristics was investigated. The diffusion tensor was measured in transverse slices through the lower leg of eight healthy volunteers (29 W 7 years) on a 3 T whole-body MR unit in three different positions of the foot (40-plantarflexion, neutral ankle position (0-), and S10-dorsiflexion in the ankle). Maps of the mean diffusivity, the three eigenvalues of the tensor and fractional anisotropy (FA) were calculated. Results revealed a distinct dependence of the mean diffusivity and FA on the foot position and the related shortening and stretching of the muscle groups. The tibialis anterior muscle showed a significant increase of 19% in FA with increasing dorsiflexion, while the FA of the antagonists significantly decreased ($20%). Regarding the mean diffusivity of the diffusion tensor, the muscle groups showed an opposed response to muscle elongation and shortening. Regarding the eigenvalues of the diffusion tensor, l 2 and l 3 showed significant changes in relation to muscle length. In contrast, no change in l 1 could be found. This work reveals significant changes in diffusional characteristics induced by passive muscle shortening and stretching.

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Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging of the human calf muscle: distinct changes in fractional anisotropy and mean diffusion due to passive muscle shortening and stretching

Schwenzer¹,

Steidle²,

Martirosian³

et al. 2009

NMR in Biomedicine

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“…In the RGB map, five ROIs were selected from the bilateral ORs to measure the mean FA values. Each ROI area was designed for 9 pixels uniformly and placed symmetrically in both ORs as described in previous studies [36][37][38]. Fibers were clustered into bundles using the normalized cut algorithm.…”

Section: Dti Data Processingmentioning

confidence: 99%

Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia

Cui

et al. 2016

Neurosci. Bull.

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Previous studies have indicated regional abnormalities of both gray and white matter in amblyopia. However, alterations of cortical thickness associated with changes in white matter integrity have rarely been reported. In this study, structural magnetic resonance imaging and diffusion tensor imaging (DTI) data were obtained from 15 children with anisometropic amblyopia and 15 age-and gender-matched children with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical thickness. The fractional anisotropy (FA) values in the optic radiations (ORs) of children with anisometropic amblyopia were lower than in controls (P \ 0.05). The cortical thickness in amblyopic children was lower than controls in the following subregions: lingual cortex, lateral occipitotemporal gyrus, cuneus, occipital lobe, inferior parietal lobe, and temporal lobe (P \ 0.05, corrected), but was higher in the calcarine gyrus (P \ 0.05, corrected). Node-by-node correlation analysis of changes in cortical thickness revealed a significant association between a lower FA value in the OR and diminished cortical thickness in the following subregions: medial lingual cortex, lateral occipitotemporal gyrus, lateral, superior, and medial occipital cortex, and lunate cortex. We also found a relationship between changes of cortical thickness and white matter OR integrity in amblyopia. These findings indicate that developmental changes occur simultaneously in the OR and visual cortex in amblyopia, and provide key information on complex damage of brain networks in anisometropic amblyopia. Our results also support the hypothesis that the pathogenesis of anisometropic amblyopia is neurodevelopmental.

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“…Future studies shall demonstrate to what extent our results can be generalized to other muscle groups and test subjects. It has also been reported that DTI parameters vary depending on muscle examined [23 -26], sex and age [27,28]. DTI parameters also vary with passive and active changes in muscle length [29,30].The intra-individual reliability of DTI parameters of skeletal muscle also warrant further examination.…”

mentioning

confidence: 94%

Diffusion Tensor Imaging of Skeletal Muscle - Correlation of Fractional Anisotropy to Muscle Power

Scheel

Prokscha

Roth

et al. 2013

Fortschr Röntgenstr

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Purpose: Recent DTI studies demonstrated the possibility of fiber geometry visualization in skeletal muscle. We tested for an association between muscle power and standard DTI parameters, e.?g. fractional anisotropy. Materials and Methods: Maximal muscle power (Lmax) of the soleus muscle was determined in 11 healthy subjects. Subsequently DTI was performed and standard parameters (fractional anisotropy ? FA, mean diffusivity ? MD, parallel diffusivity ? PD, radial diffusivity ? RD) were extracted in an ROI of the soleus muscle. Results: We found a signficant association of Lmax with FA (neg. correlation: r?=?-0.85, p?=?0.0015) and RD (pos. correlation r?=?0.80, p?=?0.047). There was no signficant association of MD or PD. Conclusion: Maximum muscle power is an indirect measure of fiber type distribution. The correlation between muscle power and DTI parameters can be explained by differences in fiber diameter and differences in the intracellular microstructure of type-1 and type-2 fibers. DTI should be evaluated as a tool for non-invasive quantification of fiber type distribution in skeletal muscle. Key Points: Citation Format:

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A diffusion tensor imaging analysis of gender differences in water diffusivity within human skeletal muscle

Cited by 86 publications

References 44 publications

Diffusion tensor imaging of the human calf muscle: distinct changes in fractional anisotropy and mean diffusion due to passive muscle shortening and stretching

Diffusion tensor imaging of the human calf muscle: distinct changes in fractional anisotropy and mean diffusion due to passive muscle shortening and stretching

Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia

Diffusion Tensor Imaging of Skeletal Muscle - Correlation of Fractional Anisotropy to Muscle Power

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