A Differentially Pumped Dual Linear Quadrupole Ion Trap (DLQIT) Mass Spectrometer: A Mass Spectrometer Capable of MSⁿ Experiments Free From Interfering Reactions

Abstract

A novel differentially pumped dual linear quadrupole ion trap (DLQIT) mass spectrometer was designed and built to facilitate tandem MS experiments free from interfering reactions. The instrument consists of two differentially pumped Thermo Scientific linear quadrupole ion trap (LQIT) systems that have been connected via an ion transfer octupole encased in a machined manifold. Tandem MS experiments can be performed in the front trap and then the resulting product ions can be transferred via axial ejection into the back trap for further, independent tandem MS experiments in a differentially pumped area. This approach allows the examination of consecutive collision-activated dissociation (CAD) and ion-molecule reactions without unwanted side reactions that often occur when CAD and ion-molecule reactions are examined in the same space. Hence, it greatly facilitates investigations of ion structures. In addition, the overall lower pressure of the DLQIT, as compared to commercial LQIT instruments, results in a reduction of unwanted side reactions with atmospheric contaminants, such as water and oxygen, in CAD and ion-molecule experiments.

Substituent Effects on the Reactivity of the 2,4,6‐Tridehydropyridinium Cation, an Aromatic σ,σ,σ‐Triradical

“…The mono‐, bi‐ and triradicals were generated and studied in a dual‐cell FT‐ICR or a dual linear quadrupole ion trap by using methods described previously , , , . The two instruments yielded identical results.…”

Gas-phase reactions of a novel chemical ionization reagent, ClMn2+, with polar and nonpolar analytes in a linear quadrupole ion trap

“…All reactions were examined in either a Thermo Scientific LTQ linear quadrupole ion trap (LQIT) equipped with a pulsed valve sample introduction interface [11] or a dual linear quadrupole ion trap mass spectrometer [9] (DLQIT) equipped with a reagent mixing manifold [12]. The same results were obtained for both instruments.…”

“…The previous studies on the reagent ion ClMn(H 2 O) + were carried out using an obsoleteFourier-transform ion cyclotron resonance mass spectrometer(FT-ICR) [6][7][8]. In the study discussed here, a commercially available LQIT and a custom built dual linear quadrupole ion trap [9] (DLQIT) were used in order to take advantage of the faster duty cycles of the LQIT [10]. A variety of volatile analytes were studied to ensure unbiased ionization for both polar andnon-polar analytes without fragmentation.…”

Mass Selective Ion Transfer and Accumulation in Ion Trap Arrays

“…However, there is no mass selectivity at all for the ion transfer process, and multiple DC voltages were applied to carefully move all ions from trap number one to trap number two. 28 With the …”

“…However, there is no mass selectivity at all for the ion transfer process, and multiple DC voltages were applied to carefully move all ions from trap number one to trap number two. 28 With the axial ion ejection, space charge effects were decreased with a tandem ion trap array design, in which the first ion trap was used as the accumulation trap and the second ion trap was used as the analyzer trap. 27 In this study, methods for mass selective transfer and accumulation were proposed and realized on two sets of ion trap arrays.…”