“…Currently in the field of protein crystal growth there is experimental evidence both supporting and disputing the presence of structured aggregates in crystalline solutions. For lysozyme, evidence supporting the aggregation theory comes from dialysis kinetics (Wilson, Adcock & Pusey, 1993), neutron scattering (Boue, Lefaucheux, Robert & Rosenman, 1993), sedimentation equilibrium (Sophianopoulos & Van Holde, 1961, 1964, nuclear magnetic resonance (Shindo, Cohen & Rupley, 1977), light scattering intensity (Pusey, 1991) and calorimetry (Banerjee, Pogolotti & Rupley, 1975). Some of these studies were carried out prior to 1980 when the conditions used for studying lysozyme aggregation were close to physiological ionic strength and neutral pH.…”