A diagnostic model of idiopathic central precocious puberty based on transrectal pelvic ultrasound and basal gonadotropin levels

Abstract

Objective To establish a diagnostic model of idiopathic central precocious puberty on the basis of transrectal pelvic ultrasound and basal gonadotropin. Methods A total of 669 girls with Tanner breast development stage II were enrolled in this study from January 2015 to December 2018. The participants were divided into the ICPP group and the premature thelarche group. We analyzed various variables, including age at initial diagnosis, basal luteinizing hormone levels, the long diameter of the uterus, the transverse diameter of the uterus, the anterior–posterior diameter of the uterus, the volume of the uterus, maximum ovarian diameter, average ovarian volume, maximum ovarian volume, number of follicles (≥4 mm), maximum follicular diameter, endometrial thickness, and vaginal wall thickness. Results The following diagnostic model was established: Y=−14.123 + 0.630 × age at initial diagnosis + 1.119 × transverse diameter of the uterus + 1.278 × anterior–posterior diameter of the uterus + 0.637 × average ovarian volume + 1.316 × maximum ovarian diameter + 0.146 ×number of follicles ≥4 mm + 2.925 × endometrial thickness + 0.559 × basal luteinizing hormone value. The area under curve was 0.922, sensitivity was 84.9%, and specificity was 86.2%. Conclusion Basal LH levels and transrectal pelvic ultrasound should be applied together to improve the accuracy of diagnosis in ICPP.

Diagnostic Value of Combined Detection of Pelvic Ultrasound and Serum LH, FSH, and E2 Levels in Children with Idiopathic Central Precocious Puberty

“…At present, GnRH excitation experiments are mostly used for diagnosis in clinical practice, with the disadvantages of being time-consuming, invasive, and having poor compliance. As ultrasound technology advances, pelvic ultrasound is widely used in the diagnosis of ICPP patients due to its advantages of simple operation, high safety, and accuracy and is gaining increasingly more attention and recognition [17][18][19][20]. In similarity to the findings of previous studies [19], in the present study, uterine length and diameter, uterine volume, ovarian area, ovarian volume, maximum follicle diameter, and endometrial thickness were greater in the experimental group than in the control group, suggesting that abnormal sexually secreted hormones can lead to early development of the reproductive organs in children with ICPP; pelvic ultrasound can detect the morphological changes of the children's ovaries and uterus, monitor the development of the children, and provide a basis for the diagnosis of ICPP.…”

Diagnostic Accuracy of Female Pelvic Ultrasonography in Differentiating Precocious Puberty From Premature Thelarche: A Systematic Review and Meta-analysis

“…A total of 1,977 subjects were available for analysis ( Table 1 ). Among the selected studies in this review, 3 were retrospective studies ( 10 – 12 ), 8 were prospective studies ( 13 , 21 , 23 – 26 , 28 , 29 ), and 2 were cross-sectional studies ( 22 , 27 ). All patients had been referred to outpatient clinics to evaluate early breast development and any other pubertal progression signs.…”

Effect of Implantation and Fixation of Mirena in the Treatment of Adenomyosis and its Influence on Serum Inflammatory Factors

“…② VAS score of dysmenorrhea: 0 for painless, 1-3 for mild, 4-6 for moderate and 7-9 for severe. ③ Uterine volume: Color ultrasound was used to measure the transverse diameter, thickness and long diameter of the uterus, and the transverse diameter × thickness × long diameter ×0.523= uterine volume (6). ④ Serum inflammatory indicators: IL-8 (interleukin-8) and TNF-A (tumor necrosis factor-A) were detected by ELISA.…”