Diagnostic Value of Combined Detection of Pelvic Ultrasound and Serum LH, FSH, and E2 Levels in Children with Idiopathic Central Precocious Puberty

Abstract

Objective. To study the diagnostic value of combined detection of pelvic ultrasound and serum LH, FSH, and E2 levels in children with idiopathic central precocious puberty (ICPP). Methods. 30 cases of children with ICPP admitted to our hospital from January 2019 to January 2021 were selected as the experimental group, and 30 healthy people during the same period were selected as the control group. Both groups received pelvic ultrasound and serum LH, FSH, and E2 detection; the two groups were compared in terms of serum indicators, combined diagnosis, specificity, and sensitivity. Results. There were statistical differences in height, leptin, bone age, and areola diameter between the two groups ( p < 0.05 ). The length of the uterus, the volume of the uterus, the area of the ovary, the volume of the ovary, and the maximum diameter of the follicle in the experimental group were larger than those in the control group ( p < 0.05 ). The endometrial thickness of the experimental group was significantly greater than that of the control group ( p < 0.05 ). The levels of serum LH, FSH, and E2 in the experimental group were significantly higher than those in the control group ( p < 0.05 ). The area of the combined detection was significantly larger than that of the single detection. The combined detection was superior to the single detection with respect to the area, standard error a, asymptotic Sig. B, and asymptotic 95% confidence interval ( p < 0.05 ). The sensitivity of the combined detection was significantly higher than that of the single detection. Conclusion. The combined detection of pelvic ultrasound and serum LH, FSH, and E2 levels may be a preferred technique for the diagnosis of children with ICPP due to its benefits of high sensitivity and accuracy. It is worthy of clinical promotion and application.

Childhood obesity and central precocious puberty

“…Therefore, the evaluation of LH peaks after GnRH testing is the gold standard in the biochemical diagnosis of CPP. The combined detection of secondary sexual characters, bone age, hormone levels, pelvic ultrasound and cranial MRI could increase the sensitivity and accuracy for CPP diagnosis (4,5).…”

Integrated multicomponent analysis based on ultra‐high‐performance liquid chromatography coupled with quadrupole‐Exactive Orbitrap mass spectrometry and network pharmacology to elucidate the effective constituents and potential mechanism of Zhibai Dihuang pill in treating childhood precocious puberty

“…Network pharmacology analysis revealed that the core active ingredients in ZBDHP, including tetrahydropalmatine, alisol C, 25‐anhydroalisol A 11‐acetate, hispidone, cavidine, alisol E, melianone, neogitogenin, denudatin B, and 16β‐hydroperoxyalisol B, can help mitigate the formation of precocious puberty. A relevant study has shown that the levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and estradiol (E 2 ) in the CPP group were significantly higher than those in the normal control group 42 . FSH stimulates follicle growth, and LH promotes both oocyte maturation and ovulation.…”

A concise review on breast cancer in pregnancy

“…In menstural cycle there are two phase proliferative phase and secreatory phase, day 1-6 bleeding phase after the that FSH nourhies the ovaries to produce egg, it has millions of egg of that healthy fully matured egg is release by the graffian follicle [36]. The LH is more important in the rupture of graffian follicle to release the mature egg into the fallopian tubes at the day 14 [37]. The graffian follicle has progesterone producing hormone which releases the progesterone which makes the endometrium (the tremendous supply of blood along the side of endometrium to implant the fertilized egg ) if the egg gets fertilized it will get implanted into the endometrium and the corpus luteum continues to secrete progesterone until the labour [38].…”