A diagnostic and clinical significance of the intradermal Mantoux test and Diaskintest in young healthy individuals and people with pulmonary tuberculosis

The diagnostic performance of novel skin-based in-vivo tests for tuberculosis infection compared with purified protein derivative tuberculin skin tests and blood-based in vitro interferon-γ release assays: a systematic review and meta-analysis

“…Of the 14 studies evaluating sensitivity of Diaskintest, risk of bias was high in 5 (35.7%) studies where test assessors were not blinded to TB culture results, 22,33,37,38,44 and unclear in at least one of the four risk of bias criteria in 12 (85.7%) studies as information on patient selection or blinding was not presented. 21,22,32,33,35,37,38,40,[43][44][45][46] Of those evaluating Diaskintest concordance, 11/13 (84.6%) had high risk of bias in the reference standard criterion as assessors of reference standard (TST) were not blinded to index test results, 25,[27][28][29][30][31]34,42,44,47,49 whereas for the index test criterion one had high risk of bias as index test assessors were not blinded to reference standard results 44 and the remaining 12 (92.3%) were classed as unclear as this information was not provided. 21,[25][26][27][28][29][30][31]34,42,47,49 Of all Diaskintest studies, patient selection bias was unclear for 23 out of 29 (79.3%) studies as reporting of patient selection was incomplete.…”

“…21,[25][26][27][28][29][30][31]34,42,47,49 Of all Diaskintest studies, patient selection bias was unclear for 23 out of 29 (79.3%) studies as reporting of patient selection was incomplete. [21][22][23][24][25][26][27][28]30,33,[37][38][39][40]42,44,45,[47][48][49] One C-Tb study scored high on a risk of bias criterion because not all participants received the same reference standard (IGRA or TST). 54 Four out of five (80.0%) C-Tb studies and one EC-skintest study had conflict of interest concerns, as studies either did not report disclosures or were directly affiliated with the test manufacturer.…”

“…Pooled estimates of Diaskintest sensitivity in two-way comparisons were 67% and 88% in HIV-uninfected adults for Diaskintest AI and Diaskintest 5mm , respectively. 22,32,36,37,40,[43][44][45][46] Highly variable methods and sub-populations precluded meaningful meta-analysis for most risk groups; sensitivity estimates from individual studies ranged from 40%-71% in HIV-infected adults 33,38 and from 92% to 100% in uninfected children, 21,32,36 (Supplement Table S7-S9).…”

Test with recombinant tuberculosis allergen (Diaskintest®) in the diagnosis of pulmonary tuberculosis in pulmonological practice

“…Высокая восприимчивость больных ВИЧ к МБТ связана со снижением количества CD4 + -клеток, играющих ключевую роль в формировании противотуберкулезного иммунитета. Именно снижением числа CD4 + -клеток и объясняется низкая эффективность иммунологических тестов [19][20][21][22][23]. Несмотря на противоречивость данных и учитывая высокие риски развития туберкулеза у пациентов с ВИЧ-инфекцией, применение теста в целях улучшения дифференциальной диагностики ТЛ и пневмонии на этапе проведения диагностического минимума в условиях общей лечебной сети является перспективным в пульмонологической практике.…”