A Diabetes Insipidus-Like Condition Produced by Small Doses of Desoxycorticosterone Acetate in Dogs

Influence of the Adrenal Cortex on Body Water Distribution and Renal Function1

“…per minute. This circumstance may be a demonstration of the "diabetes insipidus-like syndrome" reported by others (53)(54)(55)(56).…”

Response of Aged Persons to Administration of Salt and Desoxycorticosterone Acetate

“…Although the most striking effect of desoxycorticosterone acetate (DCA) is the retention of sodium and the excretion of potassium, under certaiu conditions it may act to retain both sodium and water (1, 2) (3, lit. reviewed) (4)(5)(6)(7)(8), and under other conditions to further the excretion of water (3, 9) even to the point of the production of a diabetes-insipidus-like picture (3, [11][12][13][14][15][16][17][18]. Soffer and his associates (19) made these phenomena the basis of a test for Cushing's syndrome, believing that in that condition the normal sodium-retaining effect of desoxycorticosterone acetate was lost.…”