A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia

Oyelere, Sunday Faith; Ajayi, Oluwatobi Hezekiah; Ayoade, Titilayo Eunice; Pereira, George Bueno Santana; Owoyemi, Bolaji Charles Dayo; Ilesanmi, Ajibola Olaoluwa; Akinyemi, O.

doi:10.1016/j.heliyon.2022.e09253

Cited by 20 publications

(8 citation statements)

References 116 publications

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“…MC suppresses mitogen-activated protein kinases (MAPKs) and NF-κB in pancreatic cells, promotes glucose and fatty acid catabolism, stimulates fatty acid absorption, induces insulin production, improves insulin resistance, activates activated protein kinases (AMPK) and inhibits fructose-1,6-bisphosphate and glucose-6-phosphatase. 46 The antidiabetic activity of LC has been attributed to corosolic acid which increases insulin secretion and stimulate glucose uptake in cells. Moreover, ellagitannins including lagerstroemin, flosin B and reginin A were reported to be present in LC and were shown to promote glucose uptake in adipose cells.…”

Section: Discussionmentioning

confidence: 99%

Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus

2023

Acta Med Philipp

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Background and Objectives Type 2 diabetes mellitus (T2DM) is a global health concern affecting more than 400 million people worldwide. Diabetic neuropathy, nephropathy, retinopathy, and cardiovascular complications lead to debilitating effects to patients. To prevent these, the treatment goal is to lower the blood sugar levels and maintain at a normal range which is achieved through conventional treatments like insulin and oral hypoglycemic agents. However, the high cost of these medications implicates patient treatment outcomes. Hence, alternatives are sought for including the use of herbal medicines. Momordica charantia (MC) and Lagerstroemia speciosa (LS) are common herbal medicines used to manage T2DM. In the Philippines, these herbal preparations are validated for their glucose lowering effects and are commonly found in combination in food supplements. The study aims to screen the possible mechanisms of compounds present in these herbal medicines which can offer possible explanations for their synergistic effects and rationalization of their combination in preparations. Methods Network pharmacology was employed to determine pivotal proteins that are targeted by MC and LS compounds. Molecular docking was then done to evaluate the favorability of the binding of these compounds toward their target proteins. Results Our results showed that TNF, HSP90AA1, MAPK3, ALDH2, GCK, AKR1B1, TTR and RBP4 are the possible pivotal targets of MC and LS compounds in T2DM. Conclusion Terpenoids from MC and decanoic acid from LS are the compounds which showed favorable binding towards pivotal protein targets in T2DM. By binding towards the different key proteins in T2DM, they may exhibit their synergistic effects. However, the results of this study are bound to the limitations of computational methods and experimental validation are needed to verify our findings.

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Section: Discussionmentioning

confidence: 99%

Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus

2023

Acta Med Philipp

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“…The bioactive phytochemicals present in Momordica charantia L. include flavonoids, alkaloids and polyphenols in addition to vitamins and minerals which all contribute to its remarkable versatility in treating a wide range of ailments. The potential of Momordica charantia L. to modulate blood glucose has received greater attention from researchers studying natural foods or compounds that are useful in the treatment of diabetes mellitus and have extensively been reviewed (Lucas et al, 2010;Joseph and Jini, 2013;Peter et al, 2019;Liu et al, 2021;Oyelere et al, 2022;Çiçek, 2022). Various parts of the plant have been shown to possess hypoglycemic properties in many animal models and cell-based assays, while a limited number of human clinical trials have been conducted.…”

Section: Momordica Charantia Lmentioning

confidence: 99%

Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review

2022

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Use of medicinal plants and herbs in the treatment and management of diseases, including diabetes mellitus and its complications remains an integral part of African tradition. In Zimbabwe, nearly one million people are living with diabetes mellitus. The prevalence of diabetes mellitus in Zimbabwe is increasing every year due to lifestyle changes, and has accelerated the use of traditional medicines for its treatment and management in urban areas. In addition, the high cost of modern medicine has led many people in rural parts of Zimbabwe to rely on herbal plant medicine for the treatment of diabetes mellitus and its complications. This review highlights a number of studies carried out to evaluate the antidiabetic properties of indigenous plants found in Zimbabwe with the goal of treating diabetes mellitus. Further, we discuss the mechanism of action of various plant extracts in the treatment and management of diabetes mellitus. Together, this review article can open pathways leading to discovery of new plant derived medicines and regularization of use of crude plant remedies to treat diabetes mellitus by the Zimbabwean government and others across Africa.

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“…Momordica charantia L., a member of the Cucurbitaceae family, is an annual climbing plant widely recognized by names such as bitter gourd, bitter melon, or karela. M. charantia is widely grown and consumed in Asia, Africa, and the Americas, across tropical, subtropical, and temperate regions [ 12 , 13 ]. M. charantia has traditionally been utilized to treat diabetes in China, India, Brazil, and Peru [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Momordica charantia L. supplementation on glycemic control and lipid profile in type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Zhang,

Zhao,

Song

et al. 2024

Heliyon

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A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia

Cited by 20 publications

References 116 publications

Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus

Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus

Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review

Effects of Momordica charantia L. supplementation on glycemic control and lipid profile in type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

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