A detailed review on biosynthesis of platinum nanoparticles (PtNPs), their potential antimicrobial and biomedical applications

Jan, Hasnain; Gul, Roby; Andleeb, Anisa; Ullah, Sana; Shah, Muzamil; Khanum, Mehnaz; Ullah, Imran; Hano, Christophe; Abbasi, Bilal Haider

doi:10.1016/j.jscs.2021.101297

Cited by 61 publications

(24 citation statements)

References 169 publications

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“…Accordingly, PtNPs-10 should release more Pt 2+ than PtNPs-40 during a given time interval, and thus affecting the amino acid profile at a different extent. In addition, the higher induction of ROS production upon PtNPs-10 treatment, supports this variation in amino acid profiles ( 72 ).…”

Section: Discussionmentioning

confidence: 80%

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

Mitrevska

Cernei²,

Michalkova³

et al. 2022

Front. Oncol.

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Cisplatin (cis-diamminedichloroplatinum II; CDDP) is a widely used cytostatic agent; however, it tends to promote kidney and liver disease, which are a major signs of drug-induced toxicity. Platinum compounds are often presented as alternative therapeutics and subsequently easily dispersed in the environment as contaminants. Due to the major roles of the liver and kidneys in removing toxic materials from the human body, we performed a comparative study of the amino acid profiles in chicken liver and kidneys before and after the application of CDDP and platinum nanoparticles (PtNPs-10 and PtNPs-40). The treatment of the liver with the selected drugs affected different amino acids; however, Leu and Arg were decreased after all treatments. The treatment of the kidneys with CDDP mostly affected Val; PtNPs-10 decreased Val, Ile and Thr; and PtNPs-40 affected only Pro. In addition, we tested the same drugs on two healthy cell lines, HaCaT and HEK-293, and ultimately explored the amino acid profiles in relation to the tricarboxylic acid cycle (TCA) and methionine cycle, which revealed that in both cell lines, there was a general increase in amino acid concentrations associated with changes in the concentrations of the metabolites of these cycles.

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Section: Discussionmentioning

confidence: 80%

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

Mitrevska

Cernei²,

Michalkova³

et al. 2022

Front. Oncol.

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“…Laser ablation of solid metal has problems with aggregation and inadequate degradation, therefore in previous studies many researchers have shown generation of PtNPs by PLAL (pulsed laser ablation in liquid) ( Waag et al, 2021 ; Fedorova et al, 2020 ; N Madlum et al, 2021 ). The milling process involves gradually decreasing the particle size and mixing them into new phases ( Jan et al, 2021 ; Mathew et al, 2021 ).…”

Section: Ptnps Preparation Methodsmentioning

confidence: 99%

“…Chemical techniques have the following advantages: low cost, good surface chemistry flexibility, simple functionalization, high yields, good control of size, thermal stability, decreased dissipation. However the disadvantages are: low purity, use of toxic chemical reagents and organic solvents that may be harmful to humans and the environment ( Quinson and Jensen, 2020 ; Jan et al, 2021 ; Mathiesen et al, 2021 ).…”

Section: Ptnps Preparation Methodsmentioning

confidence: 99%

Platinum Nanoparticles in Biomedicine: Preparation, Anti-Cancer Activity, and Drug Delivery Vehicles

et al. 2022

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Cancer is the main cause of morbidity and mortality worldwide, excluding infectious disease. Because of their lack of specificity in chemotherapy agents are used for cancer treatment, these agents have severe systemic side effects, and gradually lose their therapeutic effects because most cancers become multidrug resistant. Platinum nanoparticles (PtNPs) are relatively new agents that are being tested in cancer therapy. This review covers the various methods for the preparation and physicochemical characterization of PtNPs. PtNPs have been shown to possess some intrinsic anticancer activity, probably due to their antioxidant action, which slows tumor growth. Targeting ligands can be attached to functionalized metal PtNPs to improve their tumor targeting ability. PtNPs-based therapeutic systems can enable the controlled release of drugs, to improve the efficiency and reduce the side effects of cancer therapy. Pt-based materials play a key role in clinical research. Thus, the diagnostic and medical industries are exploring the possibility of using PtNPs as a next-generation anticancer therapeutic agent. Although, biologically prepared nanomaterials exhibit high efficacy with low concentrations, several factors still need to be considered for clinical use of PtNPs such as the source of raw materials, stability, solubility, the method of production, biodistribution, accumulation, controlled release, cell-specific targeting, and toxicological issues to human beings. The development of PtNPs as an anticancer agent is one of the most valuable approaches for cancer treatment. The future of PtNPs in biomedical applications holds great promise, especially in the area of disease diagnosis, early detection, cellular and deep tissue imaging, drug/gene delivery, as well as multifunctional therapeutics.

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“…Advantageous properties have also been reported for platinum nanoparticles (Pt NPs), resulting in increasing interest for applications in biotechnology, nanomedicine, and pharmacology fields. Specifically, Pt NPs exhibit potent antimicrobial, antioxidant, and anticancer activities; SPR; and photothermal properties, which are all highly valuable characteristics for designing performant nanotherapeutics, drug-delivery systems, and bioimaging agents [122][123][124].…”

Section: Other Metal-based Nanomaterialsmentioning

confidence: 99%

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

et al. 2022

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Cancer continues to represent a global health concern, imposing an ongoing need to research for better treatment alternatives. In this context, nanomedicine seems to be the solution to existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered the advantageous properties of various nanoscale metals, this review aims to present metal-based nanoparticles that are most frequently employed for cancer applications. This paper follows the description of relevant nanoparticles made of metals, metal derivatives, hybrids, and alloys, further discussing in more detail their potential applications in cancer management, ranging from the delivery of chemotherapeutics, vaccines, and genes to ablative hyperthermia therapies and theranostic platforms.

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A detailed review on biosynthesis of platinum nanoparticles (PtNPs), their potential antimicrobial and biomedical applications

Cited by 61 publications

References 169 publications

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

Platinum Nanoparticles in Biomedicine: Preparation, Anti-Cancer Activity, and Drug Delivery Vehicles

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

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