A detailed analysis of the auditory evoked response wave form in children during REM and stage 2 sleep

Tanguay, Peter E.; Lee, John C.M; Ornitz, Edward M.

doi:10.1016/0013-4694(73)90235-6

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Similar findings have been reported in other studies (Pang and Taylor, 2000 ; Ponton et al, 2000 ). In the present study, the finding that N2m latency did not change as a function of age in children 6 months and older is consistent with previous studies (Onishi and Davis, 1969 ; Tanguay et al, 1973 ; Kushnerenko et al, 2002 ; Choudhury and Benasich, 2011 ), including observations from other studies showing that the adult N100/M100 is not robustly observed until early adolescence (Ponton et al, 2000 , 2002 ; Edgar et al, 2014 ).…”

Section: Discussionsupporting

confidence: 94%

The maturation of auditory responses in infants and young children: a cross-sectional study from 6 to 59 months

et al. 2015

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Background: An understanding of the maturation of auditory cortex responses in typically developing infants and toddlers is needed to later identify auditory processing abnormalities in infants at risk for neurodevelopmental disorders. The availability of infant and young child magnetoencephalography (MEG) systems may now provide near optimal assessment of left and right hemisphere auditory neuromagnetic responses in young populations. To assess the performance of a novel whole-head infant MEG system, a cross-sectional study examined the maturation of left and right auditory cortex responses in children 6- to 59-months of age.Methods: Blocks of 1000 Hz (1st and 3rd blocks) and 500 Hz tones (2nd block) were presented while MEG data were recorded using an infant/young child biomagnetometer (Artemis 123). Data were obtained from 29 children (11 males; 6- to 59-months). Latency measures were obtained for the first positive-to-negative evoked response waveform complex in each hemisphere. Latency and age associations as well as frequency and hemisphere latency differences were examined. For the 1000 Hz tone, measures of reliability were computed.Results: For the first response—a response with a “P2m” topography—latencies decreased as a function of age. For the second response—a response with a “N2m” topography—no N2m latency and age relationships were observed. A main effect of tone frequency showed earlier P2m responses for 1st 1000 Hz (150 ms) and 2nd 1000 Hz (148 ms) vs. 500 Hz tones (162 ms). A significant main effect of hemisphere showed earlier N2m responses for 2nd 1000 Hz (226 ms) vs. 1st 1000 Hz (241 ms) vs. 500 Hz tones (265 ms). P2m and N2m interclass correlation coefficient latency findings were as follows: left P2m (0.72, p < 0.001), right P2m (0.84, p < 0.001), left N2m (0.77, p < 0.001), and right N2m (0.77,p < 0.01).Conclusions: Findings of strong age and latency associations, sensitivity to tone frequency, and good test-retest reliability support the viability of longitudinal infant MEG studies that include younger as well as older participants as well as studies examining auditory processing abnormalities in infants at risk for neurodevelopmental disorders.

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Section: Discussionsupporting

confidence: 94%

The maturation of auditory responses in infants and young children: a cross-sectional study from 6 to 59 months

et al. 2015

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“…For example, the first negative auditory component identified in infants is often labeled the N2 (EEG) or N2m (MEG), with the literature suggesting that the N2m component does not develop into the adult M100 auditory response. For example, Edgar et al (2015b) showed that N2m latency did not change as a function of age in children 6 months and older, a finding consistent with several previous studies (Kushnerenko et al, 2002; Choudhury and Benasich, 2011; Onishi and Davis, 1969; Tanguay et al, 1973), and consistent with the observations that the adult N100/M100 is not robustly observed until early adolescence (Edgar et al, 2014a; Ponton et al, 2000, 2002). The above provides an example of an auditory response that studies so far suggest is not easily tracked across the human lifespan.…”

Section: Discussion and Future Directionssupporting

confidence: 77%

Magnetoencephalography and the infant brain

et al. 2019

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Magnetoencephalography (MEG) is a non-invasive neuroimaging technique that provides whole-head measures of neural activity with millisecond temporal resolution. Over the last three decades, MEG has been used for assessing brain activity, most commonly in adults. MEG has been used less often to examine neural function during early development, in large part due to the fact that infant whole-head MEG systems have only recently been developed. In this review, an overview of infant MEG studies is provided, focusing on the period from birth to three years. The advantages of MEG for measuring neural activity in infants are highlighted (See Box 1), including the ability to assess activity in brain (source) space rather than sensor space, thus allowing direct assessment of neural generator activity. Recent advances in MEG hardware and source analysis are also discussed. As the review indicates, efforts in this area demonstrate that MEG is a promising technology for studying the infant brain. As a noninvasive technology, with emerging hardware providing the necessary sensitivity, an expected deliverable is the capability for longitudinal infant MEG studies evaluating the developmental trajectory (maturation) of neural activity. It is expected that departures from neuro-typical trajectories will offer early detection and prognosis insights in infants and toddlers at-risk for neurodevelopmental disorders, thus paving the way for early targeted interventions.

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The recovery cycle of the averaged auditory evoked response during sleep in normal children

Ornitz

Tanguay

Forsythe

et al. 1974

Electroencephalography and Clinical Neurophysiology

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A detailed analysis of the auditory evoked response wave form in children during REM and stage 2 sleep

Cited by 8 publications

References 16 publications

The maturation of auditory responses in infants and young children: a cross-sectional study from 6 to 59 months

The maturation of auditory responses in infants and young children: a cross-sectional study from 6 to 59 months

Magnetoencephalography and the infant brain

The recovery cycle of the averaged auditory evoked response during sleep in normal children

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