A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy

Rossetti, Fábia Cristina; Lopes, Luciana B.; Carollo, Aline Regina Hellmann; Thomazini, José Antônio; Tedesco, Antônio Cláudio; Bentley, Maria Vitória Lopes Badra

doi:10.1016/j.jconrel.2011.06.034

Cited by 69 publications

(50 citation statements)

References 43 publications

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“…PDT can be defined as the systemical, local or topical administration of a nontoxic drug or dye known as photosensitizer (PS), which acquires the desired activity only when it is excited by light of an appropriate wavelength. The excitation of PS results in the production of sufficient reactive oxygen species (ROS) to produce a cytotoxic effect [5,6].…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic characterization and aggregation of azine compounds in different media

Urrutia¹,

Ortiz²

2013

Chemical Physics

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In this study, we have reported for the first time a complete experimental investigation on the compound Neutral Red and the new monobrominated derivative in different media as a function of the concentration. These compounds belong to the quinone-imine class of dyes and have good potential to be applied as photosensitizers in Photodynamic Therapy.Although the aggregation of Neutral Red has been reported by several authors, this has not been thoroughly evaluated due to spectral changes occurring depending on the solvent and concentration of dye.

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Section: Introductionmentioning

confidence: 99%

Spectroscopic characterization and aggregation of azine compounds in different media

Urrutia¹,

Ortiz²

2013

Chemical Physics

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“…Traditionally, transdermal formulation was designed to achieve systemic therapeutics by transfering drug into blood circulation through skin layers. Physical and chemical methods have been developed to overcome the remarkable barrier properties of the outermost layer of skin, the stratum corneum (SC) and enhance the transdermal delivery of drugs (Doh et al, 2003;Qiu et al, 2008;Rossetti et al, 2011). However, transdermal formulation attracted much attention on topical skin targeting application in recent decades.…”

Section: Introductionmentioning

confidence: 99%

Topical skin targeting effect of penetration modifiers on hairless mouse skin, pig abdominal skin and pig ear skin

Guo

Liu

et al. 2013

Drug Delivery

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Objective: This study was to investigate the topical skin targeting effects and mechanism of combination penetration modifiers of 1,2-hexanediol (or 1,2-heptanediol) and 1,4-cyclohexanediol on transdermal absorption of metronidazole (MTZ) in different skin models. Methods: Six formulations were applied to pig abdominal skin and pig ear skin models, respectively, and the results were compared with the previous data on hairless mouse skin worked out by our laboratory. Four parameters (flux, T lag , Q 24 and targeting ratio) were used to evaluate permeability and targeting effect in skin. Results: The combined penetration modifiers played a general role on decreasing permeability without reducing skin retention. The most significant skin permeability decrement to MTZ was pig abdominal skin (permeability decrement was $20% for hairless mouse skin, 60% for pig abdominal skin and 40% for pig ear skin, respectively) while the strongest skin targeting effect appeared in hairless mouse skin (targeting ratios were 1.79 for hairless mouse skin, 1.24 for pig abdominal skin and 1.05 for pig ear skin, respectively) under the role of penetration modifiers. Conclusions: Thickness of stratum corneum (SC) was the major factor impact on skin targeting effect. Selection criteria of skin models also have been discussed in this study.

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“…They are characterized by far-red wavelength absorption (> 670 nm), long triplet lifetime (∼1 ms), high quantum yields of singlet oxygens (> 0.2), and low dark toxicity [28][29][30]. The main advantage in the use of phthalocyanine as photosensitizer is the fact that this family of dyes could act by the two classical PDI mechanisms of radical production (type I) or singlet oxygen (type II) [31].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

et al. 2012

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Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc) LASERS IN MEDICAL SCIENCE, LONDON, v. 27, n. 6, pp. 1205-1212, NOV, 2012 ). The biofilm cells were scraped off the well wall, homogenized, and seeded onto Sabouraud dextrose agar plates that were then incubated at 37°C for 48 h. Efficient PDI of biofilms was verified by counting colony-forming units (CFU/ml), and the data were submitted to analysis of variance and the Tukey test (p<0.05).All biofilms studied were susceptible to PDI with statistically significant differences. The strains of Candida genus were more resistant to PDI than emerging pathogens T. mucoides and K. ohmeri. A mean reduction of 0.45 log was achieved for Candida spp. biofilms, and a reduction of 0.85 and 0.84, were achieved for biofilms formed by T. mucoides and K. ohmeri, respectively. Therefore, PDI by treatment with nanostructured formulations cationic zinc 2,9,16,23-tetrakis (phenylthio)-29H, 31H-phthalocyanine (ZnPc) and a laser reduced the number of cells in the biofilms formed by strains of C. albicans and non-Candida albicans as well the emerging pathogens T. mucoides and K. ohmeri.

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A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy

Cited by 69 publications

References 43 publications

Spectroscopic characterization and aggregation of azine compounds in different media

Spectroscopic characterization and aggregation of azine compounds in different media

Topical skin targeting effect of penetration modifiers on hairless mouse skin, pig abdominal skin and pig ear skin

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

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