A delicate redox balance between iron and heme oxygenase-1 as an essential biological feature of endometriosis

Imanaka, Shogo; Yamada, Yoshiaki; Kawahara, Naoki; Kobayashi, Hiroshi

doi:10.1016/j.arcmed.2021.03.006

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…In this study, bilirubin was downregulated in FF in the EM group, and there was a significant positive correlation between bilirubin and the high‐quality embryo rate. This is contrary to the increase in bilirubin in cyst fluid of the EM group found by previous researchers 49 . However, some studies have found that there is no difference in blood bilirubin in patients with endometriosis, 50 which may be due to the difference in the samples.…”

Section: Discussioncontrasting

confidence: 72%

“…This is contrary to the increase in bilirubin in cyst fluid of the EM group found by previous researchers. 49 However, some studies have found that there is no difference in blood bilirubin in patients with endometriosis, 50 which may be due to the difference in the samples. As an antioxidant, the downregulation of bilirubin may indicate an increase in oxidative stress in FF, indicating that EM may enhance the level of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Nontargeted metabolomics analysis of follicular fluid in patients with endometriosis provides a new direction for the study of oocyte quality

Wei

Zhang

et al. 2023

MedComm

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Endometriosis is a common, estrogen‐dependent chronic gynecological disease that endangers the reproductive system and systemic metabolism of patients. We aimed to investigate the differences in metabolic profiles in the follicular fluid between infertile patients with endometriosis and controls. A total of 25 infertile patients with endometriosis and 25 infertile controls who were similar in age, BMI, fertilization method and ovulation induction treatment were recruited in this study. Metabolomics analysis of follicular fluid was performed by two methods of high‐performance liquid chromatography tandem mass spectrometry. There were 36 upregulated and 17 downregulated metabolites in the follicular fluid of patients in the endometriosis group. KEGG pathway analysis revealed that these metabolites were enriched in phenylalanine, tyrosine and tryptophan biosynthesis, aminoacyl‐tRNA biosynthesis, phenylalanine metabolism and pyrimidine metabolism pathways. A biomarker panel consisting of 20 metabolites was constructed by random forest, with an accuracy of 0.946 and an AUC of 0.988. This study characterizes differences in follicular fluid metabolites and associated pathway profiles in infertile patients with endometriosis. These findings can provide a better comprehensive understanding of the disease and a new direction for the study of oocyte quality, as well as potential metabolic markers for the prognosis of endometriosis.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Nontargeted metabolomics analysis of follicular fluid in patients with endometriosis provides a new direction for the study of oocyte quality

Wei

Zhang

et al. 2023

MedComm

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“…[79,80] Examples include the resynthesis of haptoglobin in endometriotic lesions and a significant increase in the expression of the heme oxygenase 1 gene, both of which have important antioxidant and immunomodulatory roles, and are primarily involved in stimulus responses, the immune system, metabolism, localization and cellular processes. [81,82] The resistance of EMT to ferroptosis is demonstrated by the expression of multiple genes to regulate lipid peroxidation and amino acid metabolism to influence ferroptosis in ectopic lesions. Experimental evidence suggests that long chain non-coding ribonucleic acid (RNA), which are RNA molecules more than 200 nucleotides in length and do not have protein coding capacity, play an important regulatory role in the pathophysiologic mechanisms of EMT.…”

Section: Mechanisms Of Ferroptosis Resistance In Emtmentioning

confidence: 99%

Section: Ferroptosis In Emtmentioning

confidence: 99%

Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature

Ni,

2024

Medicine

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Background: Endometriosis (EMT) a common gynecological condition in women, an inflammatory disease characterized by the presence of endometrial tissue on organs and tissues in the pelvis, and is mainly associated with chronic pelvic pain and infertility. As the etiology has not been fully elucidated, current treatment is limited to surgery, hormones and painkillers, with more side effects and difficulty in achieving long-term relief. Oxidative stress manifests itself as an overproduction of reactive oxygen species, which has an integral impact in the pathology of female reproductive disorders. In this review, we evaluate the mechanisms of iron overload-induced oxidative stress and ferroptosis in EMT and their pathophysiological implications. Methods: Because the etiology has not been fully elucidated, current treatments are limited to surgery, hormones, and painkillers, which have many side effects and are difficult to achieve long-term relief. Results: We interpreted that antioxidants as well as ferroptosis inducers show promising results in the treatment of EMT, but their application in this population needs to be further investigated. Conclusion: In combination with the interpretation of previous studies, it was shown that iron overload is present in the peritoneal fluid, endometriotic lesions, peritoneum and macrophages in the abdominal cavity. However, the programmed cellular ferroptosis associated with iron overload is resisted by endometriotic foci, which is critical to the pathophysiology of EMT with local iron overload and inflammation.

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“…Since this disease is characterized by high iron content in the local environment due to retrograde menstruation, there is a high probability of oxidative stress [ 112 ]. Large amounts of this trace element have been detected not only in ectopic lesions [ 105 , 113 , 114 ] but also in peritoneal fluid [ 115 ], follicular fluid [ 91 , 116 , 117 ], and blood [ 118 ] collected from patients with endometriosis. Additionally, suggestions indicating the involvement of Fe in the malignant transformation of OMA [ 119 ], dysmenorrhea [ 120 ], or the formation of adhesions [ 121 ] further emphasize the important role of Fe in the pathogenesis of endometriosis.…”

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Abramiuk,

Mertowska,

Frankowska

et al. 2024

Nutrients

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Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since the treatment options for this disease are still limited, and the cure rate is unsatisfactory, the search for ways to treat symptoms and modify the course of the disease is of key importance in improving the quality of life of patients with endometriosis. So far, the literature has shown that nutrition can influence endometriosis through hormonal modification and altering the inflammatory or oxidative response. Since the importance of nutrition in this disease is still a subject of scientific research, we aimed to summarize the current knowledge on the role of dietary modifications in endometriosis. Our review showed that nutrients with anti-inflammatory and antioxidant properties, including most vitamins and several trace elements, may influence the pathogenesis of endometriosis and can be considered as the nutrients preventing the development of endometriosis. However, despite the many discoveries described in this review, further interdisciplinary research on this topic seems to be extremely important, as in the future, it may result in the development of personalized therapies supporting the treatment of endometriosis.

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A delicate redox balance between iron and heme oxygenase-1 as an essential biological feature of endometriosis

Cited by 9 publications

References 26 publications

Nontargeted metabolomics analysis of follicular fluid in patients with endometriosis provides a new direction for the study of oocyte quality

Nontargeted metabolomics analysis of follicular fluid in patients with endometriosis provides a new direction for the study of oocyte quality

Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

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