A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat

Su, Zhenqi; Bernardo, Amy; Tian, Bin; Chen, Hui; Wang, Shan; Ma, Hongxiang; Cai, Sheng; Liu, Dongtao; Zhang, Dadong; Li, Tao; Trick, Harold N.; Amand, Paul St.; Yu, Jianming; Zhang, Zengyan; Bai, Guihua

doi:10.1038/s41588-019-0425-8

Cited by 268 publications

(230 citation statements)

References 49 publications

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“…Qfhs.nau-6B (Fhb2), Qfhi.nau-4B (Fhb4), and Qfhi.nau-5A (Fhb5) were fine mapped in the 2.2 cM, 0.14 cM, and 0.09 cM interval [16]. Fhb1 has been cloned recently [18][19][20]. In current study, four loci (28 MTAs) were identified on chromosomes 1B, 4A, 5D and 7A in two seasons.…”

Section: Fhb Resistance Loci Identified By Gwasmentioning

confidence: 59%

“…Twenty-eight MTAs located on chromosomes 1B (1), 4A (7), 5D (19) and 7A (1) were consistently identified in both seasons and could be considered as stable QTL (Table 1), SNP GENE-0293_154 located on 1B explained 6.91-7.18% of phenotypic variances (R 2 ). Seven and 19 SNPs located on 4AL and 5DL chromosomes explained phenotypic variances (R 2 ) ranging from 9.36-11.63% and 8.11-14.18%, respectively.…”

Section: Marker-trait Associationsmentioning

confidence: 99%

“…Fhb1 was reported as a pore-forming toxin-like gene (PFT) QTL [18]. However, recent studies revealed an histidine-rich calcium-binding protein (His) was responsible for the Fhb1 resistance [19,20]. A comprehensive discussion on the two studies has been performed, and the nature of Fhb1 resistance remains unclear [21].…”

Section: Introductionmentioning

confidence: 99%

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Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Gao

et al. 2020

BMC Plant Biol

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Background: Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is a major threat to wheat production and food security worldwide. Breeding stably and durably resistant cultivars is the most effective approach for managing and controlling the disease. The success of FHB resistance breeding relies on identification of an effective resistant germplasm. We conducted a genome-wide association study (GWAS) using the highdensity wheat 90 K single nucleotide polymorphism (SNP) assays to better understand the genetic basis of FHB resistance in natural population and identify associated molecular markers.Results: The resistance to FHB fungal spread along the rachis (Type II resistance) was evaluated on 171 wheat cultivars in the 2016-2017 (abbr. as 2017) and 2017-2018 (abbr. as 2018) growing seasons. Using Illumina Infinum iSelect 90 K SNP genotyping data, a genome-wide association study (GWAS) identified 26 loci (88 marker-trait associations), which explained 6.65-14.18% of the phenotypic variances. The associated loci distributed across all chromosomes except 2D, 6A, 6D and 7D, with those on chromosomes 1B, 4A, 5D and 7A being detected in both years. New loci for Type II resistance were found on syntenic genomic regions of chromsome 4AL (QFhb-4AL, 621.85-622.24 Mb) and chromosome 5DL (QFhb-5DL, 546.09-547.27 Mb) which showed high collinearity in gene content and order. SNP markers wsnp_JD_c4438_5568170 and wsnp_CAP11_c209_198467 of 5D, reported previously linked to a soil-borne wheat mosaic virus (SBWMV) resistance gene, were also associated with FHB resistance in this study. Conclusion: The syntenic FHB resistant loci and associated SNP markers identified in this study are valuable for FHB resistance breeding via marker-assisted selection.

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Section: Fhb Resistance Loci Identified By Gwasmentioning

confidence: 59%

Section: Marker-trait Associationsmentioning

confidence: 99%

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Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Gao

et al. 2020

BMC Plant Biol

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“…Rawat et al (2016) that mutation of the histidine-rich calcium-binding protein as the gene responsible for 424 Fhb1 resistance. However, in conflict with the findings of Su et al (2019), their data 425 suggests that this is due to a gain-of-function resulting from an different start codon 426 positioned upstream to the original (Li et al, 2019). Our data on the 3HS-3BL centric 427 fusion line does not suggest that 3BS contains a susceptibility factor, as the line was 428 either wild type-like or more highly susceptible to the spread of FHB.…”

Section: Discussion 294mentioning

confidence: 60%

“…Although the gene(s) underlying Fhb1, the most widely deployed FHB resistance 61 QTL, remains controversial, there is evidence that Fhb1 may be considered a 62 disrupted susceptibility factor (Su et al, 2019;Su et al, 2018). Plant hormones play 63 an important role in responding to disease.…”

Section: Introductionmentioning

confidence: 99%

Type II Fusarium head blight susceptibility factor identified in wheat

Hales

Steed

Giovannelli

et al. 2020

Preprint

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Type II Fusarium head blight susceptibility factor identified in wheat HighlightWe have identified a Type II Fusarium head blight susceptibility factor on the short arm of wheat chromosome 4D and refined its position to a 31.7 Mbp interval. AbstractFusarium head blight (FHB) causes significant grain yield and quality reductions in wheat and barley. Most wheat varieties are incapable of preventing FHB spread through the rachis, but disease is typically limited to individually infected spikelets in barley. We point inoculated wheat lines possessing barley chromosome introgressions to test whether FHB resistance could be observed in a wheat genetic background. The most striking differential was between 4H(4D) substitution and 4H addition lines. The 4H addition line was similarly susceptible to the wheat parent, but the 4H(4D) substitution line was highly resistant, which suggests that there is an FHB susceptibility factor on wheat chromosome 4D. Point inoculation of Chinese Spring 4D ditelosomic lines demonstrated that removing 4DS results in high FHB resistance. We genotyped four Chinese Spring 4DS terminal deletion lines to better characterise the deletions in each line. FHB phenotyping indicated that lines del4DS-2 and del4DS-4, containing smaller deletions, were susceptible and had retained the susceptibility factor. Lines del4DS-3 and del4DS-1 contain larger deletions and were both significantly more resistant, and hence had presumably lost the susceptibility factor. Combining the genotyping and phenotyping results allowed us to refine the susceptibility factor to a 31.7 Mbp interval on 4DS.

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Harnessing Genetic Diversity for Addressing Wheat‐based Time Bound Food Security Projections

Mujeeb‐Kazi¹,

Ali²,

Dundas³

et al. 2022

Bioresource Technology

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A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat

Cited by 268 publications

References 49 publications

Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Genome-wide association mapping revealed syntenic loci QFhb-4AL and QFhb-5DL for Fusarium head blight resistance in common wheat (Triticum aestivum L.)

Type II Fusarium head blight susceptibility factor identified in wheat

Harnessing Genetic Diversity for Addressing Wheat‐based Time Bound Food Security Projections

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