A Defoaming Agent Should Be Used with Pronase Premedication to Improve Visibility in Upper Gastrointestinal Endoscopy

Abstract

Premedication as in group E provided the clearest endoscopic visibility. Without the application of DMPS, pronase alone cannot improve endoscopic visibility. Pronase does not influence H. pylori identification using the CLO test.

A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS

“…Hence the findings of this study are in keeping with those of several previous studies demonstrating improvements in gastric mucosal visibility with a pre-gastroscopy drink containing a mucolytic and a defoaming agent 9 10 14. This is the first study to specifically assess the effect of the combination of simethicone and NAC on the quality of mucosal visibility in a Western population.…”

“…Several studies have demonstrated that drinking a defoaming agent before a procedure improves mucosal visibility 7 8. Results are conflicting among studies that have examined whether the addition of a mucolytic such as N-acetylcysteine (NAC) to a defoaming agent offers any further benefit 9 10 11 12 13.…”

Benefit of pronase in image quality during EUS

“…5,13 Some investigators have reported that premedication with a defoaming agent and pronase improved visibility to a greater degree than did pronase alone during upper GI endoscopy. 14 In addition, others have reported that premedication with a defoaming agent and acetylcysteine, a mucolytic agent, or pronase improved visibility during EUS. 6,15 No special preparation is usually required for EUS of the upper GI tract.…”

Diagnostic value of confocal laser endomicroscopy for gastric superficial cancerous lesions

“…In total, 20 mg scopolamine butylbromide was given by intramuscular injection, and 50 ml of saline solution containing 1 g bicarbonate sodium and 20 000 units α-chymotrypsin was taken orally 15–20 min before endoscopy 9 12…”