Diagnostic value of confocal laser endomicroscopy for gastric superficial cancerous lesions

Abstract

CLE can be used to identify gastric superficial cancer/HGIN lesions with high validity and reliability.

Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

“…Yao [33] reported that finding a white opaque substance on magnified endoscope with narrow band imaging differentiates intraepithelial neoplasia with a sensitivity of 94% and a specificity of 96%. Moreover, confocal laser endomicroscopy is reported to identify gastric superficial cancer/HGIN lesions with high validity and reliability compared to conventional white-light endoscopy and histological analysis for the final diagnosis [34] . Although image-enhanced endoscopy and confocal laser endomicroscopy are promising methods and modalities to improve the pre-therapeutic diagnostic accuracy of intraepithelial neoplasia, it is not yet clear whether they are clinically useful because of expert bias.…”

Molecular in vivo imaging of gastric cancer in a human-murine xenograft model: targeting epidermal growth factor receptor

“…27,28,[31][32][33] Recent studies further evaluated the benefit of conventional CLE to both diagnose and guide endoscopic resection of gastric neoplasia by visualizing histomorphological alterations. 28,34,35 In contrast, we aimed at establishing protocols for molecular staining with both diagnostic and therapeutic anti- bodies in our xenograft model. This could translate into 2 different clinical situations: first, the early detection of gastric cancer in screening patients and, second, the molecular characterization of a given lesion in a (suspected) cancer patient.…”

Intravital Three-Dimensional Dynamic Pathology of Experimental Colitis in Living Mice Using Two-Photon Laser Scanning Microscopy

“…11,12 However, confocal laser endomicroscopy has the limitation of imaging at a depth of approximately 250 μm from the mucosal surface and the increased phototoxicity for gastrointestinal mucosa. Thus, the development of a multiphoton (or two-photon) endomicroscopy could, therefore, provide deeper penetration imaging and less phototoxicity, allowing a high-resolution in vivo real-time histopathology of gastrointestinal diseases in clinical practice.…”